Results 181 to 190 of about 341,197 (295)

Cofactor

Revista de Ciência Elementar, 2015
openaire   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Structural insights into metallocluster trafficking in the nitrogenase assembly scaffold NifEN. [PDF]

Nat Catal
Neumann B, Brandon KA, Quechol R, Suder DS, Lee CC, Yang Y, Górecki K, Wiig JA, Hu Y, Gonen S, Ribbe MW.   +10 more
europepmc   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Carrier-Free Enzyme Immobilization for High-Density Catalytic Architectures in Flow Biocatalysis. [PDF]

JACS Au
Stalter SP, Rabe KS, Niemeyer CM.
europepmc   +1 more source

Quantum Nanomedicine and Quantum Biomaterials

Advanced Science, EarlyView.
In this perspective, we define quantum nanomedicine and quantum biomaterials as a paradigm that harnesses quantum effects in nanomedicine and biomaterials, including quantum superposition, quantum coherence, quantum tunneling, topological quantum effects, and spin polarization, to achieve either spatiotemporally precise modulation of physiological ...
Xinyue Dai, Liang Chen, Wei Feng, Yu Chen   +3 more
wiley   +1 more source

Matrix Control of Solvent and Electron Flow in a Nonheme Diiron Nitrite Reductase. [PDF]

JACS Au
Chen HY, Lu YS, Cheng CC, Lo FC, Yang T, Chiang YW.   +5 more
europepmc   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Synergistic Integration of Enzyme and Microbial Platforms for Sustainable Management of Pharmaceutical Pollutants: Towards a Greener Pharmaceutical Lifecycle. [PDF]

Biology (Basel)
Sun Z, Chen P, Ge X, Zhang W, Liu H.
europepmc   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source