Results 31 to 40 of about 6,443 (221)
Crystals, 2016 Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development.
Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang
doaj +1 more source
Cocrystallization of Antifungal Compounds Mediated by Halogen Bonding
Crystal Growth & Design, 2023 The application of halogen bonding in pharmaceutical chemistry remains a challenge. In this work, novel halogen-bonded cocrystals based on azole antifungal active pharmaceutical ingredients (APIs) and the ditopic molecule 1,4-diiodotetrafluorobenzene are reported.
Mónica Benito +2 more
openaire +4 more sources
Recent Progress on Synthesis, Characterization, and Performance of Energetic Cocrystals: A Review
Molecules, 2022 In the niche area of energetic materials, a balance between energy and safety is extremely important. To address this “energy–safety contradiction”, energetic cocrystals have been introduced.
Manzoor Sultan +7 more
doaj +1 more source
Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications
Pharmaceutics, 2021 Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that contain
Isabela Fanelli Barreto Biscaia +3 more
doaj +1 more source
Pharmaceutics, 2022 The application of a computational screening methodology based on the calculation of intermolecular interaction energies has guided the discovery of new multicomponent solid forms of the oral antiviral Adefovir Dipivoxyl.
Rafael Barbas +7 more
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Angewandte Chemie, EarlyView.Multiphotochromic switching is controlled by silicon valency in a diarylethene‐based molecular architecture. Lewis base coordination gates electronic communication between the photochromic units, thereby enabling selective access to distinct switching states.
Lennart Stoess +2 more
wiley +2 more sources
Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
Pharmaceutics, 2022 Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL).
Yihua Jiang +7 more
doaj +1 more source
Nucleophilic Gallyl Anions Enable Ga─Au Bimetallic Ammonia Activation
Angewandte Chemie, EarlyView.Unlocking gallyl nucleophiles: Counterion control enables formation of an unsupported gallyl─gold complex. Gold coordination induces a polarity switch at gallium, enabling cooperative activation of NH3 and related N─H/O─H substrates under mild conditions.
Hellen Videa +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Glycine molecules induce a unique crystal packing into a supramolecular one‐dimensional columnar structure of octacyanidotungstates, which exhibits exceptionally strong antiferromagnetic superexchange interactions of J = −42.41(2) K between adjacent octacyanidotungstate units.
Tatsuya Konishi +8 more
wiley +2 more sources
Pharmaceutics, 2021 A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms
Hanan Fael +4 more
doaj +1 more source