Results 191 to 200 of about 166,204 (247)

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source

Restoring glucose metabolic homeostasis to attenuate ovarian aging: mechanisms and clinical prospects. [PDF]

J Ovarian Res
Zeng G, Chu M, Yang J, Han Y, Zhou Q, Zhang H, Yan Y.   +6 more
europepmc   +1 more source

Gastritis and age‐related macular degeneration: Potential roles of metabolomic dysregulation and photoreceptor alterations

VIEW, EarlyView.
Abstract Age‐related macular degeneration (AMD) is a degenerative retinal disorder and a leading cause of global visual impairment, yet effective treatments remain limited. While gastritis is a prevalent clinical condition among older populations and has been associated with adverse effects on the central nervous system, its potential association with ...
Jingxin Zhou, Jiawei Wang, Yingcheng He, Jing Cao, Jiayu Duan, Juan Ye   +5 more
wiley   +1 more source

Effects of evolocumab on plasma coenzyme Q10 in patients with heterozygous familial hypercholesterolemia. [PDF]

Atheroscler Plus
Tada H, Takeji Y, Takamura M.
europepmc   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Iron starvation confers azole tolerance in <i>Aspergillus fumigatus</i> hyphae via mitochondrial function modulation. [PDF]

mBio
Cong L, Lin Z, Li Q, Wang W, Zhang S.
europepmc   +1 more source

A horizontally acquired pantothenate gene drives vitellogenin's benefit to whitefly symbiosis persistence

Insect Science, EarlyView.
This diagram illustrates that the horizontally transferred panBC influences the level and localization of vitellogenin (Vg) by facilitating pantothenate production and juvenile hormone (JH) biosynthesis. In turn, Vg shields symbionts by suppressing autophagic degradation in bacteriocytes.
Xiang Sun, Bing‐Qi Liu, Zhan‐Bo Chen, Chu‐Qiao Li, Xing‐Ye Li, Jun‐Bo Luan   +5 more
wiley   +1 more source

Emerging Medications in Facial Nerve Recovery: A Systematic Review and Meta-Analysis. [PDF]

OTO Open
Chan K, Ma C, Sciscent BY, Urso A, Goyal N, Lighthall JG.   +5 more
europepmc   +1 more source