Results 31 to 40 of about 1,115 (165)

Enhancing Dissolution Rate and Antibacterial Efficiency of Azithromycin through Drug-Drug Cocrystals with Paracetamol

Antibiotics, 2021
Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile.
Noor Ul Islam, Ezzat Khan, Muhammad Naveed Umar, Attaullah Shah, Muhammad Zahoor, Riaz Ullah, Ahmed Bari   +6 more
doaj   +1 more source

Optimized solubility and bioavailability of genistein based on cocrystal engineering

Natural Products and Bioprospecting, 2023
With various potential health-promoting bioactivities, genistein has great prospects in treatment of a series of complex diseases and metabolic syndromes such as cancer, diabetes, cardiovascular diseases, menopausal symptoms and so on.
Zhipeng Wang, Qi Li, Qi An, Lixiang Gong, Shiying Yang, Baoxi Zhang, Bin Su, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du   +10 more
doaj   +1 more source

Melting Diagrams of Adefovir Dipivoxil and Dicarboxylic Acids: An Approach to Assess Cocrystal Compositions

Crystals, 2019
Pharmaceutical cocrystallization is a useful method to regulate the physical properties of active pharmaceutical ingredients (APIs). Since the cocrystals may form in various API/coformer ratios, identification of the cocrystal composition is the critical
Hyunseon An, Insil Choi, Il Won Kim
doaj   +1 more source

A method for improving the properties of famotidine

Heliyon, 2023
According to crystal engineering, the pharmaceutical intermediate m-nitrobenzoic acid (MNBA), which contains a carboxylic acid group, was selected as a coformer (CCF) for drug cocrystallization with famotidine (FMT), and a new stable FMT salt cocrystal ...
Yongfeng Zhao, Ying Fan, Yan Zhang, Hong Xu, Min Li, Yunjie Zhu, Zhao Yang   +6 more
doaj   +1 more source

Pharmaceutical Cocrystals: An Emerging Approach to Modulate Physicochemical Properties of Active Pharmaceutical Ingredients

, 2023
Most of the Active Pharmaceutical Ingredients (APIs) are typically formulated and administered to patients in oral solid dosage forms due to ease of administration, patient compliance and cost effectiveness.
Jadhav, Amrapali B., Amrapali B. Jadhav, Suraj Ankush Tupe, Shital Prabhakar Khandagale, Khandagale, Shital Prabhakar, Tupe, Suraj Ankush   +5 more
core   +1 more source

Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape

Pharmaceutics, 2021
Any time the pharmaceutical industry develops a new drug, potential polymorphic events must be thoroughly described, because in a crystalline pharmaceutical solid, different arrangements of the same active pharmaceutical ingredient can yield to very ...
Francisco Javier Acebedo-Martínez, Carolina Alarcón-Payer, Antonio Frontera, Rafael Barbas, Rafel Prohens, Milena Di Crisci, Alicia Domínguez-Martín, Jaime Gómez-Morales, Duane Choquesillo-Lazarte   +8 more
doaj   +1 more source

Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Enhancing Cocrystal Yield [PDF]

, 2017
Pharmaceutical cocrystals have attracted increasing attention over the past decade as an alternative way to modify the physicochemical properties and hence improve the bioavailability of a drug, without sacrificing thermodynamic stability.
David S. Jones, Colette Lagan, Gavin P. Andrews, Yiwei Tian, Andrews, Gavin, Tao Yu, Jones, David, Shu Li, Li, Shu, Tian, Yiwei; id_orcid, Yu, Tao, Lagan, Colette   +11 more
core   +1 more source

Cocrystals of Praziquantel with Phenolic Acids: Discovery, Characterization, and Evaluation

Molecules, 2022
Solvent-assisted grinding (SAG) and solution slow evaporation (SSE) methods are generally used for the preparation of cocrystals. However, even by using the same solvent, active pharmaceutical ingredient (API), and cocrystal coformer (CCF), the ...
Shiying Yang, Qiwen Liu, Weiwen Ji, Qi An, Junke Song, Cheng Xing, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du   +9 more
doaj   +1 more source

Indomethacin-saccharin cocrystal : design, synthesis and preliminary pharmaceutical characterization

, 2008
Purpose. To design and prepare cocrystals of indomethacin using crystal engineering approaches, with the ultimate objective of improving the physical properties of indomethacin, especially solubility and dissolution rate. Materials and Methods.
Boström, Dan,, Basavoju, Srinivas, Velaga, Sitaram P.,, Velaga, Sitaram P., Basavoju, Srinivas,   +4 more
core   +1 more source

RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies

Heliyon
In this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (−)-ibuprofen (R(−)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which
Yaqi Jing, Qiuhui Zhao, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du   +7 more
doaj   +1 more source