Results 11 to 20 of about 36,766 (230)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Coenzyme Q10 Reduces Infarct Size in Animal Models of Myocardial Ischemia-Reperfusion Injury: A Meta-Analysis and Summary of Underlying Mechanisms

Frontiers in Cardiovascular Medicine, 2022
ObjectiveEffective interventions that might limit myocardial ischemia-reperfusion (I/R) injury are still lacking. Coenzyme Q10 (CoQ10) may exert cardioprotective actions that reduce myocardial I/R injury.
Kamal Awad, Kamal Awad, Ahmed Sayed, Maciej Banach, Maciej Banach, Maciej Banach   +5 more
doaj   +1 more source

Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018
Background Ubiquinone has antioxidant properties and has been linked to cognitive performance in some neuropsychiatric disorders. Its role in specific learning disorder manifestations has not been previously investigated. Therefore, the aim of this study
Ehab Ragaa Abdelraouf, Ayman Kilany, Adel F. Hashish, Ola Hosny Gebril, Suzette Ibrahim Helal, Haytham Mohamad Hasan, Neveen Hassan Nashaat   +6 more
doaj   +1 more source

Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy [PDF]

International Journal of Ophthalmology, 2013
AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50).
Orhan Ates, Habip Bilen, Sadullah Keles, H. Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Öndaş, L. Can Pınar, Mustafa Civelekler, Orhan Baykal   +9 more
doaj   +1 more source

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

mBio, 2022
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer ...
Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno   +9 more
doaj   +1 more source

The risks of ubiquinone and β-carotene deficiency and metabolic disorders in patients with oral cancer

BMC Cancer, 2020
Background Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer ...
Man-Yee Chan, Bor-Jen Lee, Po-Sheng Chang, Han-Yu Hsiao, Li-Ping Hsu, Chia-Hua Chang, Ping-Ting Lin   +6 more
doaj   +1 more source

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

Pathogens, 2023
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Santosh Kumar, Steven Sega, Jamie K. Lynn-Barbe, Dannika L. Harris, Jordan T. Koehn, Debbie C. Crans, Dean C. Crick   +6 more
doaj   +1 more source

Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress

Регуляторные исследования и экспертиза лекарственных средств, 2019
The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants.
O. A. Goroshko, L. M. Krasnykh, V. G. Kukes, V. I. Zozina   +3 more
doaj   +1 more source

The Use of Coenzyme Q10 in Cardiovascular Diseases

Antioxidants, 2021
CoQ10 is an endogenous antioxidant produced in all cells that plays an essential role in energy metabolism and antioxidant protection. CoQ10 distribution is not uniform among different organs, and the highest concentration is observed in the heart ...
Yoana Rabanal-Ruiz, Emilio Llanos-González, Francisco Javier Alcain   +2 more
doaj   +1 more source

Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone

Journal of Lipid Research, 1968
The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-l-14C and mevalonate-2-14C incorporation studies both in vivo and in vitro confirm the results of
M.R. Lakshmanan, W.E.J. Phillips, R.L. Brien   +2 more
doaj   +1 more source