Results 81 to 90 of about 1,766,693 (250)
The Important Role of CoQ10 in Aging
Antioxidants, 2019 Coenzyme Q10 (CoQ10) is an essential lipid present in all cell membranes[...]
Guillermo López-Lluch
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Advanced Science, EarlyView.LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao +12 more
wiley +1 more source
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
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Plasma membrane coenzyme Q: evidence for a role in autism
Biologics: Targets & Therapy, 2014 Frederick L Crane,1 Hans Löw,2 Iris Sun,1 Placido Navas,3 Anna Gvozdjáková41Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; 2Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden ...
Crane FL +4 more
doaj
Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury
Advanced Science, EarlyView.Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin +16 more
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4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures
, 2010 Coenzyme Q (Q) is an electron transporter in the respiratory chain and a lipid-soluble antioxidant that decreases in humans with age. Here we show that 4-nitrobenzoate inhibited 4-hydroxybenzoate: polyprenyl transferase (Coq2) in a competitive manner and
Ulrika Forsman +11 more
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Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
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Advanced NanoBiomed Research, EarlyView.This study presents a label‐free spectroscopic platform to evaluate membrane protein conformation on patient‐derived glioblastoma cell membrane‐coated magnetic nanovectors. This work demonstrates that preserving membrane protein integrity during nanoparticle fabrication enhances homotypic tumor targeting and reduces hard protein corona formation ...
Daniele De Pasquale +16 more
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Animal Research and One Health, EarlyView.Schematic summary of the effects of organic acids on growth performance and gut health‐related parameters in broilers. ABSTRACT This study was conducted to evaluate the effects of an organic acid blend on growth performance, redox homeostasis, and intestinal microbiota of broilers raised in an antibiotic‐free system during the winter season in China ...
Rong‐Hui Huang +11 more
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Intestinal absorption of coenzyme Q(10) administered in a meal or as capsules to healthy subjects
, 1997 A randomized cross-over study by supplementation with single doses of coenzyme Q(10) (30 mg/person), administered either as a meal consisting of cooked pork heart or as 30 mg coenzyme Q(10) capsules was performed to investigate the bioavailability of ...
Anette Bysted +5 more
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