Results 241 to 250 of about 413,042 (378)

Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies

open access: yesAnnals of Neurology, EarlyView.
Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat   +17 more
wiley   +1 more source

Regioselective C─H Functionalization by the Combination of Enzymatic and Chemocatalytic Reactions in Water

open access: yesAngewandte Chemie, EarlyView.
H3CP contributes to sustainable synthesis by integrating regioselective enzymatic halogenation, Pd‐catalyzed Heck coupling, and enzymatic hydrolysis. TPGS‐705‐M micelles enable the Pd‐catalyzed step, allowing seamless compatibility with enzymatic reactions in one vessel under aqueous conditions.
Ran Zhu   +3 more
wiley   +2 more sources

Electrocatalytic NAD(P)H regeneration for biosynthesis

open access: yesGreen Chemical Engineering
The highly efficient chemoselectivity, stereoselectivity, and regioselectivity render enzyme catalysis an ideal pathway for the synthesis of various chemicals in broad applications.
Yaoxuan Li   +8 more
doaj  

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

open access: yesThe Lancet, 1990
M. Galli   +8 more
semanticscholar   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere   +4 more
wiley   +1 more source

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

open access: yesAngewandte Chemie, EarlyView.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Jonas Fiedler   +5 more
wiley   +2 more sources

Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus. [PDF]

open access: yesNPJ Antimicrob Resist
Eke IE   +6 more
europepmc   +1 more source

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