Results 31 to 40 of about 188,158 (291)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus

Journal of Virology
APOBEC3 proteins (A3s) play an important role in host innate immunity against viruses and DNA mutations in cancer. A3s-induced mutations in both viral and human DNA genomes vary significantly from non-lethal mutations in viruses to localized ...
Zhigang Chen, Thomas L. Eggerman, Alexander V. Bocharov, Irina N. Baranova, Tatyana G. Vishnyakova, Amy P. Patterson   +5 more
doaj   +1 more source

OPTIMIZATION OF ENZYME PARAMETERS FOR FERMENTATIVE PRODUCTION OF BIORENEWABLE FUELS AND CHEMICALS

Computational and Structural Biotechnology Journal, 2012
Microbial biocatalysts such as Escherichia coli and Saccharomyces cerevisiae have been extensively subjected to Metabolic Engineering for the fermentative production of biorenewable fuels and chemicals. This often entails the introduction of new enzymes,
Laura R. Jarboe, Ping Liu, Kumar Babu Kautharapu, Lonnie O. Ingram   +3 more
doaj   +1 more source

Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly

Open Veterinary Journal, 2023
Background: In 2015, an unprecedented epidemic of microcephaly occurred in Brazil. Preliminary observations suggested involvement of cofactors in the etiopathology of Zika virus associated microcephaly.
Massimo Giangaspero, Tamaki Okabayashi
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Targeting MYCN in Pediatric and Adult Cancers

Frontiers in Oncology, 2021
The deregulation of the MYC family of oncogenes, including c-MYC, MYCN and MYCL occurs in many types of cancers, and is frequently associated with a poor prognosis.
Zhihui Liu, Samuel S. Chen, Saki Clarke, Veronica Veschi, Carol J. Thiele   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Archaeal heme a synthase: evolutionary trajectory distinct from bacterial homologs

Frontiers in Microbiology
Hemes are iron-containing porphyrin compounds that play a crucial role in a wide array of biological processes. Heme a synthase (HAS) is a crucial enzyme that facilitates the biosynthesis of heme a, an essential heme variant that serves as a cofactor in ...
Val Karavaeva, Val Karavaeva, Marco Rampin, Jordi Zamarreño Beas, Lígia M. Saraiva, Filipa L. Sousa   +5 more
doaj   +1 more source

Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors

Frontiers in Neuroscience, 2021
Prion diseases have been described in humans and other mammals, including sheep, goats, cattle, and deer. Since mice, hamsters, and cats are susceptible to prion infection, they are often used to study the mechanisms of prion infection and conversion ...
Juliana N. Angelli, Juliana N. Angelli, Yulli M. Passos, Julyana M. A. Brito, Jerson L. Silva, Yraima Cordeiro, Tuane C. R. G. Vieira, Tuane C. R. G. Vieira   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source