Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review [PDF]
Heliyon, 2022 Pharmaceutical cocrystals, which contain at least one active pharmaceutical ingredient (API), are still an attention-grabbing field for researchers. Two or more discrete molecules unite together by non-covalent bonds, e.g., hydrogen, Van der Waals, and π⋯
M Bashimam
exaly +6 more sources
Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals [PDF]
Pharmaceutics, 2021 Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc.
Tom Leyssens +2 more
exaly +5 more sources
Pharmaceutical Cocrystals—A Review [PDF]
Proceedings, 2021 The design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and ...
Sheetal S. Buddhadev, Kevin C. Garala
doaj +2 more sources
Polymorphism of Carbamazepine Pharmaceutical Cocrystal: Structural Analysis and Solubility Performance [PDF]
Pharmaceutics, 2023 Polymorphism is a common phenomenon among single- and multicomponent molecular crystals that has a significant impact on the contemporary drug development process. A new polymorphic form of the drug carbamazepine (CBZ) cocrystal with methylparaben (MePRB)
Artem O. Surov +6 more
doaj +2 more sources
Pharmaceutical Cocrystal Formation of Pyrazinamide with 3-Hydroxybenzoic Acid: A Terahertz and Raman Vibrational Spectroscopies Study [PDF]
Molecules, 2019 Vibrational modes of pyrazinamide (PZA), 3-hydroxybenzoic acid (3-hBA), and their cocrystal were characterized using terahertz time-domain (THz-TDS) and Raman vibrational spectroscopic techniques.
Qiqi Wang, Jiadan Xue, Zhi Hong, Yong Du
doaj +2 more sources
Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal
Pharmaceutics, 2020 The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field.
Maria JOSÉ Santos-Martínez +2 more
exaly +3 more sources
Pharmaceutical Cocrystal Development of TAK-020 with Enhanced Oral Absorption
Crystals, 2020 The objective of this study was to improve the solubility of poorly water-soluble drugs by pharmaceutical cocrystal engineering techniques and select the best pharmaceutical forms with high solubility and solubilized formulations for progress from the ...
Miyuki Hohokabe, Yukihiro Ikeda
exaly +3 more sources
Enhancing the Solubility of Indomethacin: A Breakthrough with Cocrystal Formation [PDF]
PharmaceuticalsBackground/objectives: Pharmaceutical cocrystals have emerged as a promising strategy to enhance the solubility and bioavailability of poorly water-soluble drugs.
Hugo Pardo +3 more
doaj +2 more sources
Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade +3 more
doaj +2 more sources
Structure and intermolecular interactions of the rare amide-pyridine synthon: a cocrystal of nicotinamide and 2-chloro-3-hydroxypyridine. [PDF]
Acta Crystallogr C Struct ChemConsidering its low occurrence in the Cambridge Structural Database, is the amide–pyridyl synthon easy to form, and what structural factors affects its interaction energy and its subsequent formation?Nicotinamide (Nico) and derivatives of pyridine are important materials in both the pharmaceutical and agrochemical industries.
Akerele O, Lemmerer A.
europepmc +2 more sources