Results 1 to 10 of about 41,185 (159)

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death. [PDF]

PLoS ONE, 2010
Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP opening but the outcome of PTP regulation by ubiquinone analogs on cell fate has not been studied ...
Flavien Devun, Ludivine Walter, Julie Belliere, Cécile Cottet-Rousselle, Xavier Leverve, Eric Fontaine   +5 more
doaj   +1 more source

An Investigation into the Effects of Ubiquinone on Inflammation, Diabetic Myopathy and Endotheliopathy, and CBC Parameters in Diabetic Rats

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2023
Oxidative stress and inflammation are connected to the development of metabolic disorders, such as diabetes. Diabetic-related oxidative stress is caused by the overproduction of oxidative-free radicals, which have been implicated in the mechanism of ...
Yousif Jameel Jbrael, Badraldin Kareem Hamad   +1 more
doaj   +1 more source

Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

Antioxidants, 2020
The aim of this study is to investigate the glycemic profile, oxidative stress, and antioxidant capacity in athletes after 12 weeks of ubiquinone supplementation. It was a double-blinded, randomized, parallel, placebo-controlled study.
Chien-Chang Ho, Po-Sheng Chang, Hung-Wun Chen, Po-Fu Lee, Yun-Chi Chang, Ching-Yu Tseng, Ping-Ting Lin   +6 more
doaj   +1 more source

UbiJ-SCP2 Ubiquinone synthesis protein

, 2019
UbiJ-SCP2 Ubiquinone synthesis ...
Legrand, P., Fyfe, C. D., Ciccone, L., Pecqueur, L., Lombard, M., Fontecave, M.   +5 more
core   +3 more sources

A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Mitochondria are both the cellular powerhouse and the major source of reactive oxygen species. Coenzyme Q(10) plays a key role in mitochondrial energy production and is recognized as a powerful antioxidant.
Christian Bergamini, Noah Moruzzi, Antonella Sblendido, Giorgio Lenaz, Romana Fato   +4 more
doaj   +1 more source

Coenzyme Q10 Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms

Frontiers in Cardiovascular Medicine, 2022
ObjectiveEffective interventions that might limit myocardial ischemia-reperfusion (I/R) injury are still lacking. Coenzyme Q10 (CoQ10) may exert cardioprotective actions that reduce myocardial I/R injury.
Kamal Awad, Kamal Awad, Ahmed Sayed, Maciej Banach, Maciej Banach, Maciej Banach   +5 more
doaj   +1 more source

RegB Kinase Activity Is Controlled in Part by Monitoring the Ratio of Oxidized to Reduced Ubiquinones in the Ubiquinone Pool

mBio, 2010
RegB is a membrane-spanning sensor kinase responsible for redox regulation of a wide variety of metabolic processes in numerous proteobacterial species. Here we show that full-length RegB purified from Escherichia coli membranes contains bound ubiquinone.
Jiang Wu, Carl E. Bauer
doaj   +1 more source

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

mBio, 2022
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer ...
Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno   +9 more
doaj   +1 more source

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

Pathogens, 2023
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Santosh Kumar, Steven Sega, Jamie K. Lynn-Barbe, Dannika L. Harris, Jordan T. Koehn, Debbie C. Crans, Dean C. Crick   +6 more
doaj   +1 more source

Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy [PDF]

International Journal of Ophthalmology, 2013
AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50).
Orhan Ates, Habip Bilen, Sadullah Keles, H. Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Öndaş, L. Can Pınar, Mustafa Civelekler, Orhan Baykal   +9 more
doaj   +1 more source