Results 11 to 20 of about 2,679 (172)

Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment [PDF]

International Journal of Pharmaceutics: X
Emodin (EMO) shows therapeutic promise for ulcerative colitis (UC), yet its clinical utility is hampered by low bioavailability. To rationally overcome this limitation, this study employed cocrystal engineering, strategically selecting ...
Meiru Liu, Yinru Jiang, Penghui Yuan, Shuang Li, Baoxi Zhang, Xia Zhou, Bin Su, Yifei Xie, Dezhi Yang, Linglei Kong, Li Zhang, Yang Lv, Guanhua Du   +12 more
doaj   +2 more sources

Salt Cocrystallization—A Method to Improve Solubility and Bioavailability of Dihydromyricetin [PDF]

Pharmaceutics
Objectives: This study aimed to find salts with similar pharmacological effects designed as cocrystals to improve the aqueous solubility and bioavailability of dihydromyricetin (DMY).
Jingping Li, Xinke Chen, Yanan Liu, Caiwu Jiang   +3 more
doaj   +2 more sources

Terahertz and Raman Spectroscopic Investigation of Monohydrate Cocrystal of Antitubercular Isoniazid with Protocatechuic Acid

Pharmaceutics, 2021
Pharmaceutical cocrystal provides an alternative modification strategy for the formulation development of drugs owning to their potential ability to improve the physicochemical properties of active pharmaceutical ingredients (APIs) efficiently by ...
Yanhua Bo, Jiyuan Fang, Ziming Zhang, Jiadan Xue, Jianjun Liu, Zhi Hong, Yong Du   +6 more
doaj   +1 more source

Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal

Brazilian Journal of Pharmaceutical Sciences, 2023
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF ...
Xintong Yang, Yang Chen, Ning Qiao
doaj   +1 more source

New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties

Pharmaceutics, 2023
This study describes the preparation, characterization, and influence of the enantiopure vs. racemic coformer on the physico-chemical properties of a pharmaceutical cocrystal.
Panpan Ma, Balthazar Toussaint, Enrica Angela Roberti, Noémie Scornet, Axel Santos Silva, Luis Castillo Henríquez, Monique Cadasse, Philippe Négrier, Stéphane Massip, Hanh Dufat, Karim Hammad, Cecilia Baraldi, Maria Cristina Gamberini, Cyrille Richard, Stéphane Veesler, Philippe Espeau, Tu Lee, Yohann Corvis   +17 more
doaj   +1 more source

Mechanochemical Synthesis of the Catechol-Theophylline Cocrystal: Spectroscopic Characterization and Molecular Structure

Applied Sciences, 2021
Pharmaceutical cocrystallization offers the possibility to modify the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients.
Juan Saulo González-González, Raquel Jiménez-López, David Ortegón-Reyna, Gabino Gonzalez-Carrillo, Francisco Javier Martínez-Martínez   +4 more
doaj   +1 more source

Molecular Structure, Spectral Investigations, Hydrogen Bonding Interactions and Reactivity-Property Relationship of Caffeine-Citric Acid Cocrystal by Experimental and DFT Approach

Frontiers in Chemistry, 2021
The pharmaceutical cocrystal of caffeine-citric acid (CAF-CA, Form II) has been studied to explore the presence of hydrogen bonding interactions and structure-reactivity-property relationship between the two constituents CAF and Citric acid.
Priya Verma, Anubha Srivastava, Karnica Srivastava, Poonam Tandon, Manishkumar R. Shimpi, Manishkumar R. Shimpi   +5 more
doaj   +1 more source

Competitive cocrystallization and its application in the separation of flavonoids

IUCrJ, 2021
Recently, cocrystallization has been widely employed to tailor physicochemical properties of drugs in the pharmaceutical field. In this study, cocrystallization was applied to separate natural compounds with similar structures.
Yanming Xia, Yuanfeng Wei, Hui Chen, Shuai Qian, Jianjun Zhang, Yuan Gao   +5 more
doaj   +1 more source

Pharmaceutical Cocrystals and Their Physicochemical Properties [PDF]

Crystal Growth & Design, 2009
This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.
Schultheiss, Nate, Newman, Ann
openaire   +2 more sources

Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

Pharmaceutics, 2021
Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj   +1 more source