Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
AggregateAggregation‐induced emission (AIE) and thermally activated delayed fluorescence (TADF) are two optoelectronic properties with great potential for applications.
Wei‐Yi Liang +6 more
doaj +1 more source
Electrospray technique for cocrystallization of phytomolecules
Journal of King Saud University - Science, 2018 Abstract Poor aqueous solubility of most of the phytomolecules has restricted their vital biological use. Cocrystal approach can be one of the remedies for the problem. The present work was carried out with an objective to screen the potential of electrospray technique towards cocrystallization of quercetin (QUE). QUE was cocrystallized with caffeine
Sharvil Patil +2 more
openaire +1 more source
Cocrystallization of Energetic Materials. [PDF]
, 2013 Here cocrystallization, the formation of crystals containing two or more neutral molecular components in a defined ratio within a crystal lattice, is explored as a means to alter and improve the properties of energetic materials, including explosives ...
Landenberger, Kira Beth
core
Cocrystallization approach: Dissolution rate enhancement of carbamazepine with various coformers and virtual screening tools [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cocrystallization is a promising solid-state modification used to enhance the dissolution rate and solubility of poorly water-soluble drugs, such as carbamazepine.
Taofik Rusdiana +3 more
doaj +1 more source
Cocrystallization and Copolymerization of Diacetylenes: Some Novel Observations [PDF]
Polymer Journal, 1981 The cocrystallization and copolymerization of two pairs of diacetylenes R–C≡C–C≡C–R, (1) 1 BU [R=–CH2OCONHC4H9] and 1 EU [R=–CH2OCONHC2H5], and (2) 2A [R=–(CH2)2OH] and 3A [R=(CH2)3OH] was studied by differential scanning calorimetry and reflectance spectroscopy. Several novel features were observed.
Miller, G. G., Patel, G. N.
openaire +1 more source
Constructing Anti-Glioma Drug Combination with Optimized Properties through Cocrystallization
, 2018 Cocrystallization of two anti-glioma agents, Temozolomide (TMZ) and baicalein (BAI), resulted in a cocrystal presenting superior stability for unstable TMZ as well as optimized dissolution and pharmacokinetics for TMZ and BAI. Cocrystallization can be an
Tong-Bu Lu (1516030) +4 more
core +1 more source
Improving Biopharmaceutical Properties of Vinpocetine Through Cocrystallization [PDF]
Journal of Pharmaceutical Sciences, 2016 Vinpocetine is a poorly water soluble weakly basic drug (pKa = 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improved pharmacokinetic properties is highly desirable.
GOLOB, SAMUEL +7 more
openaire +4 more sources
Cocrystallization Behavior in Binary Blend of Crystalline−Amorphous Diblock Copolymers
, 2016 Cocrystallization Behavior in Binary Blend of Crystalline−Amorphous Diblock ...
Bhanu Nandan (2306602) +4 more
core +1 more source
Interaction Map Driven Cocrystallization of Ambrisentan: Structural and Biopharmaceutical Evaluation [PDF]
, 2020 The present work deals with the development of cocrystal of ambrisentan (AMT) to improve its biopharmaceutical profile. Full interaction maps (FIM) of AMT were explored to find out the potential sites for hydrogen bonding and prediction of supramolecular
Haneef, Jamshed +2 more
core +1 more source