Results 21 to 30 of about 4,408 (188)
Matrix Assisted Cocrystallization as an example of continuous and scalable method of obtaining pharmaceutical cocrystals on an industrial scale [PDF]
Farmacja Polska, 2021 Cocrystals can be defined as crystalline solids composed of at least two compounds in a stoichiometric ratio which interact nonionically. While one of the components is an active pharmaceutical ingredient (API) the term ‘pharmaceutical cocrystal’ could ...
Anna Magdalena Gołkowska +3 more
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Achieving Balanced Energetics through Cocrystallization [PDF]
Angewandte Chemie, 2019 AbstractAchieving energetic materials with a balanced ratio of oxidant to fuel is a challenge that has been difficult to meet through molecular synthesis. The alternative approach, composite formulation, fails to achieve intimate association of the components to the detriment of performance.
Michael K. Bellas, Adam J. Matzger
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Crystals, 2016 Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development.
Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang
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Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
Frontiers in Pharmacology, 2021 The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size
Ravi Kumar Bandaru +7 more
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Exploring the cocrystallization potential of urea and benzamide [PDF]
Journal of Molecular Modeling, 2016 The cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique.
Cysewski, Piotr +3 more
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Cocrystallization of Antifungal Compounds Mediated by Halogen Bonding
Crystal Growth & Design, 2023 The application of halogen bonding in pharmaceutical chemistry remains a challenge. In this work, novel halogen-bonded cocrystals based on azole antifungal active pharmaceutical ingredients (APIs) and the ditopic molecule 1,4-diiodotetrafluorobenzene are reported.
Mónica Benito +2 more
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Recent Progress on Synthesis, Characterization, and Performance of Energetic Cocrystals: A Review
Molecules, 2022 In the niche area of energetic materials, a balance between energy and safety is extremely important. To address this “energy–safety contradiction”, energetic cocrystals have been introduced.
Manzoor Sultan +7 more
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Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications
Pharmaceutics, 2021 Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that contain
Isabela Fanelli Barreto Biscaia +3 more
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Pharmaceutics, 2022 The application of a computational screening methodology based on the calculation of intermolecular interaction energies has guided the discovery of new multicomponent solid forms of the oral antiviral Adefovir Dipivoxyl.
Rafael Barbas +7 more
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Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
Pharmaceutics, 2022 Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL).
Yihua Jiang +7 more
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