Results 61 to 70 of about 6,443 (221)
Controlling Dichroism of Molecular Crystals by Cocrystallization
, 2016 A combined crystallographic and optical properties study offers a simple model for the dichroic behavior of crystalline azobenzene chromophores, leading to a cocrystallization strategy to manipulate their solid-state arrangement and, therewith, dichroic ...
Christopher J. Barrett (1410904) +2 more
core +2 more sources
Future Journal of Pharmaceutical Sciences, 2020 Background The cocrystallization process in pharmaceuticals has gained widespread attention as a recent method of modifying physicochemical properties without altering the pharmacological characteristics of drugs.
Braham Dutt +2 more
doaj +1 more source
Application and Comparison of Cocrystallization Techniques on Trospium Chloride Cocrystals
, 2016 To identify as many solid forms of active pharmaceutical ingredient (API) as possible and to monitor their cocrystallization potential, synthetic methods are needed.
Jana Cibulková (1797031) +5 more
core +1 more source
Molecules, 2021 Cocrystallization is an important route to tuning the solubility in drugs development, including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol (RSV) and kaempferol (KAE), ARI-RSV, ARI2-RSV1·MeOH, ARI-KAE, ARI-KAE·EtOH ...
Wenwen Liu +6 more
doaj +1 more source
Cocrystallization as a tool to stabilize liquid active ingredients
, 2021 Cocrystallization is an extensively used method in Crystal Engineering for tuning the properties of target compounds by pairing them with ad-hoc selected molecular partners (i.e. coformers) in a stoichiometric ratio within the same crystal structure. The
Bacchi A., Mazzeo P. P.
core +1 more source
Next Generation Hosts for Protein Recognition, Assembly and More
Chemistry – A European Journal, EarlyView.The original design of synthetic receptors for proteins was based on macrocycles with a hydrophobic core and a polar/charged periphery. This design, geared towards protein recognition, facilitates receptor self‐assembly. Macrocycle oligomerization, in turn, contributes to protein assembly as evidenced in many cocrystal structures.
Peter B. Crowley
wiley +1 more source
The Role of Iron‐Hyponitrite Intermediates in Biology and Insights From Synthetic Model Complexes
Chemistry – A European Journal, EarlyView.Despite the difference in active site architecture, NO reduction by different NOR enzymes is expected to be linked by a common intermediate: hyponitrite (N2O22−). However, experimentally, very little is known about the coordination chemistry of iron with hyponitrite and the expected Fe‐hyponitrite intermediates.
Michael O. Lengel, Nicolai Lehnert
wiley +1 more source
Chemistry – A European Journal, EarlyView.Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr +7 more
wiley +1 more source
Redox‐Active Bisphosphines Based on a W(II)‐Propargyl Complex Backbone
European Journal of Inorganic Chemistry, EarlyView.Three bisphosphine ligands based on tungsten(II) propargyl‐type alkyne complexes were synthesized and characterized. The methanolate derivative was used as a metalla‐ligand for the preparation of a binuclear bisphosphine‐κ2‐PdCl2 complex. In both cases, IR spectroelectrochemistry (IR‐SEC) measurements revealed a successive process following oxidation ...
Friederike M. Hamann +7 more
wiley +1 more source
In silico screening of dicarboxylic acids for cocrystallization with phenylpiperazine derivatives based on both cocrystallization propensity and solubility advantage [PDF]
Journal of Molecular Modeling, 2017 In silico screening was performed to search for binary solids in which a phenylpiperazine-derivative drug was cocrystallized with a dicarboxylic acid. The phenylpiperazine derivative could be any of 61 such drugs, while the dicarboxylic acid could be any of nine such acids.
openaire +2 more sources