Results 11 to 20 of about 4,408 (188)
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
doaj +4 more sources
Competitive cocrystallization and its application in the separation of flavonoids [PDF]
IUCrJ, 2021 Recently, cocrystallization has been widely employed to tailor physicochemical properties of drugs in the pharmaceutical field. In this study, cocrystallization was applied to separate natural compounds with similar structures.
Yanming Xia +5 more
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Tuning the Pharmacokinetic Performance of Quercetin by Cocrystallization
Crystal Growth & Design, 2023 Quercetin (QUE) is a widely studied nutraceutical with a number of potential therapeutic properties. Although QUE is abundant in the plant kingdom, its poor solubility (≤20 μg/mL) and poor oral bioavailability have impeded its potential utility and clinical development. In this context, cocrystallization has emerged as a useful method for improving the
Molly M. Haskins +9 more
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Screening of coformers for quercetin cocrystals through mechanochemical methods
Eclética Química, 2022 Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects.
Fayene Zeferino Ribeiro de Souza +4 more
doaj +1 more source
Journal of Food Quality, 2022 Cocrystallization, vacuum drying, and plating are three potential applications to preserve the antioxidant activity of moringa leaves. Moringa leaves extract was incorporated with sucrose at the same concentration (7 : 100, solid : solid) for all ...
Bambang Nurhadi +4 more
doaj +1 more source
Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals
Pharmaceutics, 2023 In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the successful combination of the drug with the positional isomers of acetamidobenzoic acid.
Artem O. Surov +5 more
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Pharmaceutical Cocrystals—A Review
Proceedings, 2021 The design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and ...
Sheetal S. Buddhadev, Kevin C. Garala
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Multicomponent Solids of Niflumic and Mefenamic Acids Based on Acid-Pyridine Synthon
Frontiers in Chemistry, 2022 The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers.
Vineet Kumar +5 more
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Crystals, 2023 Pyruvic acid is an organic compound used in various fields (e.g., the pharmaceutical, cosmetic, food, and chemical industries) and subject to constantly growing demand.
Camila Caro Garrido +4 more
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Cocrystallization of Nutraceuticals
Crystal Growth & Design, 2015 Cocrystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of compounds used as active pharmaceutical ingredients (APIs), complementing more traditional methods such as salt formation.
Sinha, Abhijeet S. +2 more
openaire +2 more sources