Results 11 to 20 of about 1,766,693 (250)
Coenzyme Q and the Respiratory Chain: Coenzyme Q Pool and Mitochondrial Supercomplexes [PDF]
Molecular Syndromology, 2014 Two alternative models of organization of the mitochondrial electron transport chain (mETC) have been alternatively favored or questioned by the accumulation evidences of different sources, the solid model or the random collision model. Both agree in the number of respiratory complexes (I-IV) that participate in the mETC, but while the random collision
José Antonio, Enriquez, Giorgio, Lenaz
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Coenzyme Q 10: multiple benefits in one ingredient
Oléagineux, Corps gras, Lipides, 2011 Coenzyme Q is a lipid molecule widely diffused in nature; in humans and other mammals it is present as coenzyme Q10. (CoQ10). The first recognized role of CoQ10 was in mitochondrial bioenergetics, where it plays a central role in the production of ATP ...
Littarru Gian Paolo, Lambrechts Peter
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Physiol RevCoenzyme Q (CoQ), also known as ubiquinone, comprises a benzoquinone head group and a long isoprenoid side chain. It is thus extremely hydrophobic and resides in membranes. It is best known for its complex function as an electron transporter in the mitochondrial electron transport chain (ETC) but is also required for several other crucial cellular ...
Wang Y, Lilienfeldt N, Hekimi S.
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Antioxidants, 2021 The world continues a desperate search for therapies that could bring hope and relief to millions suffering from progressive neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD).
Darcy Wear +5 more
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Coenzyme Q at the Hinge of Health and Metabolic Diseases
Antioxidants, 2021 Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among
Juan Diego Hernández-Camacho +4 more
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American Journal of Respiratory and Critical Care Medicine, 2015 To the Editor: Asthma is a chronic inflammatory disease characterized by an increase of reactive oxygen and nitrogen species production in the airways (1–3). Oxidative stress has been proportionately linked to the severity of the disease (2, 3). The lung has effective, well-integrated antioxidant systems to combat oxidative and nitrative injury ...
Suzy A A, Comhair +5 more
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COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating. [PDF]
Sci AdvCoenzyme Q biosynthesis requires two atypical kinase-like proteins (COQ8A and COQ8B), whose detailed molecular mechanism remains unclear. Here, we show that both paralogs function as adenosine triphosphatases (ATPases) that promote coenzyme Q ...
Gottinger A +16 more
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Coenzyme Q biochemistry and biosynthesis. [PDF]
Trends Biochem Sci, 2023 Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse cellular processes. Although most known for shuttling electrons between mitochondrial electron transport chain (ETC) complexes, the roles for CoQ are far more wide-reaching and ever-expanding.
Guerra RM, Pagliarini DJ.
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Biology, 2021 At the end of the mammalian intra-uterine foetal development, a rapid switch from glycolytic to oxidative metabolism must proceed. Using microarray techniques, qPCR, enzyme activities and coenzyme Q content measurements, we describe perinatal ...
Jana Krizova +7 more
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Antihypoxic Activities of Coenzyme Q and Folic Acid in Asphyctic, Hemic, and Circulatory Hypoxia Models in Mice [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Hypoxia is a decrease in oxygen levels of body tissues which can lead to body function impairment. Coenzyme Q and folic acid are well-known drugs with distinctive antioxidant and anti-ischemic activities, but, nothing is known ...
Mahsa Modammadyan +3 more
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