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How plants synthesize coenzyme Q. [PDF]

open access: yesPlant Commun, 2022
Coenzyme Q (CoQ) is a conserved redox-active lipid that has a wide distribution across the domains of life. CoQ plays a key role in the oxidative electron transfer chain and serves as a crucial antioxidant in cellular membranes.
Xu JJ, Hu M, Yang L, Chen XY.
europepmc   +4 more sources

Biosynthesis, Deficiency, and Supplementation of Coenzyme Q. [PDF]

open access: yesAntioxidants (Basel), 2023
Originally identified as a key component of the mitochondrial respiratory chain, Coenzyme Q (CoQ or CoQ10 for human tissues) has recently been revealed to be essential for many different redox processes, not only in the mitochondria, but elsewhere within
Staiano C   +6 more
europepmc   +2 more sources

Understanding coenzyme Q. [PDF]

open access: yesPhysiol Rev
Coenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and a long isoprenoid side chain. It is thus extremely hydrophobic and resides in membranes. It is best known for its complex function as an electron transporter in the mitochondrial electron transport chain (ETC) but is also required for several other crucial cellular ...
Wang Y, Lilienfeldt N, Hekimi S.
europepmc   +3 more sources

The Ubiquitous and Multifaceted Coenzyme Q. [PDF]

open access: yesAntioxidants (Basel)
Coenzyme Q10 (CoQ10) is composed of a benzoquinone ring and an isoprenoid side chain attached to carbon 3 of the ring [...]
Tiano L, Navas P.
europepmc   +2 more sources

Research Progress of Coenzyme Q in Diabetes Mellitus and Its Common Complications. [PDF]

open access: yesDiabetes Metab Syndr Obes
Jingdong Xia,1,2 Xiudan Li,1,2 Chunying Bai,2 Xuchen Han1 1Affiliated Hospital of Chifeng University, Chifeng, The Inner Mongol Autonomous Region, Chifeng, People’s Republic of China; 2Key Laboratory of Research on Human Genetic Diseases at Universities ...
Xia J, Li X, Bai C, Han X.
europepmc   +2 more sources

Coenzyme Q biochemistry and biosynthesis. [PDF]

open access: yesTrends Biochem Sci, 2023
Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse cellular processes. Although most known for shuttling electrons between mitochondrial electron transport chain (ETC) complexes, the roles for CoQ are far more wide-reaching and ever-expanding.
Guerra RM, Pagliarini DJ.
europepmc   +3 more sources

New Insights on the Uptake and Trafficking of Coenzyme Q. [PDF]

open access: yesAntioxidants (Basel), 2023
Coenzyme Q (CoQ) is an essential lipid with many cellular functions, such as electron transport for cellular respiration, antioxidant protection, redox homeostasis, and ferroptosis suppression.
Guile MD   +3 more
europepmc   +2 more sources

COQ8A-Ataxia as a Manifestation of Primary Coenzyme Q Deficiency. [PDF]

open access: yesMetabolites, 2022
COQ8A-ataxia is a mitochondrial disease in which a defect in coenzyme Q10 synthesis leads to dysfunction of the respiratory chain. The disease is usually present as childhood-onset progressive ataxia with developmental regression and cerebellar atrophy ...
Paprocka J   +3 more
europepmc   +2 more sources

Endogenous coenzyme Q content and exogenous bioavailability in D. melanogaster. [PDF]

open access: yesHeliyon
Development and aging significantly impact the cellular levels of Coenzyme Q (CoQ), which is associated with both pathological and physiological conditions.
Cirilli I   +6 more
europepmc   +2 more sources

The role of Coenzyme Q10 in statin-associated myopathy [PDF]

open access: yesElectronic Physician, 2009
Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors, are cholesterol-lowering drugs which are frequently used in the primary and secondary prevention of coronary artery disease.
Sanjay Kalra   +4 more
doaj   +2 more sources

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