Results 81 to 90 of about 1,361 (189)

Origin of phase relative stability and phase transformation in an S‐ibuprofen–nicotinamide cocrystal

Acta Crystallographica Section C, Volume 81, Issue 11, Page 658-665, November 2025.
The crystal structure of the metastable form of S‐ibuprofen–nicotinamide cocrystals was solved from powder X‐ray diffraction data and explains the main mechanisms responsible for the relative stability of the two forms of the cocrystals. This also made it possible to explain the transition mechanism between the two forms with temperature.The crystal ...
Mathieu Guerain, Hubert Chevreau, Erik Elkaim, Yannick Guinet, Laurent Paccou, Florence Danède, Alain Hedoux, Frederic Affouard   +7 more
wiley   +1 more source

Integrated Selection of Coformers, Solvents, and Operating Conditions for Optimal Process and Product Performance of Pharmaceutical Cocrystals

, 2023
The poor aqueous solubility of many modern active pharmaceutical ingredients (APIs) can severely limit bioavailability. Cocrystals are emerging as a promising means of overcoming this limitation.
Jiatao Li, Richard Lakerveld (1784755), Richard Lakerveld, Jiatao Li (10033795), Nethrue Pramuditha Mendis (13183490), Nethrue Pramuditha Mendis   +5 more
core   +2 more sources

Solid solution quantification from full powder X‐ray diffraction profile: novel application of multivariate calibration

Journal of Applied Crystallography, Volume 58, Issue 5, Page 1700-1711, October 2025.
A new application of quantitative chemometric models (principal component regression and partial least‐squares regression) to powder X‐ray diffraction data is tested. The approach allows evaluation of the relative composition of solid solutions via the characteristic profile shift.
Laura Macchietti, Nicholas Kassouf, Giovanni Valenti, Dora Melucci, Fabrizia Grepioni   +4 more
wiley   +1 more source

Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution

Pharmaceutics, 2017
In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution.
Hao Zhang, Ying Zhu, Ning Qiao, Yang Chen, Linghuan Gao   +4 more
doaj   +1 more source

Growing Interest in Pharmaceutical Cocrystals: A Comprehensive Review of Applications and Trends

ChemistrySelect, Volume 10, Issue 30, August 8, 2025.
Cocrystallization of an Active Pharmaceutical Ingredient (API) with a suitable coformer enables the development of multicomponent crystalline systems through green, cost‐effective methods. These cocrystals can enhance key physicochemical and biopharmaceutical properties. Abstract The synthesis of cocrystals stands as a promising and compelling strategy
Sandra Barbosa Neder Agostini, Bruno Arantes Borges, Magali Benjamim de Araújo, Rudy Bonfilio   +3 more
wiley   +1 more source

Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization

Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs) through cocrystallization is an important part of drug product development.
Constantinos C. Pantelides (1356237), Isaac J. Sugden (1356243), Doris E. Braun (1274841), David H. Bowskill (12876145), Claire S. Adjiman (1356249)   +4 more
core   +1 more source

Vapor‐Assisted Mechanochemical Synthesis of Enzyme and Hydrogen‐Bonded Organic Framework Biocomposites

Small, Volume 21, Issue 33, August 21, 2025.
It is demonstrated that a combination of mechanochemistry and accelerated aging can be used to synthesize Hydrogen‐bonded Organic Framework (HOF) biocomposites. The vapor‐induced growth enhances enzyme loading, ensures a more homogeneous enzyme distribution, and improves protective properties due to distinct growth mechanisms and kinetics.
Michael R. Hafner, Natalija Pantalon Juraj, Kate Flint, Helmar Wiltsche, Heimo Wolinski, Heinz Amenitsch, Christian J. Doonan, Krunoslav Užarević, Francesco Carraro   +8 more
wiley   +1 more source

Fine‐Tuning the Motion of Tetrafluoro‐1,4‐Benzoquinone within Charge‐Transfer Cocrystals Through Variation of the Donor: An Entropic and Enthalpic Point of View

Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.
Five CT cocrystals using TFBQ and fused, polycyclic donors derived from fluorene are synthesized. The π‐stacking in all cocrystals provides a platform for the displaying of in‐plane molecular motions of TFBQ, which is by supramolecular interactions.
Armando Navarro‐Huerta, Martha E. García‐Aguilera, Jan Blahut, Erika Bartůňková, Rubén A. Toscano, Mario Rodríguez, Martin Dračínský, Braulio Rodríguez‐Molina   +7 more
wiley   +1 more source

Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-Ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis

Molecules, 2019
Four novel xanthohumol (XN) cocrystals with pharmaceutically acceptable coformers, such as nicotinamide (NIC), glutarimide (GA), acetamide (AC), and caffeine (CF) in the 1:1 stoichiometry were obtained by the slow evaporation solution growth technique ...
Iwona Budziak, Marta Arczewska, Daniel M. Kamiński   +2 more
doaj   +1 more source

The curious case of proton migration under pressure in the malonic acid and 4,4′-bipyridine cocrystal

IUCrJ
In the search for new active pharmaceutical ingredients, the precise control of the chemistry of cocrystals becomes essential. One crucial step within this chemistry is proton migration between cocrystal coformers to form a salt, usually anticipated by ...
Ewa Patyk-Kaźmierczak, Fernando Izquierdo-Ruiz, Alvaro Lobato, Michał Kaźmierczak, Ida Moszczyńska, Anna Olejniczak, J. Manuel Recio   +6 more
doaj   +1 more source