Results 241 to 250 of about 419,459 (324)

A mismatch in enzyme-redox partnerships underlies divergent cytochrome P450 activities between human hepatocytes and microsomes. [PDF]

Commun Biol
Bapiro TE, Martin S, Blacker TS, Wilkinson SD, Orton AL, Hariparsad N, Jones RDO, Duchen MR, Harlfinger S.   +8 more
europepmc   +1 more source

3P252 Cryogenic single molecule spectroscopy of the electron transfer cofactor in the photosynthetic reaction center(18B. Photobiology: Photosynthesis,Poster)

, 2013
Torû Kondô, Risa Mutoh, Genji Kurisu, Hirozo Oh‐oka, Satoru Fujiyoshi, Michio M. Matsushita   +5 more
openalex   +2 more sources

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Identification of Active Site Residues Involved in Substrate Binding and Cofactor Specificity in a Putrescine N-Monooxygenase

Noah S. Lyons, Robert B. Zalenski, Pablo Sobrado   +2 more
openalex   +1 more source

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

The Natural Redox Cofactor Pyrroloquinoline Quinone (PQQ) Enables Photocatalytic Radical Cyclizations. [PDF]

Angew Chem Int Ed Engl
Bahukhandi SB, Klein AS, Mustafa G, Weyh M, Walter A, Thyrhaug E, Hauer J, Storch G, Zeymer C.   +8 more
europepmc   +1 more source

Perturbation-response analysis of in silico metabolic dynamics in nonlinear regime: Hard-coded responsiveness in the cofactors and network sparsity

Yusuke Himeoka, Chikara Furusawa
openalex   +1 more source

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Quantitative decoding of coupled carbon and energy metabolism in Pseudomonas putida for lignin carbon utilization. [PDF]

Commun Biol
Zhou N, Wilkes RA, Chen X, Teitel KP, Belgrave JA, Beckham GT, Werner AZ, Yu Y, Aristilde L.   +8 more
europepmc   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source