Results 11 to 20 of about 418,378 (371)
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated
Adams, Clare M. +9 more
core +3 more sources
Peroxisomal Cofactor Transport [PDF]
Biomolecules, 2020 Peroxisomes are eukaryotic organelles that are essential for growth and development. They are highly metabolically active and house many biochemical reactions, including lipid metabolism and synthesis of signaling molecules.
Anastasija Plett +2 more
doaj +3 more sources
The CoFactor database: organic cofactors in enzyme catalysis [PDF]
Bioinformatics, 2010 Abstract Motivation: Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database. Results: CoFactor provides a web interface to access hand-curated data extracted from ...
Gemma L. Holliday +2 more
openaire +3 more sources
Biosynthesis of Nitrogenase Cofactors [PDF]
Chemical Reviews, 2020 Nitrogenase harbors three distinct metal prosthetic groups that are required for its activity. The simplest one is a [4Fe-4S] cluster located at the Fe protein nitrogenase component. The MoFe protein component carries an [8Fe-7S] group called P-cluster and a [7Fe-9S-C-Mo-R-homocitrate] group called FeMo-co.
Stefan Burén +3 more
openaire +4 more sources
Angewandte Chemie, 2020 Metal-organic frameworks (MOFs) have recently emerged as excellent hosting matrices for enzyme immobilization, offering superior physical and chemical protection for biocatalytic reactions.
Jieying Liang +9 more
semanticscholar +1 more source
Geobiology, 2020 The nitrogenase metalloenzyme family, essential for supplying fixed nitrogen to the biosphere, is one of life's key biogeochemical innovations. The three forms of nitrogenase differ in their metal dependence, each binding either a FeMo‐, FeV‐, or FeFe ...
Amanda K. Garcia +3 more
semanticscholar +1 more source
The electronic complexity of the ground-state of the FeMo cofactor of nitrogenase as relevant to quantum simulations. [PDF]
Journal of Chemical Physics, 2018 We report that a recent active space model of the nitrogenase FeMo cofactor, proposed in the context of simulations on quantum computers, is not representative of the electronic structure of the FeMo cofactor ground-state.
Zhendong Li +4 more
semanticscholar +1 more source
Nucleic Acids Res., 2017 The COFACTOR web server is a unified platform for structure-based multiple-level protein function predictions. By structurally threading low-resolution structural models through the BioLiP library, the COFACTOR server infers three categories of protein ...
Chengxin Zhang +2 more
semanticscholar +1 more source
Frontiers in Microbiology, 2018 Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
Andrea M. Chánique +2 more
doaj +1 more source
Molecules, 2021 Inducible lysine decarboxylases (LDCs) are essential in various cellular processes of microorganisms and plants, especially under acid stress, which induces the expression of genes encoding LDCs.
Tolbert Osire +5 more
doaj +1 more source