Results 11 to 20 of about 349,815 (226)

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme [PDF]

, 2019
Cobamides, a uniquely diverse family of enzyme cofactors related to vitamin B12, are produced exclusively by bacteria and archaea but used in all domains of life.
Olga M. Sokolovskaya, Kenny C. Mok, Jong Duk Park, Jennifer L. A. Tran, Kathryn Quanstrom, Michiko E. Taga   +5 more
openalex   +4 more sources

Identification of YdhV as the first molybdoenzyme binding a Bis-Mo-MPT cofactor in escherichia coli [PDF]

, 2019
The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Dau, Holger, Duffus, Benjamin R., Haumann, Michael, Leimkühler, Silke, Mebs, Stefan, Reschke, Stefan, Schrapers, Peer, Teutloff, Christian   +7 more
core   +1 more source

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

Frontiers in Allergy, 2023
BackgroundDrug hypersensitivity reactions (DHRs) are major medical problems that influence the treatment of patients by both under- and overdiagnosis.
Johanna Kühl, Björn Bergh, Matthias Laudes, Silke Szymczak, Guido Heine   +4 more
doaj   +1 more source

Biochemical Characterization and Structural Insight into Interaction and Conformation Mechanisms of Serratia marcescens Lysine Decarboxylase (SmcadA)

Molecules, 2021
Inducible lysine decarboxylases (LDCs) are essential in various cellular processes of microorganisms and plants, especially under acid stress, which induces the expression of genes encoding LDCs.
Tolbert Osire, Zhina Qiao, Taowei Yang, Meijuan Xu, Xian Zhang, Zhiming Rao   +5 more
doaj   +1 more source

Mechanisms, Cofactors, and Augmenting Factors Involved in Anaphylaxis

Frontiers in Immunology, 2017
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and
Rosa Muñoz-Cano, Rosa Muñoz-Cano, Mariona Pascal, Mariona Pascal, Giovanna Araujo, Giovanna Araujo, M. J. Goikoetxea, Antonio L. Valero, Antonio L. Valero, Cesar Picado, Cesar Picado, Joan Bartra, Joan Bartra   +12 more
doaj   +1 more source

Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells

Frontiers in Immunology, 2021
Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of
Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Clara San Bartolome, Clara San Bartolome, Clara San Bartolome, Rocío Casas-Saucedo, Rocío Casas-Saucedo, Rocío Casas-Saucedo, Giovanna Araujo, Giovanna Araujo, Sonia Gelis, Sonia Gelis, Maria Ruano-Zaragoza, Maria Ruano-Zaragoza, Maria Ruano-Zaragoza, Jordi Roca-Ferrer, Jordi Roca-Ferrer, Jordi Roca-Ferrer, Francis Palomares, Francis Palomares, Margarita Martin, Margarita Martin, Margarita Martin, Joan Bartra, Joan Bartra, Joan Bartra, Joan Bartra, Mariona Pascal, Mariona Pascal, Mariona Pascal   +31 more
doaj   +1 more source

The Geometry of the Catalytic Active Site in [FeFe]-hydrogenases is Determined by Hydrogen Bonding and Proton Transfer [PDF]

, 2019
[FeFe]-hydrogenases are efficient metalloenzymes that catalyze the oxidation and evolution of molecular hydrogen, H2. They serve as a blueprint for the design of synthetic H2-forming catalysts.
Apfel, Ulf-Peter, Duan, Jifu, Happe, Thomas, Haumann, Michael, Heberle, Joachim, Hofmann, Eckhard, Laun, Konstantin, Mebs, Stefan, Senger, Moritz, Stripp, Sven T., Winkler, Martin, Wittkamp, Florian   +11 more
core   +2 more sources

A 7-Deazaadenosylaziridine Cofactor for Sequence-Specific Labeling of DNA by the DNA Cytosine-C5 Methyltransferase M.HhaI

Molecules, 2015
DNA methyltransferases (MTases) catalyze the transfer of the activated methyl group of the cofactor S-adenosyl-l-methionine (AdoMet or SAM) to the exocyclic amino groups of adenine or cytosine or the C5 ring atom of cytosine within specific DNA sequences.
Falk Kunkel, Rudi Lurz, Elmar Weinhold
doaj   +1 more source

Pteridines CVII* Synthesis of 6-Azidomethyl-5,6,7,8-tetrahydropterin. Photo degradation Products and Cofactor Properties on Aromatic Amino Acid Monooxygenases

Pteridines, 1995
The synthesis of 6-azidomethyl-5,6,7,8-tetrahydropterin (6-AzmH4Ptr) (9) starting from 2,4-diamino- 6-hydroxymethylpteridine (1) is described. A special protecting group strategy had to be applied to perform the structural modifications. The introduction
Heizmann Gerhard, Groehn Viola, Almås Bjørg, Haavik Jan, Flatmark Torgeir, Pfleiderer Wolfgang   +5 more
doaj   +1 more source

Identity and function of an essential nitrogen ligand of the nitrogenase cofactor biosynthesis protein NifB. [PDF]

, 2020
NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential for nitrogenase cofactor assembly. Previously, a nitrogen ligand was shown to be involved in coupling a pair of [Fe4S4] clusters (designated K1 and K2) concomitant with carbide ...
Britt, R David, Hu, Yilin, Jasniewski, Andrew J, Lee, Chi Chung, Rettberg, Lee A, Ribbe, Markus W, Tanifuji, Kazuki, Wilcoxen, Jarett   +7 more
core   +1 more source