Results 31 to 40 of about 184,152 (265)

OPTIMIZATION OF ENZYME PARAMETERS FOR FERMENTATIVE PRODUCTION OF BIORENEWABLE FUELS AND CHEMICALS

Computational and Structural Biotechnology Journal, 2012
Microbial biocatalysts such as Escherichia coli and Saccharomyces cerevisiae have been extensively subjected to Metabolic Engineering for the fermentative production of biorenewable fuels and chemicals. This often entails the introduction of new enzymes,
Laura R. Jarboe, Ping Liu, Kumar Babu Kautharapu, Lonnie O. Ingram   +3 more
doaj   +1 more source

Cofactor and Cofactor Mimetics

Blood, 2019
Many natural enzymes need the assistance of protein cofactors to catalyze chemical reactions at a physiologically relevant speed and several of the enzymes that make up for the coagulation cascade are no exception in this regard. Notably, activated factors VII, IX and X display relatively poor enzymatic activity towards their respective macromolecular ...
openaire   +1 more source

The impact of protein S and tissue factor pathway inhibitor on coagulation, assessed with thrombin generation, in women starting combined oral contraceptives

Research and Practice in Thrombosis and Haemostasis
Background: Combined oral contraceptives (COCs) are associated with an increased risk of venous thromboembolism. Several changes are induced in both coagulant and anticoagulant factors, of which the impact on protein S (PS) and tissue factor pathway ...
Jesper Strandberg, Jette Nybo, Inger Lise Gade, Søren Risom Kristensen   +3 more
doaj   +1 more source

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Pharmaceuticals, 2021
Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi, Ibrahim M. El-Deeb, Veronika Masic, Lauren Hartley-Tassell, Andrea Maggioni, Mark von Itzstein, Thomas Ve   +6 more
doaj   +1 more source

Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

Frontiers in Pharmacology, 2023
Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity ...
Katelyn A. Bustin, Arwa Abbas, Xie Wang, Michael C. Abt, Joseph P. Zackular, Joseph P. Zackular, Megan L. Matthews   +6 more
doaj   +1 more source

CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

Cell Genomics, 2022
Summary: Non-coding DNA variants (NCVs) impact gene expression by altering binding sites for regulatory complexes. New high-throughput methods are needed to characterize the impact of NCVs on regulatory complexes.
David Bray, Heather Hook, Rose Zhao, Jessica L. Keenan, Ashley Penvose, Yemi Osayame, Nima Mohaghegh, Xiaoting Chen, Sreeja Parameswaran, Leah C. Kottyan, Matthew T. Weirauch, Trevor Siggers   +11 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma

BMC Cancer
Background While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15–20% benefit from such treatments.
Jeffrey Hiken, Jon Earls, Kevin C. Flanagan, Rachel L. Wellinghoff, Michelle Ponder, David N. Messina, Jarret I. Glasscock, Eric J. Duncavage   +7 more
doaj   +1 more source

Linearizability conditions for 1:-5 Lotka-Volterra two-dimensional complex quartic systems

上海师范大学学报. 自然科学版, 2017
In this paper we investigate the linearizability problem for the planar Lotka-Volterra complex quartic systems which are 1:-5 linear systems perturbed by homogeneous polynomials of degree 4, that is to say, we consider systems of the form ẋ = x(1 ...
Hu Zhaoping, Zhang Chao
doaj   +1 more source

Genome-Scale Mining of Acetogens of the Genus Clostridium Unveils Distinctive Traits in [FeFe]- and [NiFe]-Hydrogenase Content and Maturation

Microbiology Spectrum, 2022
Knowledge of the organizational and functional properties of hydrogen metabolism is pivotal to the construction of a framework supportive of a hydrogen-fueled low-carbon economy. Hydrogen metabolism relies on the mechanism of action of hydrogenases.
Pier Francesco Di Leonardo, Giacomo Antonicelli, Valeria Agostino, Angela Re   +3 more
doaj   +1 more source