Results 101 to 110 of about 2,155 (232)

Cocrystals of Isoniazid with Polyphenols: Mechanochemical Synthesis and Molecular Structure

Crystals, 2020
Isoniazid is used as anti-tuberculosis drug which possesses functional groups capable of forming hydrogen bonds. A series of cocrystals of isoniazid (INH) with polyphenolic coformers such as catechol (CAT), orcinol (ORC), 2-methylresorcinol (MER ...
Juan Saulo González-González, Ana María Monserrat Martínez-Santiago, Francisco Javier Martínez-Martínez, María José Emparán-Legaspi, Armando Pineda-Contreras, Marcos Flores-Alamo, Héctor García-Ortega   +6 more
doaj   +1 more source

Solid solution quantification from full powder X‐ray diffraction profile: novel application of multivariate calibration

Journal of Applied Crystallography, Volume 58, Issue 5, Page 1700-1711, October 2025.
A new application of quantitative chemometric models (principal component regression and partial least‐squares regression) to powder X‐ray diffraction data is tested. The approach allows evaluation of the relative composition of solid solutions via the characteristic profile shift.
Laura Macchietti, Nicholas Kassouf, Giovanni Valenti, Dora Melucci, Fabrizia Grepioni   +4 more
wiley   +1 more source

Structural, Hirshfeld surface and theoretical analysis of two conformational polymorphs of N,N′-bis(pyridin-3-ylmethyl)oxalamide [PDF]

, 2016
The common feature of two conformational polymorphs of N,N′-bis(pyridin-3-ylmethyl)oxalamide is their crystallisation in the monoclinic space group P21/c with Z=4.
Arman, Hadi D., Jotani, Mukesh M., Miller, Tyler, Poplaukhin, Pavel, Sousa Madureira, Lucas, Tiekink, Edward R. T. *, Zukerman-Schpector, Julio   +6 more
core   +1 more source

Growing Interest in Pharmaceutical Cocrystals: A Comprehensive Review of Applications and Trends

ChemistrySelect, Volume 10, Issue 30, August 8, 2025.
Cocrystallization of an Active Pharmaceutical Ingredient (API) with a suitable coformer enables the development of multicomponent crystalline systems through green, cost‐effective methods. These cocrystals can enhance key physicochemical and biopharmaceutical properties. Abstract The synthesis of cocrystals stands as a promising and compelling strategy
Sandra Barbosa Neder Agostini, Bruno Arantes Borges, Magali Benjamim de Araújo, Rudy Bonfilio   +3 more
wiley   +1 more source

Thermal and in situ x-ray diffraction analysis of a dimorphic co-crystal 1:1 caffeine-glutaric acid [PDF]

, 2015
YesSpurred by the enormous interest in co-crystals from the pharmaceutical industry, many novel co-crystals of active pharmaceutical ingredients have been discovered in recent years and this has in turn led to an increasing number of reports on ...
Bernstein J., Brittain H. G., Byrn S. R., Grace Lau, Hilfiker R., Martin Schreyer, Peterson M. L., Pui Shan Chow, Reginald B. H. Tan, Venu R. Vangala   +9 more
core   +1 more source

Bio-Purines as Co-Formers in Resveratrol Amorphous Systems

Crystals
In the organic biomineralization of guanine (GUA), amorphous GUA is utilized to enhance its solubility, facilitating its transport for the formation of biominerals, and GUA nanocrystals are employed to protect tissues from ultraviolet damage.
Yuhang Liu, Ziqing Wu, Fenghua Chen, Yongming Liu, Rongrong Xue   +4 more
doaj   +1 more source

Vapor‐Assisted Mechanochemical Synthesis of Enzyme and Hydrogen‐Bonded Organic Framework Biocomposites

Small, Volume 21, Issue 33, August 21, 2025.
It is demonstrated that a combination of mechanochemistry and accelerated aging can be used to synthesize Hydrogen‐bonded Organic Framework (HOF) biocomposites. The vapor‐induced growth enhances enzyme loading, ensures a more homogeneous enzyme distribution, and improves protective properties due to distinct growth mechanisms and kinetics.
Michael R. Hafner, Natalija Pantalon Juraj, Kate Flint, Helmar Wiltsche, Heimo Wolinski, Heinz Amenitsch, Christian J. Doonan, Krunoslav Užarević, Francesco Carraro   +8 more
wiley   +1 more source

Fine‐Tuning the Motion of Tetrafluoro‐1,4‐Benzoquinone within Charge‐Transfer Cocrystals Through Variation of the Donor: An Entropic and Enthalpic Point of View

Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.
Five CT cocrystals using TFBQ and fused, polycyclic donors derived from fluorene are synthesized. The π‐stacking in all cocrystals provides a platform for the displaying of in‐plane molecular motions of TFBQ, which is by supramolecular interactions.
Armando Navarro‐Huerta, Martha E. García‐Aguilera, Jan Blahut, Erika Bartůňková, Rubén A. Toscano, Mario Rodríguez, Martin Dračínský, Braulio Rodríguez‐Molina   +7 more
wiley   +1 more source

Multicomponent crystals: Solubility enhancement of simvastatin using arginine and glycine coformers [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Simvastatin can be modified by the formation of multicomponent crystals to increase its solubility. Aims: To compare the solubility of multicomponent simvastatin crystals to pure simvastatin. Methods: The in silico study of simvastatin and
Iyan Sopyan, Karyn Elizabeth, Sandra Megantara, Silmy Kaffah   +3 more
doaj   +1 more source

Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution

Pharmaceutics, 2017
In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution.
Hao Zhang, Ying Zhu, Ning Qiao, Yang Chen, Linghuan Gao   +4 more
doaj   +1 more source