Results 11 to 20 of about 221,534 (298)
Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin
Pharmaceuticals, 2021 Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi +6 more
doaj +2 more sources
Peroxisomal Cofactor Transport [PDF]
Biomolecules, 2020 Peroxisomes are eukaryotic organelles that are essential for growth and development. They are highly metabolically active and house many biochemical reactions, including lipid metabolism and synthesis of signaling molecules.
Anastasija Plett +2 more
doaj +3 more sources
Hierarchies of cofactor systems
Journal of Physics A: Mathematical and General, 2002 Summary: We assign to any cofactor system a whole hierarchy of such systems. A sufficient condition for their complete integrability is given. The hierarchies admit construction of nontrivial integrable systems from trivial ones.
Topalov, P
openaire +4 more sources
The CoFactor database: organic cofactors in enzyme catalysis [PDF]
Bioinformatics, 2010 Abstract Motivation: Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database. Results: CoFactor provides a web interface to access hand-curated data extracted from ...
Julia D. Fischer +2 more
openaire +3 more sources
Structural insights into cofactor activity [PDF]
, 2016 Regulators of complement activation (RCA) modulate the innate immune response to avoid self-injury from inadvertent attack. These RCA proteins exert two distinct activities to control complement activity: (1) enhance dissociation of the C3 convertases ...
Xiaoguang Xue, +7 more
core +1 more source
, 2020 Insects wings qualify as novel structures and their origin is unknown. Recent work has found tissues serially homologous to the wing (named wing serial homologs, or WSHs) in the wingless body segments of Tribolium castaneum (red flour beetle), and here I
Madison Moe (8727752) +1 more
core +1 more source
Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]
, 2000 We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
French, C E +4 more
core +1 more source
eLife, 2021 Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane ...
Achinta Sannigrahi +9 more
doaj +1 more source
Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases [PDF]
, 2019 Here we present the synthesis of two functional cofactor-based chemical probes and their usage as mechanistic tools in a broadly applica-ble assay platform for histone acetyltransferases (HATs).
Tobias, Rumpf +5 more
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Cofactor-Mediated Nucleophilic Substitution Catalyzed by a Self-Assembled Holoenzyme Mimic
, 2019 A self-assembled Fe4L6 cage is capable of co-encapsulating multiple carboxylic acid containing guests in its cavity, and these acids can act as cofactors for cage-catalyzed nucleophilic substitutions.
Paul M. Bogie (4242151) +5 more
core +2 more sources