Results 41 to 50 of about 6,443 (221)

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Pharmaceutics, 2018
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran, Sameer Vishvanath Dalvi   +1 more
doaj   +1 more source

Improving the solubility of dexlansoprazole by cocrystallization with isonicotinamide

European Journal of Pharmaceutical Sciences, 2016
Cocrystallization of an active pharmaceutical ingredient (API) with a cocrystal former (co-former) is widely used to tailor the physicochemical properties of parent APIs. For proton-pump inhibitors (PPIs), the isolation of cocrystals has not been widely investigated.
Jianhui Li, Lianyan Wang, Yue Qi Ye, Xue Fu, Qinghua Ren, Hailu Zhang, Zongwu Deng   +6 more
openaire   +2 more sources

Comments on "Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization" [PDF]

Advanced Pharmaceutical Bulletin, 2020
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Shahram Emami, Ali Shayanfar
openaire   +3 more sources

Preparation and Characterization of Highly Water Soluble Curcumin – Dextrose Cocrystal [PDF]

Journal of Pure and Applied Chemistry Research, 2018
Curcumin is a natural food colorant isolated from rhizomes of turmeric (Curcuma longa). Despite its many favorable properties, curcumin is practically insoluble in water and relatively unstable, thus limiting its application.
Katherine Kho, Denny Nugroho, Asaf Kleopas Sugih   +2 more
doaj   +1 more source

Pharmaceutical cocrystal and their role in improving solid state properties of active pharmaceutical ingredients

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical properties without affecting their ...
Ameera A Radhi, Iman S Jaafar, Noor S Jaafar, Sarah M Faisal   +3 more
doaj   +1 more source

Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents

, 2015
Carbon dioxide has been extensively used as a green solvent medium for the crystallization of active pharmaceutical ingredients (APIs) by replacing harmful organic solvents.
Luis Padrela (1576003), Edmundo Gomes de Azevedo (1575997), João Tiago (1576000), Henrique A. Matos (1576009), Miguel A. Rodrigues (1576006), Sitaram P. Velaga (1296816)   +5 more
core   +2 more sources

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

Frontiers in Pharmacology
To overcome the poor solubility, permeability, and bioavailability of the plant isoflavone daidzein (DAI), a novel salt of DAI with anhydrous piperazine (PIP) was obtained based on cocrystallization strategy.
Jiacheng Meng, Chenxu Qiu, Chenyue Lu, Xin He, Xinghua Zhao   +4 more
doaj   +1 more source

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals

Molecules, 2023
Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including ...
Jia Xu, Qin Shi, Yanan Wang, Yong Wang, Junbo Xin, Jin Cheng, Fang Li   +6 more
doaj   +1 more source

Cocrystallization of Etodolac: Prediction of Cocrystallization, Synthesis, Solid State Characterization And In Vitro Drug Release

Marmara Pharmaceutical Journal, 2016
Bu arastirma kapsaminda, etodolak ko-kristallerinin sentezi  ve farkli koformerlerin yapilarinin aydinlatilmasi ile Hansen  cozunurluk paratmetrelerinin tayini calisilmistir. Etodolak’in  cozunurlugunun arttirilmasi ve dissolusyon ozelliginin  iyilestirilmesi amaciyla hazirlanan etodolak ko-kristallerinin  farkli koformerleri izlenmistir.
Dipak D Gadade, Sanjay S Pekamwar, Swaroop R Lahoti, Santosh D Patni, Mahesh C Sarode   +4 more
openaire   +2 more sources

Cocrystallization of Nutraceuticals

, 2016
Cocrystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of compounds used as active pharmaceutical ingredients (APIs), complementing more traditional methods such as salt formation.
Anita R. Maguire (1444246), Simon E. Lawrence (1444243), Abhijeet S. Sinha (1678756)   +2 more
core   +1 more source