Results 171 to 180 of about 166,204 (247)

Longitudinal Cognitive Function in Progressive Supranuclear Palsy—A Review of the Evidence for Progression

Movement Disorders Clinical Practice, EarlyView.
Abstract Progressive supranuclear palsy is a rare and rapidly progressive neurodegenerative syndrome. Clinical manifestations are heterogeneous and include Parkinsonism, postural instability, oculomotor dysfunction and cognitive impairment, with 80% of patients progressing to dementia within 3 years. Cognitive impairment is consistently associated with
Timothy P. Siejka, Kelly L. Bertram, Helmut Butzkueven, David Darby, Amy Brodtmann   +4 more
wiley   +1 more source

Probing the Human 4-Oxo-l-proline Reductase-Catalyzed Reaction by Deuterium Kinetic and Equilibrium Isotope Effects. [PDF]

Biochemistry
Pečaver E, Kabu M, Zickuhr GM, Harrison DJ, da Silva RG.   +4 more
europepmc   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Silver Nanoparticle-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Low-Molecular-Weight Compounds in a Narcissus Bulb. [PDF]

Molecules
Arendowska I, Arendowski A.
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Strained Partnership: Biocompatibility and Transcriptomic Responses of Hydrogenotrophic Methanogens to Methyl Diethanolamine in Bio-integrated Carbon Capture and Utilization. [PDF]

Environ Sci Technol
Wijesooriya MM, Eskildsen M, Nielsen JL, Kofoed MVW.   +3 more
europepmc   +1 more source

The construction of a genome‐wide transposon library of Glaesserella parasuis and its use to identify genes essential for in vitro and in vivo survival

mLife, EarlyView.
Abstract Glaesserella parasuis is an important porcine pathogen that commonly colonizes the upper respiratory tract of pigs and is the etiological agent of Glässer's disease, causing substantial economic losses in the global swine industry. This study aimed to identify genes essential for both in vitro growth and in vivo pathogenicity of G.
Xiaowei Gong, Yuqian Shi, Liuqing He, Qingpo Cui, Guanzheng Zhao, Shuo Xu, Luyu Ying, Qin Yang, Xiaoxia Qin, Tong Sun, Xiaotong Jiang, Juanjuan Wang, Zhangqi Shen, Mengjiao Fu   +13 more
wiley   +1 more source

FLIM quantification of temperature-dependent enzyme-NADH binding dynamics. [PDF]

Biomed Opt Express
Martinez J, Theodossiou A, Hu L, Walsh AJ.   +3 more
europepmc   +1 more source

Statin Exposure and Survival Outcomes in Amyotrophic Lateral Sclerosis in an Asian Cohort

Muscle &Nerve, EarlyView.
ABSTRACT Introduction Data from Asian cohorts on whether statin therapy affects amyotrophic lateral sclerosis (ALS) progression are limited. We examined whether statin exposure was associated with ALS disease duration or tracheostomy‐free survival in a multiethnic Asian ALS cohort.
Anushika Raheja, Kexin Ang, Bernett Lee, Seyed Ehsan Saffari, Eng King Tan, Crystal Jing Jing Yeo   +5 more
wiley   +1 more source