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The Production of Coenzyme Q10 in Microorganisms
2012Coenzyme Q10 has emerged as a valuable molecule for pharmaceutical and cosmetic applications. Therefore, research into producing and optimizing coenzyme Q10 via microbial fermentation is ongoing. There are two major paths being explored for maximizing production of this molecule to commercially advantageous levels. The first entails using microbes that
Dominic Pinel +2 more
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Coenzyme Q10 in cardiovascular disease
Mitochondrion, 2007In this review we summarise the current state of knowledge of the therapeutic efficacy and mechanisms of action of CoQ(10) in cardiovascular disease. Our conclusions are: 1. There is promising evidence of a beneficial effect of CoQ(10) when given alone or in addition to standard therapies in hypertension and in heart failure, but less extensive ...
Silvana Marasco +10 more
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Coenzyme Q10 in Male Infertility
2016This chapter deals with the role of coenzyme Q10 in male infertility in the light of the increasing evidence of oxidative damage and antioxidant defence in sperm cells and seminal plasma. Reactive oxygen species have a key pathogenetic role in male infertility as well as a well-recognized physiological function.
Giancarlo Balercia +3 more
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2016
Human coenzyme Q (CoQ10) or ubiquinone is mainly known for its bioenergetic role as a proton and electron carrier in the inner mitochondrial membrane and is also an endogenous lipophilic antioxidant, ubiquitous in biological membranes. It is also present in plasma lipoproteins, where it plays a well-recognized antioxidant role.
Francesca Brugè +2 more
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Human coenzyme Q (CoQ10) or ubiquinone is mainly known for its bioenergetic role as a proton and electron carrier in the inner mitochondrial membrane and is also an endogenous lipophilic antioxidant, ubiquitous in biological membranes. It is also present in plasma lipoproteins, where it plays a well-recognized antioxidant role.
Francesca Brugè +2 more
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Biochemical and Biophysical Research Communications, 1974
Summary Rats which were unilaterally nephrectomized and treated with deoxycorticosterone acetate and saline developed hypertension, and had an increased heart weight. Treatment of these rats with coenzyme Q10 effected a lower level of hypertension and normalized the heart weight.
C. Gunnar Blomqvist +3 more
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Summary Rats which were unilaterally nephrectomized and treated with deoxycorticosterone acetate and saline developed hypertension, and had an increased heart weight. Treatment of these rats with coenzyme Q10 effected a lower level of hypertension and normalized the heart weight.
C. Gunnar Blomqvist +3 more
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Hospital Pharmacy, 2001
Coenzyme Q10 (CoQ10) is a provitamin manufactured by the body. It functions as a coenzyme for mitochondrial enzymes. It has been shown to be deficient in patients with cardiovascular disease, cancer, Acquired Immune Deficiency Syndrome (AIDS), muscular dystrophy, spontaneous abortion, male infertility, and periodontal disease.
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Coenzyme Q10 (CoQ10) is a provitamin manufactured by the body. It functions as a coenzyme for mitochondrial enzymes. It has been shown to be deficient in patients with cardiovascular disease, cancer, Acquired Immune Deficiency Syndrome (AIDS), muscular dystrophy, spontaneous abortion, male infertility, and periodontal disease.
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Clinical aspects of coenzyme Q10: an update
Current Opinion in Clinical Nutrition & Metabolic Care, 2005Coenzyme Q10 is administered for an ever-widening range of disorders, therefore it is timely to illustrate the latest findings with special emphasis on areas in which this therapeutic approach is completely new. These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10.Cardiovascular ...
Gian Paolo Littarru, Luca Tiano
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2020
Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, thereby reducing production of farnesyl pyrophosphate, an intermediate in the mevalonate pathway. The mevalonate pathway ultimately produces both cholesterol and coenzyme Q10 (CoQ10), a protein important for mitochondrial function.
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Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, thereby reducing production of farnesyl pyrophosphate, an intermediate in the mevalonate pathway. The mevalonate pathway ultimately produces both cholesterol and coenzyme Q10 (CoQ10), a protein important for mitochondrial function.
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Coenzyme Q10 in Neurodegenerative Diseases
Current Medicinal Chemistry, 2003Coenzyme Q(10) (ubiquinone), which serves as the electron acceptor for complexes I and II of the mitochondrial electron transport chain and also acts as an antioxidant, has the potential to be a beneficial agent in neurodegenerative diseases in which there is impaired mitochondrial function and/or excessive oxidative damage.
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Coenzyme Q10 a mitochondrial restorer for various brain disorders
Naunyn-Schmiedeberg's Archives of Pharmacology, 2021Nilima Pradhan, Charan Singh, Arti Singh
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