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Lighting up bioluminescence with coelenterazine: strategies and applications
Photochemical & Photobiological Sciences, 2016Bioluminescence-based techniques, such as bioluminescence imaging, BRET and dual-luciferase reporter assay systems, have been widely used to examine a myriad of biological processes. Coelenterazine (CTZ), a luciferin or light-producing compound found in bioluminescent organisms, has sparked great curiosity and interest in searching for analogues with ...
Tianyu, Jiang, Lupei, Du, Minyong, Li
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Photochemistry and Photobiology, 2020
AbstractCalcium‐regulated photoproteins are found in at least five phyla of organisms. The light emitted by those photoproteins can be tuned by mutating the photoprotein and/or by modifying the substrate coelenterazine (CTZ). Thirty years ago, Shimomura observed that the luminescence activity of aequorin was dramatically reduced when the substrate CTZ ...
Bo‐Wen Ding +3 more
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AbstractCalcium‐regulated photoproteins are found in at least five phyla of organisms. The light emitted by those photoproteins can be tuned by mutating the photoprotein and/or by modifying the substrate coelenterazine (CTZ). Thirty years ago, Shimomura observed that the luminescence activity of aequorin was dramatically reduced when the substrate CTZ ...
Bo‐Wen Ding +3 more
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Unexpected Coelenterazine Degradation Products of Beroe abyssicola Photoprotein Photoinactivation.
Organic Letters, 2021Ca2+-regulated photoproteins of ctenophores lose bioluminescence activity when exposed to visible light. Little is known about the chemical nature of chromophore photoinactivation.
L. Burakova +9 more
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Glowing jellyfish, luminescence and a molecule called coelenterazine
Trends in Biotechnology, 1999Luminescence has assumed an important role in analytical biochemistry and molecular biology as an extremely sensitive method for determining the concentration of specific ions and molecules. The luminescent system of the jellyfish Aequorea victoria consists of the photoprotein aequorin, which contains the molecule coelenterazine as a prosthetic group ...
K, Jones, F, Hibbert, M, Keenan
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Mix-and-read bioluminescent copper detection platform using a caged coelenterazine analogue.
In Analysis, 2021Serum copper levels are biomarkers for copper-related diseases. Quantification of levels of free copper (not bound to proteins) in serum is important for diagnosing Wilson's disease, in which the free copper concentration is elevated.
Ryo Nishihara, R. Kurita
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Widespread occurrence of coelenterazine in marine bioluminescence
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1980Abstract 1. 1. Coelenterazine is a compound having a key role in the light-emitting process of bioluminescent coelenterates. Present evidence concerning the occurrence of coelenterazine and luciferase in other types of marine organisms establishes that coelenterazine is required for bioluminescence of various, distantly related, types of ...
Osamu Shimomura +3 more
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Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence.
Bioconjugate chemistry, 2020A synthetic luciferin comprising an imidazopyrazinone core, named HuLumino1, was designed to generate specific bioluminescence with human serum albumin (HSA) in real serum samples.
Ryo Nishihara +3 more
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Journal of Chemical Theory and Computation, 2012
A systematic investigation of the structural and spectroscopic properties of coelenteramide has been performed at the TD-CAM-B3LYP/6-31+G(d,p) level of theory, including various fluorescence and chemiluminescence states. The influence of geometric conformations, solvent polarity, protonation state, and the covalent character of the O-H bond of the ...
Chen, S.-F. +5 more
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A systematic investigation of the structural and spectroscopic properties of coelenteramide has been performed at the TD-CAM-B3LYP/6-31+G(d,p) level of theory, including various fluorescence and chemiluminescence states. The influence of geometric conformations, solvent polarity, protonation state, and the covalent character of the O-H bond of the ...
Chen, S.-F. +5 more
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Bioconjugate chemistry
Paper-based analytical devices (PADs) are promising platforms to achieve Point-of-Care Testing (POCT) due to their low cost, ease of operation, disposability, and simplicity of assaying.
Sung-Bae Kim +7 more
semanticscholar +1 more source
Paper-based analytical devices (PADs) are promising platforms to achieve Point-of-Care Testing (POCT) due to their low cost, ease of operation, disposability, and simplicity of assaying.
Sung-Bae Kim +7 more
semanticscholar +1 more source
Efficient synthesis and antioxidant activity of coelenterazine analogues
Tetrahedron Letters, 2014Abstract A convenient and highly convergent method for the synthesis of new imidazo[1,2- a ]pyridine-based coelenterazine analogues is reported. The imidazo[1,2- a ]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals.
Rudi Hendra +2 more
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