Results 201 to 210 of about 188,158 (291)

Manipulating Cofactor Binding Thermodynamics in an Artificial Oxygen Transport Protein

, 2011
Lei Zhang, J. L. Ross Anderson, Ismail Y. Ahmed, Jessica Norman, Christopher Negron, Andrew C. Mutter, P. Leslie Dutton, Ronald L. Koder   +7 more
openalex   +2 more sources

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Prediction of UGT-mediated phase II metabolism via ligand- and structure-based predictive models. [PDF]

J Cheminform
Bono L, Lunghini F, Sabato E, Biswas AD, Mazzolari A, Pedretti A, Beccari AR, Vistoli G, Vittorio S.   +8 more
europepmc   +1 more source

Biosynthesis of ethylene. Methanesulphinic acid as cofactor in the enzymic formation of ethylene from methional

, 1969
L. W. Mapson, R. Self, D. A. Wardale
openalex   +2 more sources

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere. [PDF]

Nucleic Acids Res
Trasviña-Arenas CH, Hashemian M, Malek M, Merrill S, Fisher AJ, David SS.   +5 more
europepmc   +1 more source

Sphingolipid cofactors [PDF]

Nature Chemical Biology, 2012
openaire   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Reduction of NAD and NMN on mineral surfaces with H₂ reveals a functional role for the AMP moiety in a prebiotic context. [PDF]

Commun Chem
Henriques Pereira DP, Xie X, Stewart SV, Subrati Z, Beyazay T, Paczia N, Belz J, Volz K, Erastova V, Tüysüz H, Preiner M.   +10 more
europepmc   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source