Results 21 to 30 of about 341,197 (295)
Identity and function of an essential nitrogen ligand of the nitrogenase cofactor biosynthesis protein NifB. [PDF]
, 2020 NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential for nitrogenase cofactor assembly. Previously, a nitrogen ligand was shown to be involved in coupling a pair of [Fe4S4] clusters (designated K1 and K2) concomitant with carbide ...
Britt, R David +7 more
core +1 more source
Molecular architecture of human polycomb repressive complex 2. [PDF]
, 2012 Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2.
Aebersold, Ruedi +5 more
core +1 more source
The role of algebraic solutions in planar polynomial differential systems [PDF]
, 2005 We study a planar polynomial differential system, given by \dot{x}=P(x,y), \dot{y}=Q(x,y). We consider a function I(x,y)=\exp \{h_2(x) A_1(x,y) \diagup A_0(x,y) \} h_1(x) \prod_{i=1}^{\ell} (y-g_i(x))^{\alpha_i}, where g_i(x) are algebraic functions, A_1(
Giacomini, Héctor +2 more
core +5 more sources
Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin
Pharmaceuticals, 2021 Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi +6 more
doaj +1 more source
Cofactor and Cofactor Mimetics
Blood, 2019 Many natural enzymes need the assistance of protein cofactors to catalyze chemical reactions at a physiologically relevant speed and several of the enzymes that make up for the coagulation cascade are no exception in this regard. Notably, activated factors VII, IX and X display relatively poor enzymatic activity towards their respective macromolecular ...
openaire +1 more source
Frontiers in Microbiology, 2018 Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
Andrea M. Chánique +2 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity ...
Katelyn A. Bustin +6 more
doaj +1 more source
Non-Hamiltonian systems separable by Hamilton-Jacobi method
, 2007 We show that with every separable calssical Stackel system of Benenti type on a Riemannian space one can associate, by a proper deformation of the metric tensor, a multi-parameter family of non-Hamiltonian systems on the same space, sharing the same ...
Beltrami +20 more
core +1 more source
Nutrient cross-feeding in the microbial world. [PDF]
, 2014 The stability and function of a microbial community depends on nutritional interactions among community members such as the cross-feeding of essential small molecules synthesized by a subset of the population.
Seth, Erica C, Taga, Michiko E
core +2 more sources
Research and Practice in Thrombosis and HaemostasisBackground: Combined oral contraceptives (COCs) are associated with an increased risk of venous thromboembolism. Several changes are induced in both coagulant and anticoagulant factors, of which the impact on protein S (PS) and tissue factor pathway ...
Jesper Strandberg +3 more
doaj +1 more source