Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency [PDF]
Frontiers in Physiology, 2017 Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid.
Fabien Pierrel
exaly +4 more sources
Research Progress of Coenzyme Q in Diabetes Mellitus and Its Common Complications [PDF]
Diabetes, Metabolic Syndrome and ObesityJingdong Xia,1,2 Xiudan Li,1,2 Chunying Bai,2 Xuchen Han1 1Affiliated Hospital of Chifeng University, Chifeng, The Inner Mongol Autonomous Region, Chifeng, People’s Republic of China; 2Key Laboratory of Research on Human Genetic Diseases at Universities ...
Xia J, Li X, Bai C, Han X
doaj +4 more sources
The Ubiquitous and Multifaceted Coenzyme Q [PDF]
AntioxidantsCoenzyme Q10 (CoQ10) is composed of a benzoquinone ring and an isoprenoid side chain attached to carbon 3 of the ring [...]
Luca Tiano, Plácido Navas
doaj +5 more sources
Biosynthesis, Deficiency, and Supplementation of Coenzyme Q [PDF]
Antioxidants, 2023 Originally identified as a key component of the mitochondrial respiratory chain, Coenzyme Q (CoQ or CoQ10 for human tissues) has recently been revealed to be essential for many different redox processes, not only in the mitochondria, but elsewhere within
Carmine Staiano +6 more
doaj +2 more sources
How plants synthesize coenzyme Q [PDF]
Plant Communications, 2022 Coenzyme Q (CoQ) is a conserved redox-active lipid that has a wide distribution across the domains of life. CoQ plays a key role in the oxidative electron transfer chain and serves as a crucial antioxidant in cellular membranes.
Jing-Jing Xu +3 more
doaj +2 more sources
New Insights on the Uptake and Trafficking of Coenzyme Q [PDF]
Antioxidants, 2023 Coenzyme Q (CoQ) is an essential lipid with many cellular functions, such as electron transport for cellular respiration, antioxidant protection, redox homeostasis, and ferroptosis suppression.
Michael D. Guile +3 more
doaj +2 more sources
Statin-Induced Coenzyme Q Deficiency Induces Metabolic Reprogramming in Astrocytes [PDF]
AntioxidantsStatins are commonly used cholesterol-lowering drugs, but their effects on astrocyte oxidative metabolism are poorly understood. To investigate this, rat astrocytes were exposed to 200 nM atorvastatin or simvastatin for 6 days and then assessed for ...
Krzysztof Wojcicki +4 more
doaj +2 more sources
COQ8A-Ataxia as a Manifestation of Primary Coenzyme Q Deficiency [PDF]
Metabolites, 2022 COQ8A-ataxia is a mitochondrial disease in which a defect in coenzyme Q10 synthesis leads to dysfunction of the respiratory chain. The disease is usually present as childhood-onset progressive ataxia with developmental regression and cerebellar atrophy ...
Justyna Paprocka +3 more
doaj +2 more sources
Complete enzyme clustering enhances coenzyme Q biosynthesis via substrate channeling [PDF]
Nature CommunicationsMetabolons - transient assemblies of sequential metabolic enzymes - facilitate the reactions of multi-step metabolic pathways, yet, how they mechanistically bolster metabolic flux remains unknown.
Dianzhuo Wang +10 more
doaj +2 more sources
Endogenous coenzyme Q content and exogenous bioavailability in D. melanogaster [PDF]
HeliyonDevelopment and aging significantly impact the cellular levels of Coenzyme Q (CoQ), which is associated with both pathological and physiological conditions.
Ilenia Cirilli +6 more
doaj +2 more sources