Results 261 to 270 of about 188,158 (291)
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Molybdenum cofactor deficiency
The Journal of Pediatrics, 1993We describe a new case of molybdenum cofactor deficiency, an underrecognized inborn error of metabolism that results in neonatal seizures and neurologic abnormalities. Characteristic biochemical defects in affected individuals include hypouricemia, elevated urine sulfate (detectable by dipstick), and elevated S-sulfocysteine (detectable by anion ...
G L, Arnold +3 more
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Molybdenum cofactor deficiency
Molecular Genetics and Metabolism, 2016Molybdenum cofactor deficiency (MoCD) is a severe autosomal recessive inborn error of metabolism first described in 1978. It is characterized by a neonatal presentation of intractable seizures, feeding difficulties, severe developmental delay, microcephaly with brain atrophy and coarse facial features.
Paldeep S, Atwal, Fernando, Scaglia
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Cofactor squelching: Artifact or fact?
BioEssays, 2016Cofactor squelching is the term used to describe competition between transcription factors (TFs) for a limited amount of cofactors in a cell with the functional consequence that TFs in a given cell interfere with the activity of each other. Since cofactor squelching was proposed based primarily on reporter assays some 30 years ago, it has remained ...
Søren Fisker Schmidt +3 more
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Antioxidants & Redox Signaling, 2001
721 REDOX-ACTIVE COFACTORS, including quinones and flavins, are important components in biological systems. Together with the apoprotein, they perform complex redox chemistry, provide an important link in signal transduction, and participate in crucial electron transfer pathways, aspects that are often inefficiently carried out by the proteins ...
V M, Rotello, R P, Swenson
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721 REDOX-ACTIVE COFACTORS, including quinones and flavins, are important components in biological systems. Together with the apoprotein, they perform complex redox chemistry, provide an important link in signal transduction, and participate in crucial electron transfer pathways, aspects that are often inefficiently carried out by the proteins ...
V M, Rotello, R P, Swenson
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2001
Publisher Summary Tyrosyl radicals are found in enzymes that catalyze a wide spectrum of chemical reactions, and their functional importance is well established in class I ribonucleotide reductase (RNR), prostaglandin H synthase (PGHS), and photosystem II (PSII).
R P, Pesavento, W A, van der Donk
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Publisher Summary Tyrosyl radicals are found in enzymes that catalyze a wide spectrum of chemical reactions, and their functional importance is well established in class I ribonucleotide reductase (RNR), prostaglandin H synthase (PGHS), and photosystem II (PSII).
R P, Pesavento, W A, van der Donk
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Evaluation of cofactor responsiveness
Journal of Inherited Metabolic Disease, 1985AbstractThe response to cofactor therapy in inborn errors of metabolism may be dramatic with complete resolution of the clinical illness but more commonly the response is absent or partial. When assessing cofactor responsiveness clinical and biochemical findings as well as the natural history of the disorder must be taken into account.
J V, Leonard, P, Daish
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Science, 2019
A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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“Cofactor”-Controlled Enantioselective Catalysis
Journal of the American Chemical Society, 2011We report an achiral bisphosphine rhodium complex equipped with a binding site for the recognition of chiral anion guests. Upon binding small chiral guests--cofactors--the rhodium complex becomes chiral and can thus be used for asymmetric catalysis. Screening of a library of cofactors revealed that the best cofactors lead to hydrogenation catalysts ...
Dydio, P. +4 more
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1997
Heparin cofactor II (HCII) is a serpin that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Both of these glycosaminoglycans bind to HCII and increase the rate of inhibition of thrombin >1000-fold. This review will focus on the biochemistry of HCII and the mechanism by which glycosaminoglycans stimulate its activity.
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Heparin cofactor II (HCII) is a serpin that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Both of these glycosaminoglycans bind to HCII and increase the rate of inhibition of thrombin >1000-fold. This review will focus on the biochemistry of HCII and the mechanism by which glycosaminoglycans stimulate its activity.
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2023
An electrochemical system comprising an electrode (D) having a porous layer and plural enzymes and a cofactor (ATP) located within the pores of the porous layer, a first of said plural enzymes (E1) being operable to recycle nicotinamide cofactors (N) in response to an electrical stimulus, a second of said plural enzymes (E2) being operable to convert a
Armstrong, Fraser A. +2 more
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An electrochemical system comprising an electrode (D) having a porous layer and plural enzymes and a cofactor (ATP) located within the pores of the porous layer, a first of said plural enzymes (E1) being operable to recycle nicotinamide cofactors (N) in response to an electrical stimulus, a second of said plural enzymes (E2) being operable to convert a
Armstrong, Fraser A. +2 more
openaire +1 more source