Results 61 to 70 of about 418,378 (371)

OPTIMIZATION OF ENZYME PARAMETERS FOR FERMENTATIVE PRODUCTION OF BIORENEWABLE FUELS AND CHEMICALS

Computational and Structural Biotechnology Journal, 2012
Microbial biocatalysts such as Escherichia coli and Saccharomyces cerevisiae have been extensively subjected to Metabolic Engineering for the fermentative production of biorenewable fuels and chemicals. This often entails the introduction of new enzymes,
Laura R. Jarboe, Ping Liu, Kumar Babu Kautharapu, Lonnie O. Ingram   +3 more
doaj   +1 more source

Genome-Scale Mining of Acetogens of the Genus Clostridium Unveils Distinctive Traits in [FeFe]- and [NiFe]-Hydrogenase Content and Maturation

Microbiology Spectrum, 2022
Knowledge of the organizational and functional properties of hydrogen metabolism is pivotal to the construction of a framework supportive of a hydrogen-fueled low-carbon economy. Hydrogen metabolism relies on the mechanism of action of hydrogenases.
Pier Francesco Di Leonardo, Giacomo Antonicelli, Valeria Agostino, Angela Re   +3 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus

Journal of Virology
APOBEC3 proteins (A3s) play an important role in host innate immunity against viruses and DNA mutations in cancer. A3s-induced mutations in both viral and human DNA genomes vary significantly from non-lethal mutations in viruses to localized ...
Zhigang Chen, Thomas L. Eggerman, Alexander V. Bocharov, Irina N. Baranova, Tatyana G. Vishnyakova, Amy P. Patterson   +5 more
doaj   +1 more source

A Recursive Scheme of First Integrals of the Geodesic Flow of a Finsler Manifold [PDF]

, 2007
We review properties of so-called special conformal Killing tensors on a Riemannian manifold $(Q,g)$ and the way they give rise to a Poisson-Nijenhuis structure on the tangent bundle $TQ$.
Sarlet, Willy
core   +4 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase [PDF]

, 2008
YqjH is a cytoplasmic FAD-containing protein from Escherichia coli; based on homology to ViuB of Vibrio cholerae, it potentially acts as a ferri-siderophore reductase.
Andrews, Simon C., Armour, Maria, Bamford, Vicki A., Cartron, Michael, Mitchell, Sue A., Watson, Kimberly A.   +5 more
core   +2 more sources

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Nature Immunology, 2018
Multipotent progenitor cells confirm their T cell–lineage identity in the CD4–CD8– double-negative (DN) pro-T cell DN2 stages, when expression of the essential transcription factor Bcl11b begins.
H. Hosokawa, Maile Romero-Wolf, M. Yui, Jonas Ungerbäck, Maria L. G. Quiloan, M. Matsumoto, K. Nakayama, Tomoaki Tanaka, E. Rothenberg   +8 more
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

The impact of protein S and tissue factor pathway inhibitor on coagulation, assessed with thrombin generation, in women starting combined oral contraceptives

Research and Practice in Thrombosis and Haemostasis
Background: Combined oral contraceptives (COCs) are associated with an increased risk of venous thromboembolism. Several changes are induced in both coagulant and anticoagulant factors, of which the impact on protein S (PS) and tissue factor pathway ...
Jesper Strandberg, Jette Nybo, Inger Lise Gade, Søren Risom Kristensen   +3 more
doaj   +1 more source