Results 51 to 60 of about 1,766,693 (250)
New Insights into the Chemistry and Functions of Coenzyme Q
, 2015 The oxidative phosphorylation is a crucial physiological process that leads to energy production in the living cells. In this processes, Coenzyme Q10 acts as a redox mediator in the mitochondrial membrane, where it facilitates the electron transfer ...
Gulaboski, Rubin
core +3 more sources
Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges
Advanced Science, EarlyView.Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen +6 more
wiley +1 more source
Benzoic acid inhibits Coenzyme Q biosynthesis in Schizosaccharomyces pombe.
PLoS ONE, 2020 Coenzyme Q (CoQ, ubiquinone) is an essential component of the electron transport system in aerobic organisms. Human type CoQ10, which has 10 units of isoprene in its quinone structure, is especially valuable as a food supplement.
Ikuhisa Nishida +4 more
doaj +1 more source
Ubiquinone (Coenzyme Q) in Insects [PDF]
Nature, 1960 Lester and Crane1 found that while tissues of vertebrates contain mostly the Q 10-homologue of ubiquinone (coenzyme Q), certain insects, notably the house-fly, Musca domestica, and the cabbage white butterfly, Pieris rapae, are characterized by the presence of the Q 9 homologue, that is, a ubiquinone with a side-chain of 9, instead of 10, isoprenoid ...
J, HELLER, L, SZARKOWSKA, H, MICHALEK
openaire +2 more sources
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
Antioxidative stress-induced damage in cochlear explants
Journal of Otology, 2020 The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress.
Dalian Ding +10 more
doaj +1 more source
Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings
Antioxidants, 2021 Coenzyme Q (CoQ) is a vital lipophilic molecule that is endogenously synthesized in the mitochondria of each cell. The CoQ biosynthetic pathway is complex and not completely characterized, and it involves at least thirteen catalytic and regulatory ...
Pilar González-García +5 more
doaj +1 more source
The effect of the antioxidant, Coenzyme Q, on Coco-2 colon cells treated with iron to reduce lipid peroxidation [PDF]
, 2002 Plan BThe objective of this study was to determine if Coenzyme Q10 (also known as ubiquinone) acting as an antioxidant, would protect against free radical damage to cell membranes that can cause cancer.
Johanknecht, Viva M.
core
The participation of coenzyme Q in free radical production and antioxidation
, 1990 Published experimental data pertaining to the participation of coenzyme Q as a site of free radical formation in the mitochondrial electron transfer chain and the conditions required for free radical production have been reviewed critically. The evidence
Beyer, Robert E.
core +1 more source
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source