Results 41 to 50 of about 1,766,693 (250)

Synthesis and properties of novel Coenzyme-Q derivatives obtained from Coenzyme Q-0 [PDF]

, 2013
Coenzyme Q-0 is an amphiphilic compound that is involved in the biosynthesis of Coenzyme Q-10 (CoQ10). CoQ10 transfers electrons along the ETC and protons across the inner mitochondrial membrane (IMM), while taking a crucial part in the oxidative ...
Naumova, Galaba, Gulaboski, Rubin, Kokoskarova, Pavlinka   +2 more
core   +1 more source

Composition and Antioxidant Properties of Spanish Extra Virgin Olive Oil Regarding Cultivar, Harvest Year and Crop Stage

Antioxidants, 2019
The health benefits of extra virgin olive oil (EVOO) are related to its chemical composition and the presence of bioactive compounds with antioxidant properties.
Thays Helena Borges, Adriana Serna, Luis Carlos López, Luis Lara, Rosa Nieto, Isabel Seiquer   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Effect of electroacupuncture on total motile sperm count and sperm motility

Journal of Public Health Research
Background: Approximately 50% of infertility cases are attributed to male factors. Acupuncture has long been employed as a complementary therapy to enhance male infertility treatment outcomes.
Uki Retno Budihastuti, Bhisma Murti, Teguh Prakosa, Ida Nurwati, Abdurahman Laqif, Eriana Melinawati, Cahyono Hadi, Lunardhi Susanto, Metanolia Sukmawati, Hanung Prasetya, Agung Sari Wijayanti, Miftahul Falah Ahmad   +11 more
doaj   +1 more source

The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase coq7 in yeast

, 2013
The study of the components of mitochondrial metabolism has potential benefits for health span and lifespan because the maintenance of efficient mitochondrial function and antioxidant capacity is associated with improved health and survival.
Padilla, Sergio, Navas, Plácido, González-Mariscal, Isabel, Ballesteros, Manuel, Martín-Montalvo, Alejandro, Brautigan, David L., Santos-Ocaña, Carlos   +6 more
core   +1 more source

Molecular Structure, Biosynthesis, and Distribution of Coenzyme Q

, 2020
Coenzyme Q is a very old molecule in evolutionary terms that has accumulated numerous functions in the cellular metabolism beyond its primordial function, the electron transport.
L. Vázquez-Fonseca, González-Mariscal, Isabel, C. Santos-Ocaña, Vázquez-Fonseca, Luis, I. González-Mariscal, Santos-Ocaña, Carlos   +5 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Mitochondrial Coenzyme Q Redox Homeostasis and Reactive Oxygen Species Production

Frontiers in Bioscience-Landmark, 2023
Mitochondrial coenzyme Q (mtQ) of the inner mitochondrial membrane is a redox active mobile carrier in the respiratory chain that transfers electrons between reducing dehydrogenases and oxidizing pathway(s). mtQ is also involved in mitochondrial reactive
Wieslawa Jarmuszkiewicz, Karolina Dominiak, Adrianna Budzinska, Krzysztof Wojcicki, Lukasz Galganski   +4 more
doaj   +1 more source