Results 351 to 360 of about 25,277,741 (360)

Clinical and genetic associations of autoantibodies to 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme a reductase in patients with immune‐mediated myositis and necrotizing myopathy

Muscle and Nerve, 2015
Introduction: Inhibition of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR) with statins may trigger idiopathic inflammatory myositis (IIM) or immune‐mediated necrotizing myopathy (IMNM). Anti‐HMGCR antibodies have been detected in patients with
V. Limaye, C. Bundell, P. Hollingsworth, A. Rojana-udomsart, F. Mastaglia, P. Blumbergs, S. Lester   +6 more
semanticscholar   +1 more source

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

Archives of Neurology, 2000
CONTEXT Increasing evidence suggests that cholesterol plays a role in the pathophysiology of Alzheimer disease (AD). For instance, an elevated serum cholesterol level has been shown to be a risk factor for AD.
B. Wolozin, Wendy Kellman, Paul Ruosseau, G. Celesia, G. Siegel   +4 more
semanticscholar   +1 more source

Coenzyme A biosynthetic machinery in mammalian cells.

Biochemical Society Transactions, 2014
CoA (coenzyme A) is an essential cofactor in all living organisms. CoA and its thioester derivatives [acetyl-CoA, malonyl-CoA, HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) etc.] participate in diverse anabolic and catabolic pathways, allosteric regulatory ...
David Lopez Martinez, Y. Tsuchiya, I. Gout   +2 more
semanticscholar   +1 more source

Coenzyme A and its derivatives: renaissance of a textbook classic.

Biochemical Society Transactions, 2014
In 1945, Fritz Lipmann discovered a heat-stable cofactor required for many enzyme-catalysed acetylation reactions. He later determined the structure for this acetylation coenzyme, or coenzyme A (CoA), an achievement for which he was awarded the Nobel ...
F. Theodoulou, O. Sibon, S. Jackowski, I. Gout   +3 more
semanticscholar   +1 more source

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.

Biochemical Society Transactions, 2014
The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl carrier in all organisms, have long been regarded as excellent targets for the development of new antimicrobial drugs.
Wessel J A Moolman, M. de Villiers, E. Strauss   +2 more
semanticscholar   +1 more source

Coenzyme Q10

Pharmacy Today, 2019
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies.
Anne L. Hume
semanticscholar   +1 more source

Coenzyme A: to make it or uptake it?

Nature reviews. Molecular cell biology, 2016
O. Sibon, E. Strauss
semanticscholar   +1 more source

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

Nature Structural &Molecular Biology, 2015
Hui Wang, M. Klein, Hua Zou, W. Lane, G. Snell, I. Levin, Ke Li, Biching Sang   +7 more
semanticscholar   +1 more source

Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.

Nature Chemical Biology, 2015
Balaji Srinivasan, M. Baratashvili, Marianne van der Zwaag, B. Kanon, C. Colombelli, Roald A. Lambrechts, O. Schaap, E. Nollen, A. Podgoršek, G. Kosec, H. Petković, S. Hayflick, V. Tiranti, D. Reijngoud, Nicola A. Grzeschik, O. Sibon   +15 more
semanticscholar   +1 more source

LC-MS/MS-based analysis of coenzyme A and short-chain acyl-coenzyme A thioesters

Analytical and Bioanalytical Chemistry, 2015
S. Neubauer, D. Chu, Hans Marx, M. Sauer, S. Hann, G. Koellensperger   +5 more
semanticscholar   +1 more source