Results 211 to 220 of about 25,277,741 (360)

Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells

open access: yesEnvironmental Toxicology, Volume 38, Issue 1, Page 225-242, January 2023., 2023
Abstract Per‐ and polyfluoroalkyl substances (PFAS), which include perfluorooctanoic acid (PFOA), heptafluorobutyric acid (HFBA), and perfluorotetradecanoic acid (PFTA), are commonly occurring organic pollutants. Exposure to PFAS affects the immune system, thyroid and kidney function, lipid metabolism, and insulin signaling and is also involved in the ...
Qi Qi   +6 more
wiley   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe   +4 more
wiley   +1 more source

Revealing the contribution of GbPR10.5D1 to resistance against Verticillium dahliae and its regulation for structural defense and immune signaling

open access: yesThe Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract As an important family of pathogenesis‐related (PR) proteins, the functional diversification and roles of PR10s in biotic stress have been well documented. However, the molecular basis of PR10s in plant defense responses against pathogens remains to be further understood.
Jin Guo   +6 more
wiley   +1 more source

Advances and Challenges in the Development of Immobilized Enzymes for Batch and Flow Biocatalyzed Processes

open access: yesChemSusChem, EarlyView.
Recent advancements in the preparation of immobilized enzymes have improved both batch and continuous flow biocatalytic processes, essential for cost‐effective, sustainable production in the fine chemicals and pharmaceutical industries. This review examines advancements in carrier‐free methods, entrapment strategies, and support‐based approaches ...
Stefania Patti   +5 more
wiley   +1 more source

Characterization of pig skeletal muscle transcriptomes in response to low temperature

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 181-190, January 2023., 2023
Low temperature changes the gene expression pattern and biological pathway in pig skeletal muscle. Under low temperature, biological pathways of lipid, amino acid, and carbohydrate metabolism; signal transduction; endocrine, immune, and nervous system; cardiovascular disease; infectious diseases caused by bacteria or viruses; and neurodegenerative ...
DongJie Zhang   +4 more
wiley   +1 more source

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