Results 11 to 20 of about 63,603 (255)
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Multistationary and Oscillatory Modes of Free Radicals Generation by the Mitochondrial Respiratory Chain Revealed by a Bifurcation Analysis [PDF]
, 2012 The mitochondrial electron transport chain transforms energy satisfying cellular demand and generates reactive oxygen species (ROS) that act as metabolic signals or destructive factors.
Mark F. Schumaker +6 more
core +5 more sources
Structures and proton-pumping strategies of mitochondrial respiratory enzymes [PDF]
, 2001 Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the ...
Chan, Sunney I., Schultz, Brian E.
core +1 more source
BMC Cancer, 2020 Background Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer ...
Man-Yee Chan +6 more
doaj +1 more source
Pathogens, 2023 In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Santosh Kumar +6 more
doaj +1 more source
, 2019 The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production.
Barcelos, Isabella Peixoto de +1 more
core +1 more source
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018 Background Ubiquinone has antioxidant properties and has been linked to cognitive performance in some neuropsychiatric disorders. Its role in specific learning disorder manifestations has not been previously investigated. Therefore, the aim of this study
Ehab Ragaa Abdelraouf +6 more
doaj +1 more source
The Use of Coenzyme Q10 in Cardiovascular Diseases
Antioxidants, 2021 CoQ10 is an endogenous antioxidant produced in all cells that plays an essential role in energy metabolism and antioxidant protection. CoQ10 distribution is not uniform among different organs, and the highest concentration is observed in the heart ...
Yoana Rabanal-Ruiz +2 more
doaj +1 more source
Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress
Регуляторные исследования и экспертиза лекарственных средств, 2019 The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants.
O. A. Goroshko +3 more
doaj +1 more source
Tuning ubiquinone position in biomimetic monolayer membranes [PDF]
, 2017 Artificial lipid bilayers have been extensively studied as models that mimic natural membranes (biomimetic membranes). Several attempts of biomimetic membranes inserting ubiquinone (UQ) have been performed to enlighten which the position of UQ in the ...
Guaus Guerrero, Ester +2 more
core +2 more sources