Results 71 to 80 of about 349,815 (226)

The compositional and evolutionary logic of metabolism

, 2012
Metabolism displays striking and robust regularities in the forms of modularity and hierarchy, whose composition may be compactly described. This renders metabolic architecture comprehensible as a system, and suggests the order in which layers of that ...
Alberts B, Andreini C, Balche W E, Barker H A, Benner S A, Berge C, Braakman R, Brazelton W J, Buss L W, Collins M D, Copley S D, Dagley S, Darwin C, de Duve C, Doyle J, Eric Smith, Erwin D H, Feist A M, Fenchel T, Fisher R A, Fry I, Gerhart J, Gesteland R F, Gould S J, Gray H B, Guiral M, Haldane J B S, Kallen R G, Kauffman S, Kim J, Lengeler J W, Ljungdahl L, MacKenzie R E, Martin W, Massey L K, Metzler D E, Morowitz H J, Morowitz H J, Morowitz H J, Nelson D L, Nitscke W, Odling-Smee F J, Oparin A I, Petsko G A, Puigbo P, Ragsdale S, Ragsdale S W, Rankama K, Razin S, Redfield A C, Redfield A C, Rogier Braakman, Russell M J, Schrödinger E, Schuster P, Segré D, Shapiro R, Simon H A, Simon H A, Smith E, Srinivasan V, Srinivasan V, Sterner R W, Stryer L, Szent-Gyorgyi A, Tazuya K, Utter M F, Vogels G D, von Wettstein D, Vorholt J A, Waber L J, Wald G, Wilson E B, Wächtershäuser G, Yarus M, Yi L   +75 more
core   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research
Therapeutic DNAzyme, often activated by catalytic cofactors in its central catalytic domain, has been extensively explored for the treatment of diverse diseases, primarily through mechanisms involving free release, notably within gene therapy frameworks.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
doaj   +1 more source

Automated analysis of oxidative metabolites [PDF]

, 1974
An automated system for the study of drug metabolism is described. The system monitors the oxidative metabolites of aromatic amines and of compounds which produce formaldehyde on oxidative dealkylation.
Furner, R. L.
core   +1 more source

Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds

Advanced Science
Current attempts to transform our fossil fuel‐based society into a sustainable one involve learning from and employing the biochemistry of nature. The process of photosynthesis is exemplary for utilizing sunlight as a regenerative energy source.
Yiting She, Vera Engelbrecht, Jacek Kozuch, Ulf‐Peter Apfel, Sven T. Stripp, Anja Hemschemeier, Thomas Happe   +6 more
doaj   +1 more source

Overview on the Bacterial Iron-Riboflavin Metabolic Axis

Frontiers in Microbiology, 2018
Redox reactions are ubiquitous in biological processes. Enzymes involved in redox metabolism often use cofactors in order to facilitate electron-transfer reactions. Common redox cofactors include micronutrients such as vitamins and metals.
Ignacio Sepúlveda Cisternas, Juan C. Salazar, Víctor A. García-Angulo   +2 more
doaj   +1 more source

The First Step and the Cob(II)alamin Cofactor Inactive Particles Reactivation in the Updated Mechanism of the Methionine Synthase Process [PDF]

, 2023
Tudor Spataru
openalex   +1 more source

Formation and Function of the Rbl2p-beta-Tubulin Complex [PDF]

, 1998
The yeast protein Rbl2p suppresses the deleterious effects of excess beta-tubulin as efficiently as does alpha-tubulin. Both in vivo and in vitro, Rbl2p forms a complex with beta-tubulin that does not contain alpha-tubulin, thus defining a second pool of
Archer, Julie E., Magendantz, Margaret, Solomon, Frank, Vega, Leticia R.   +3 more
core  

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]

, 2008
The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Georg Wille, Manfred Weiss, Michael Spinka, Ralph Golbik, Steffen Kutter, Stephan Kö   +5 more
core   +1 more source

Overcoming barriers for investigating nickel-pincer nucleotide cofactor-related enzymes

mBio
The nickel-pincer nucleotide (NPN) cofactor is a modified pyridinium mononucleotide that tri-coordinates nickel and is crucial for the activity of certain racemases and epimerases. LarB, LarC, and LarE are responsible for NPN synthesis, with the cofactor
Jorge L. Nevarez, Aiko Turmo, Santhosh Gatreddi, Swati Gupta, Jian Hu, Robert P. Hausinger   +5 more
doaj   +1 more source

On cofactored verification of EdDSA signatures [PDF]

International Journal of Electronics and Telecommunications
EdDSA is a Schnorr signature scheme instantiated on top of Edwards curves, which admit fast, constant-time arithmetic, but suffer from the presence of a non-trivial cofactor, where the order of the group of points is a large prime times a small integer ...
Adrian Cinal, Oliwer Sobolewski
doaj   +1 more source