Results 61 to 70 of about 1,766,693 (250)

Chapter Nine - Coenzyme Q-related compounds to maintain healthy mitochondria during aging

, 2023
Mitochondrial dysfunction is one of the main factors that affects aging progression and many age-related diseases. Accumulation of dysfunctional mitochondria can be driven by unbalanced mito/autophagy or by decrease in mitochondrial biosynthesis and ...
López-Lluch, Guillermo
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Effects of Coenzyme Q10 on LDL Oxidation In vitro

Acta Medica Iranica, 2013
Coenzyme Q10, a lipid soluble benzoquinone, has excellent antioxidant and membrane stabilizing properties in the cardiac tissue. The present study investigated the effects of coenzyme Q10 on in vitro LDL oxidation quantitavely.
Hiroshi Mabuchi, Junji Kobayahi, Masa-aki Kawashiri, Hassan Ahmadvand   +3 more
doaj   +2 more sources

Coenzyme Q in the Treatment of Mitochondrial Disease

Journal of Inborn Errors of Metabolism and Screening, 2017
Currently, there is a paucity of available treatment strategies for oxidative phosphorylation disorders. Coenzyme Q 10 (CoQ 10 ) and related synthetic quinones are the only agents to date that have proven to be beneficial in the treatment of these ...
Viruna Neergheen MSc, Annapurna Chalasani MSc, Luke Wainwright MSci, MRes, Delia Yubero PhD, Raquel Montero PhD, Rafael Artuch MD, PhD, Iain Hargreaves PhD   +6 more
doaj   +1 more source

Pathways of hepatic cholesterol and Coenzyme Q₁₀ (CoQ10) biosynthesis in liver.

, 2014
Pathways of hepatic cholesterol and Coenzyme Q10 (CoQ10) biosynthesis in liver.
Qixuan Chen (629874), Mahemuti Laziyan (629877), Nimal Ratnayake (629884), Maria Florian (629873), Ryan J. Mailloux (50825), Melanie C. Coughlan (629876), Jocelyn Truong (629882), Don Caldwell (455020), Ivan Petrov (629875), Nanqin Li (629885), Claude Gagnon (629880), William G. Willmore (190943), Jin Yan (193119), Hing Man Chan (629883), Kurtis Sarafin (629881), Michelle Lalande (629878), Dominique Patry (629879), Xiaolei Jin (428624)   +17 more
core   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Coenzyme Q deficiency in muscle

Current Opinion in Neurology, 2011
Coenzyme Q (CoQ) is a vital component of the mitochondrial respiratory chain. A number of patients with CoQ deficiency presented with different clinical phenotypes, often affecting skeletal muscle, and responded well to CoQ supplementation. We discuss recent advances in this field with special attention to muscle involvement.The identification of ...
TREVISSON, EVA, Salvatore DiMauro, Placido Navas, SALVIATI, LEONARDO   +3 more
openaire   +4 more sources

COENZYME Q (UBIQUINONE) LEVELS OF TISSUES OF RATS DURING ACCLIMATION TO COLD

, 1962
Coenzyme Q (ubiquinone) levels have been determined in rat liver, skeletal muscle, heart muscle, kidney, and brain after various periods of exposure to 0–2 °C.
Robert E. Beyer, Thomas J. Hirschfeld, Walter M. Noble   +2 more
core   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source