Results 131 to 140 of about 15,890 (276)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Determination of the content of coenzymes Q9 and Q10 in pork meat from different breeds

, 2014
Meat contains basic and essential nutrients to humans, and recently has been given a special attention to the presence of bioactive compounds. The objective of this work was the simultaneous determination of coenzymes Q9 and Q10 in pork meat, using HPLC.
Guiné, Raquel, Andrade, Sónia, Roseiro, Luísa   +2 more
core   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

2-oxoglutarate coenzymes interaction on the multienzyme complex level and in the liver mitochondria

, 2004
Досліджено механізми коферментної регуляції мультиензимного 2-оксоглутаратдегідрогеназного комплексу. Показана стимулююча роль ліпоєвої кислоти і КоА на досліджуваний фермент у мітохондріях печінки.
Петров, Сергей Анатольевич, Fedorko, Natalia L., Petrov, Serhii A., Федорко, Наталія Леонідівна, Федорко, Наталья Леонидовна, Петров, Сергій Анатолійович   +5 more
core   +1 more source

Rationales for the Choice of Metals for Super‐Reduced Biological Metal Centers: Cobalt in Cobalamin Versus Nickel in F430

Chemistry – A European Journal, EarlyView.
DFT calculations on porphyrin, corrin, and corphin complexes of cobalt, rhodium, iron, manganese, or nickel, and QM/MM calculations on enzyme models, explore the factors controlling the availably of super‐reduced metal(I) states. True metal(I) states are seen in corrin only for cobalt, in corphin only for nickel, and not at all in porphyrin.
Radu‐Ioan Onija, Sergiu‐Raul Cosma, Adrian M. V. Brânzanic, Radu Silaghi‐Dumitrescu   +3 more
wiley   +1 more source

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source

MECHANISMS OF ENZYME ACTION. STRUCTURE OF COENZYMES. ACTIVE SITES OF ENZYMES

This paper examines the mechanisms of enzyme action, the structure of their active sites, and the organization of coenzymes. The features of enzyme–substrate interactions, the stages of catalytic processes, and the role of coenzymes in enzymatic ...
Asadova Ruhsora Avazovna, Bakayeva Shoira Baxshilloyevna, Achilova Azimabonu Akmalovna   +2 more
core  

The Dynamic Coenzyme Network of B Vitamins in Nutritional Neuropathy and Neuropsychiatric Vulnerability: A Mechanistic Narrative Review. [PDF]

Nutrients
Yoon Y, Hwang J, Park R, Shim J, Lam KHS, de Castro JC, Suryadi T, Suhaimi A, Yang CM.   +8 more
europepmc   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

A Nonenzymatic Analogue of the Biosynthesis of Pyridoxal Vitamers. [PDF]

J Am Chem Soc
Nogal N, Basar AB, Minic Z, Moran J.
europepmc   +1 more source