Results 31 to 40 of about 419,459 (324)

Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]

, 2013
The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin, Danyal, Karamatullah, Dean, Dennis R., Duval, Simon, Hoffman, Brian M., Lytle, Anna K., Seefeldt, Lance C., Shaw, Sudipta   +7 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Peroxisomal Cofactor Transport [PDF]

Biomolecules, 2020
Peroxisomes are eukaryotic organelles that are essential for growth and development. They are highly metabolically active and house many biochemical reactions, including lipid metabolism and synthesis of signaling molecules. Most of these metabolic pathways are shared with other compartments, such as Endoplasmic reticulum (ER), mitochondria, and ...
Anastasija Plett, Lennart Charton, Nicole Linka   +2 more
openaire   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Nature Immunology, 2018
Multipotent progenitor cells confirm their T cell–lineage identity in the CD4–CD8– double-negative (DN) pro-T cell DN2 stages, when expression of the essential transcription factor Bcl11b begins.
H. Hosokawa, Maile Romero-Wolf, M. Yui, Jonas Ungerbäck, Maria L. G. Quiloan, M. Matsumoto, K. Nakayama, Tomoaki Tanaka, E. Rothenberg   +8 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Enzymatic regeneration of adenosine triphosphate cofactor [PDF]

, 1974
Regenerating adenosine triphosphate (ATP) from adenosine diphosphate (ADP) by enzymatic process which utilizes carbamyl phosphate as phosphoryl donor is technique used to regenerate expensive cofactors.
Marshall, D. L.
core   +1 more source

A computational framework to emulate the human perspective in flow cytometric data analysis [PDF]

, 2012
Background: In recent years, intense research efforts have focused on developing methods for automated flow cytometric data analysis. However, while designing such applications, little or no attention has been paid to the human perspective that is ...
AP Dempster, B Ellis, B Lindsay, BG Lindsay, BW Silverman, BW Silverman, C Jarque, Christopher V. Rao, D Novo, D Sarkar, DJ Marchette, DR Parks, E Choy, E Lugli, F Hahne, F Hahne, F Hahne, G Finak, G Finak, G Luta, G McLachlan, H Zare, J Li, J Trotter, JA Hartigan, JA Hartigan, JM Irish, JP Baudry, K Lo, L Herzenberg, LM Maier, MC Minnotte, MY Cheng, MY Cheng, MY Cheng, N Aghaeepour, PM Hartigan, R Scheuermann, R Tibshirani, RR Brinkman, S Pyne, S Ray, S Ray, Saumyadipta Pyne, Surajit Ray, T Lin, T Lin   +46 more
core   +5 more sources

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

Frontiers in Neuroscience, 2019
The aggregation of the human tau protein into neurofibrillary tangles is directly diagnostic of many neurodegenerative conditions termed tauopathies.
Y. Fichou, Z. Oberholtzer, H. Ngo, Chi-yuan Cheng, T. Keller, N. A. Eschmann, Songi Han   +6 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source