Results 51 to 60 of about 4,408 (188)

Cocrystallization and Copolymerization of Diacetylenes: Some Novel Observations [PDF]

Polymer Journal, 1981
The cocrystallization and copolymerization of two pairs of diacetylenes R–C≡C–C≡C–R, (1) 1 BU [R=–CH2OCONHC4H9] and 1 EU [R=–CH2OCONHC2H5], and (2) 2A [R=–(CH2)2OH] and 3A [R=(CH2)3OH] was studied by differential scanning calorimetry and reflectance spectroscopy. Several novel features were observed.
Miller, G. G., Patel, G. N.
openaire   +1 more source

New Cocrystals of Antipsychotic Drug Aripiprazole: Decreasing the Dissolution through Cocrystallization

Molecules, 2021
Cocrystallization is an important route to tuning the solubility in drugs development, including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol (RSV) and kaempferol (KAE), ARI-RSV, ARI2-RSV1·MeOH, ARI-KAE, ARI-KAE·EtOH ...
Wenwen Liu, Ru Ma, Feifei Liang, Chenxin Duan, Guisen Zhang, Yin Chen, Chao Hao   +6 more
doaj   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, EarlyView.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

Improving Biopharmaceutical Properties of Vinpocetine Through Cocrystallization [PDF]

Journal of Pharmaceutical Sciences, 2016
Vinpocetine is a poorly water soluble weakly basic drug (pKa = 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improved pharmacokinetic properties is highly desirable.
GOLOB, SAMUEL, Perry, Miranda, Lusi, Matteo, Chierotti, Michele R., GRABNAR, IZTOK, LASSIANI, LUCIA, VOINOVICH, DARIO, Zaworotko, Michael J.   +7 more
openaire   +4 more sources

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider, Claudia Hanko, Konrad Büssow, Stefan Schmelz, Wulf Blankenfeldt   +4 more
wiley   +1 more source

Circularly polarized luminescence induced by nonporous metal–organic frameworks and their photo-curable 3D printing application

Nano Research
Porous architectures are generally important for chiral metal–organic frameworks (MOFs) to fulfill chiroptical properties of guests, while induced chirality of guest molecules by nonporous chiral MOFs remains rare.
Chong Zhang, Jun-Nan Bu, Pei-Pei Ge, Shuai Zhao, Xue-Yan Wang, Jian-Hua Qin, Xi-Yan Dong   +6 more
doaj   +1 more source

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes

The FEBS Journal, EarlyView.
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni, Gabriel Oanca, Marco Orlando, Marina Lotti, Johan Åqvist, Marco Mangiagalli   +5 more
wiley   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

The FEBS Journal, EarlyView.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan, Aden Dhana Rizkita, Hsin‐Ju Hsieh, Shu‐Fang Hsu, Tony Eight Lin, Wei‐Jan Huang, Kai‐Cheng Hsu, Sheila Nathan, Peiching Chang, Andrew H.‐J. Wang, Cheng‐Chung Lee   +10 more
wiley   +1 more source

Stardust Mine: A 2024 gabbroic shergottite from Arizona, USA

Meteoritics &Planetary Science, EarlyView.
Abstract This study provides an initial characterization of Stardust Mine, a fresh gabbroic enriched shergottite collected in Arizona, USA, in September 2024 and is the first Martian meteorite to be unequivocably collected on US soil. Analysis was conducted on the type specimen and finds that Stardust Mine is composed of equal proportions of pyroxene ...
Jennifer T. Mitchell, Natasha R. Stephen, Zsuzsanna P. Allerton, Weiming Ding, Xin‐Yuan Zheng   +4 more
wiley   +1 more source