Results 21 to 30 of about 41,185 (159)
The Use of Coenzyme Q10 in Cardiovascular Diseases
Antioxidants, 2021 CoQ10 is an endogenous antioxidant produced in all cells that plays an essential role in energy metabolism and antioxidant protection. CoQ10 distribution is not uniform among different organs, and the highest concentration is observed in the heart ...
Yoana Rabanal-Ruiz +2 more
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BMC Cancer, 2020 Background Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer ...
Man-Yee Chan +6 more
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Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress
Регуляторные исследования и экспертиза лекарственных средств, 2019 The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants.
O. A. Goroshko +3 more
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Acid-Sensing Histidine Kinase With a Redox Switch
Frontiers in Microbiology, 2021 The EvgS/EvgA two-component signal transduction system in Escherichia coli is activated under mildly acidic pH conditions. Upon activation, this system induces the expression of a number of genes that confer acid resistance.
Shinya Inada +3 more
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Journal of Lipid Research, 1968 The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-l-14C and mevalonate-2-14C incorporation studies both in vivo and in vitro confirm the results of
M.R. Lakshmanan +2 more
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Coenzyme Q at the Hinge of Health and Metabolic Diseases
Antioxidants, 2021 Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among
Juan Diego Hernández-Camacho +4 more
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Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders
Frontiers in Bioscience-Landmark, 2022 Coenzyme Q10 (CoQ10) deficiency is broadly divided into two types, primary and secondary. Primary CoQ10 deficiencies are relatively rare disorders resulting from mutations in genes directly involved in the CoQ10 biosynthetic pathway, and are not a ...
David Mantle +2 more
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Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes
Antioxidants, 2022 Coenzyme Q (CoQ) is a vital lipid that functions as an electron carrier in the mitochondrial electron transport chain and as a membrane-soluble antioxidant.
Sining Wang +5 more
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Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo1
Journal of Lipid Research, 1998 A randomized, double-masked, placebo-controlled cross-over trial was carried out to evaluate whether ubiquinone supplementation (180 mg daily) corrects impaired defence against initiation of oxidation of low density lipoprotein (LDL) related to effective
Ari Palomäki +3 more
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Journal of Lipid Research, 1991 Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger +7 more
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