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The Ubiquitous and Multifaceted Coenzyme Q [PDF]
AntioxidantsCoenzyme Q10 (CoQ10) is composed of a benzoquinone ring and an isoprenoid side chain attached to carbon 3 of the ring [...]
Luca Tiano, Plácido Navas
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Biosynthesis, Deficiency, and Supplementation of Coenzyme Q [PDF]
Antioxidants, 2023 Originally identified as a key component of the mitochondrial respiratory chain, Coenzyme Q (CoQ or CoQ10 for human tissues) has recently been revealed to be essential for many different redox processes, not only in the mitochondria, but elsewhere within
Carmine Staiano +6 more
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How plants synthesize coenzyme Q [PDF]
Plant Communications, 2022 Coenzyme Q (CoQ) is a conserved redox-active lipid that has a wide distribution across the domains of life. CoQ plays a key role in the oxidative electron transfer chain and serves as a crucial antioxidant in cellular membranes.
Jing-Jing Xu +3 more
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Physiol RevCoenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and a long isoprenoid side chain. It is thus extremely hydrophobic and resides in membranes. It is best known for its complex function as an electron transporter in the mitochondrial electron transport chain (ETC) but is also required for several other crucial cellular ...
Wang Y, Lilienfeldt N, Hekimi S.
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Research Progress of Coenzyme Q in Diabetes Mellitus and Its Common Complications [PDF]
Diabetes, Metabolic Syndrome and ObesityJingdong Xia,1,2 Xiudan Li,1,2 Chunying Bai,2 Xuchen Han1 1Affiliated Hospital of Chifeng University, Chifeng, The Inner Mongol Autonomous Region, Chifeng, People’s Republic of China; 2Key Laboratory of Research on Human Genetic Diseases at Universities ...
Xia J, Li X, Bai C, Han X
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Coenzyme Q biochemistry and biosynthesis. [PDF]
Trends Biochem Sci, 2023 Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse cellular processes. Although most known for shuttling electrons between mitochondrial electron transport chain (ETC) complexes, the roles for CoQ are far more wide-reaching and ever-expanding.
Guerra RM, Pagliarini DJ.
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New Insights on the Uptake and Trafficking of Coenzyme Q [PDF]
Antioxidants, 2023 Coenzyme Q (CoQ) is an essential lipid with many cellular functions, such as electron transport for cellular respiration, antioxidant protection, redox homeostasis, and ferroptosis suppression.
Michael D. Guile +3 more
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COQ8A-Ataxia as a Manifestation of Primary Coenzyme Q Deficiency [PDF]
Metabolites, 2022 COQ8A-ataxia is a mitochondrial disease in which a defect in coenzyme Q10 synthesis leads to dysfunction of the respiratory chain. The disease is usually present as childhood-onset progressive ataxia with developmental regression and cerebellar atrophy ...
Justyna Paprocka +3 more
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Statin-Induced Coenzyme Q Deficiency Induces Metabolic Reprogramming in Astrocytes [PDF]
AntioxidantsStatins are commonly used cholesterol-lowering drugs, but their effects on astrocyte oxidative metabolism are poorly understood. To investigate this, rat astrocytes were exposed to 200 nM atorvastatin or simvastatin for 6 days and then assessed for ...
Krzysztof Wojcicki +4 more
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Endogenous coenzyme Q content and exogenous bioavailability in D. melanogaster [PDF]
HeliyonDevelopment and aging significantly impact the cellular levels of Coenzyme Q (CoQ), which is associated with both pathological and physiological conditions.
Ilenia Cirilli +6 more
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