Solution Cocrystallization: A Scalable Approach for Cocrystal Production
Crystals, 2021 With an increasing interest in cocrystals due to various advantages, demand for large-scale cocrystallization techniques is rising. Solution cocrystallization is a solvent-based approach that utilizes several single-component crystallization concepts as ...
Nitin Pawar +2 more
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Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications [PDF]
MoleculesFlavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being, and
Urszula Izabela Maciołek +4 more
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Competitive cocrystallization and its application in the separation of flavonoids [PDF]
IUCrJ, 2021 Recently, cocrystallization has been widely employed to tailor physicochemical properties of drugs in the pharmaceutical field. In this study, cocrystallization was applied to separate natural compounds with similar structures.
Yanming Xia +5 more
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Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
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Cocrystal Engineering of Conjugated Polymer Blends via External Electric Field for Enhanced Charge Transport [PDF]
Advanced ScienceCocrystal engineering that combines different components into cocrystals renders the newly formed materials with innovative and multifunctional properties. However, this strategy is rather limitedly explored in conjugated polymer blends.
Yanan Guo, Hao Zheng, Juan Peng
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Application of cosolvency and cocrystallization approach to enhance acyclovir solubility [PDF]
BMC ChemistryAcyclovir (ACY) is a commonly used antiviral drug with limited aqueous solubility and poor permeability. It is administered via oral and intravenous routes.
Elham Azad Khiabani +2 more
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Formulation Strategies to Enhance the Solubility of Poorly Water-Soluble Drugs and Phytochemicals: Current Advances and Challenges [PDF]
PharmaceuticsThe low water solubility of numerous drug candidates and phytochemicals continues to pose a significant challenge in pharmaceutical development, greatly limiting their bioavailability and therapeutic performance.
Shery Jacob, Hiral Shah, Anroop B. Nair
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Antibiotics, 2021 Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile.
Noor Ul Islam +6 more
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Pharmaceutics, 2023 The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antimetabolite that has been widely used for its antineoplastic properties. Cocrystals of 5-fluorouracil (5-FU) with five different Schiff bases (benzylidene-urea
Farhat Jubeen +6 more
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Tuning the Pharmacokinetic Performance of Quercetin by Cocrystallization
Crystal Growth & Design, 2023 Quercetin (QUE) is a widely studied nutraceutical with a number of potential therapeutic properties. Although QUE is abundant in the plant kingdom, its poor solubility (≤20 μg/mL) and poor oral bioavailability have impeded its potential utility and clinical development. In this context, cocrystallization has emerged as a useful method for improving the
Molly M. Haskins +9 more
openaire +3 more sources