Results 31 to 40 of about 3,227 (260)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Agriculture, 2023 The discrete element method (DEM) is an effective tool for obtaining qualitative and quantitative information on particle motion, which aids in the design and optimization of agricultural equipment structures.
Xiaolong Lei +8 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Effect of the Width of an Aluminum Plate on a Bouncing Steel Ball [PDF]
International Scholastic Journal of Science, 2013 The effect of the distance between clamping supports of an aluminum alloy plate on the coefficient of restitution of a bouncing steel ball was investigated. The plate was supported on two wooden blocks with a meter stick secured on either side.
Christine Hathaway, Hanh Nguyen
doaj +1 more source
The Development of Educational Aids for Restitution Coefficient Experiment Using Microcontroller
JPPPF: Jurnal Penelitian & Pengembangan Pendidikan Fisika, 2022 This study aims to produce a product in the form of high school physics teaching aids for collision materials. The aids developed consist of Arduino as the central controller, photodiode sensor, and infrared sensor as ball motion detector mounted on the ...
Widyaningrum Indrasari +2 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Shuiwen dizhi gongcheng dizhiAccurate prediction of rockfall trajectory is foundation for the prevention and control of rock avalanche geological disasters in mountainous areas. A key factor influencing trajectory accuracy is the appropriate selection of the collision restitution ...
Dongling NONG +5 more
doaj +1 more source
The Coefficient of Restitution Does Not Exceed Unity [PDF]
Journal of Statistical Physics, 2006 12 pages, including 2 figure. This is the final version, which will appear in J.
openaire +2 more sources