Results 1 to 10 of about 24,711 (245)

Prevalence of oral manifestations in coeliac disease and associated factors [PDF]

BMC Gastroenterology
Background Various oral manifestations are associated with coeliac disease in children, whereas data on adults are scarce. Moreover, possible individual factors predisposing to these manifestations remain unresolved.
Jani Manninen, Saana Paavola, Kalle Kurppa, Heini Huhtala, Teea Salmi, Katri Kaukinen, Camilla Pasternack   +6 more
doaj   +2 more sources

Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning

Frontiers in Immunology, 2021
Chronic inflammation of the small intestine in celiac disease is driven by activation of CD4+ T cells that recognize gluten peptides presented by disease-associated HLA-DQ molecules.
Shuo-Wang Qiao, Shuo-Wang Qiao, Shiva Dahal-Koirala, Shiva Dahal-Koirala, Linn M. Eggesbø, Knut E. A. Lundin, Knut E. A. Lundin, Ludvig M. Sollid, Ludvig M. Sollid   +8 more
doaj   +1 more source

Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T‐Cell‐Directed Therapies

Advanced Science, 2021
Gluten‐specific CD4+ T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T‐cell‐directed therapy can change with time and upon activation in CeD and other autoimmune ...
Asbjørn Christophersen, Stephanie Zühlke, Eivind G. Lund, Omri Snir, Shiva Dahal‐Koirala, Louise Fremgaard Risnes, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +8 more
doaj   +1 more source

Phenotype‐Based Isolation of Antigen‐Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease

Advanced Science, 2022
The pathogenic immune response in celiac disease (CeD) is orchestrated by phenotypically distinct CD4+ T cells that recognize gluten epitopes in the context of disease‐associated HLA‐DQ allotypes.
Asbjørn Christophersen, Shiva Dahal‐Koirala, Markéta Chlubnová, Jørgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid   +5 more
doaj   +1 more source

Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

Frontiers in Immunology, 2021
Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular V-genes and conserved CDR3 ...
Shiva Dahal-Koirala, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Louise Fremgaard Risnes, Ralf Stefan Neumann, Asbjørn Christophersen, Asbjørn Christophersen, Knut E. A. Lundin, Knut E. A. Lundin, Knut E. A. Lundin, Geir Kjetil Sandve, Shuo-Wang Qiao, Shuo-Wang Qiao, Ludvig M. Sollid, Ludvig M. Sollid   +14 more
doaj   +1 more source

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3

Nature Communications, 2023
Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications.
Julie Elisabeth Heggelund, Saykat Das, Jorunn Stamnaes, Rasmus Iversen, Ludvig M. Sollid   +4 more
doaj   +1 more source

Association between coeliac disease and cardiovascular disease: prospective analysis of UK Biobank data

BMJ Medicine, 2023
Objectives To investigate whether people with coeliac disease are at increased risk of cardiovascular disease, including ischaemic heart disease, myocardial infarction, and stroke.Design Prospective analysis of a large cohort study.Setting UK Biobank ...
Elizabeth Soilleux, Megan Conroy, Naomi Allen, Thomas Littlejohns, Ben Lacey   +4 more
doaj   +1 more source

In Well‐Treated Celiac Patients Low‐Level Mucosal Inflammation Predicts Response to 14‐day Gluten Challenge

Advanced Science, 2021
In celiac disease (CeD), gluten activates adaptive immune cells that cause damage to the small intestinal mucosa. Histological evaluation of intestinal biopsies allows for grading of disease severity.
Jorunn Stamnaes, Daniel Stray, Maria Stensland, Vikas K. Sarna, Tuula A. Nyman, Knut E. A. Lundin, Ludvig M. Sollid   +6 more
doaj   +1 more source

Single-cell transcriptomics combined with proteomics of intrathecal IgG reveal transcriptional heterogeneity of oligoclonal IgG-secreting cells in multiple sclerosis

Frontiers in Cellular Neuroscience, 2023
The phenotypes of B lineage cells that produce oligoclonal IgG in multiple sclerosis have not been unequivocally determined. Here, we utilized single-cell RNA-seq data of intrathecal B lineage cells in combination with mass spectrometry of intrathecally ...
Justyna Polak, Justyna Polak, Justyna Polak, Johanna H. Wagnerberger, Silje Bøen Torsetnes, Ida Lindeman, Ida Lindeman, Rune A. Aa. Høglund, Rune A. Aa. Høglund, Frode Vartdal, Frode Vartdal, Ludvig M. Sollid, Ludvig M. Sollid, Ludvig M. Sollid, Andreas Lossius, Andreas Lossius, Andreas Lossius   +16 more
doaj   +1 more source

Risk of vascular diseases in patients with dermatitis herpetiformis and coeliac disease: a long-term cohort study

Annals of Medicine, 2023
Introduction Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. Increased cardiovascular morbidity has been reported in coeliac disease, but in DH only little is known about this.
Noora Nilsson, Joonas Leivo, Pekka Collin, Inka Koskinen, Katri Kaukinen, Heini Huhtala, Johanna Palmio, Timo Reunala, Kaisa Hervonen, Teea Salmi, Camilla Pasternack   +10 more
doaj   +1 more source