Results 21 to 30 of about 36,766 (230)

Acid-Sensing Histidine Kinase With a Redox Switch

Frontiers in Microbiology, 2021
The EvgS/EvgA two-component signal transduction system in Escherichia coli is activated under mildly acidic pH conditions. Upon activation, this system induces the expression of a number of genes that confer acid resistance.
Shinya Inada, Toshihide Okajima, Ryutaro Utsumi, Yoko Eguchi   +3 more
doaj   +1 more source

Coenzyme Q at the Hinge of Health and Metabolic Diseases

Antioxidants, 2021
Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among
Juan Diego Hernández-Camacho, Laura García-Corzo, Daniel José Moreno Fernández-Ayala, Plácido Navas, Guillermo López-Lluch   +4 more
doaj   +1 more source

Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo1

Journal of Lipid Research, 1998
A randomized, double-masked, placebo-controlled cross-over trial was carried out to evaluate whether ubiquinone supplementation (180 mg daily) corrects impaired defence against initiation of oxidation of low density lipoprotein (LDL) related to effective
Ari Palomäki, Kimmo Malminiemi, Tiina Solakivi, Outi Malminiemi   +3 more
doaj   +1 more source

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Frontiers in Bioscience-Landmark, 2022
Coenzyme Q10 (CoQ10) deficiency is broadly divided into two types, primary and secondary. Primary CoQ10 deficiencies are relatively rare disorders resulting from mutations in genes directly involved in the CoQ10 biosynthetic pathway, and are not a ...
David Mantle, Nadia Turton, Iain P. Hargreaves   +2 more
doaj   +1 more source

Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.

Journal of Lipid Research, 1991
Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger, A Kalén, E Lund, E Reihnér, M Eriksson, L Berglund, B Angelin, G Dallner   +7 more
doaj   +1 more source

Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes

Antioxidants, 2022
Coenzyme Q (CoQ) is a vital lipid that functions as an electron carrier in the mitochondrial electron transport chain and as a membrane-soluble antioxidant.
Sining Wang, Akash Jain, Noelle Alexa Novales, Audrey N. Nashner, Fiona Tran, Catherine F. Clarke   +5 more
doaj   +1 more source

Ubiquinone Biosynthesis over the Entire O₂ Range: Characterization of a Conserved O₂-Independent Pathway

mBio, 2019
Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubiquinone.
Ludovic Pelosi, Chau-Duy-Tam Vo, Sophie Saphia Abby, Laurent Loiseau, Bérengère Rascalou, Mahmoud Hajj Chehade, Bruno Faivre, Mathieu Goussé, Clothilde Chenal, Nadia Touati, Laurent Binet, David Cornu, Cameron David Fyfe, Marc Fontecave, Frédéric Barras, Murielle Lombard, Fabien Pierrel   +16 more
doaj   +1 more source

Effects of Coenzyme Q₁₀ Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease

Antioxidants, 2022
Scarce data exist on the effects of coenzyme Q10 (CoQ10) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ10 supplementation on oxidative stress markers (glutathione ...
Natalia Druzhaeva, Alenka Nemec Svete, Gabrijela Tavčar-Kalcher, Janja Babič, Alojz Ihan, Katka Pohar, Uroš Krapež, Aleksandra Domanjko Petrič   +7 more
doaj   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study

Redox Report, 2016
Objectives: To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial.
Adolfo Daniel Rodríguez-Carrizalez, José Alberto Castellanos-González, Esaú César Martínez-Romero, Guillermo Miller-Arrevillaga, Luis Miguel Román-Pintos, Fermín Paul Pacheco-Moisés, Alejandra Guillermina Miranda-Díaz   +6 more
doaj   +1 more source