Results 81 to 90 of about 4,408 (188)

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

A chiral diamine: practical implications of a three-stereoisomer cocrystallization

Acta Crystallographica Section C Structural Chemistry, 2018
A brief comparison of seven straightforward methods for molecular crystal-volume estimation revealed that their precisions are comparable. A chiral diamine, N 2,N 3-bis[2,6-bis(propan-2-yl)phenyl]butane-2,3-diamine, C28H44N2, has been used to illustrate the application of the methods.
Brian S. Dolinar, Kerim Samedov, Andrew G. P. Maloney, Robert West, Victor N. Khrustalev, Ilia A. Guzei   +5 more
openaire   +4 more sources

Host–Guest Cocrystallization of Phenanthrene[2]arene Macrocycles Facilitating Structure Determination of Liquid Organic Molecules

Molecules
Single-crystal X-ray diffraction analysis has emerged as the most reliable method for determining the structures of organic molecules. However, numerous analytes, such as liquid organic molecules, pose challenges in crystallization, making their ...
Guangchuan Ou, Yanfeng Zhang, Qiong Wang, Yingzhi Tan, Qiang Zhou, Fei Zeng   +5 more
doaj   +1 more source

Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko, Raitis Bobrovs, Katrīna Freimane, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +6 more
wiley   +1 more source

Thermal and Rheological Properties of Fischer–Tropsch Wax/High‐Flow LLDPE Blends

Macromolecular Materials and Engineering
Waxes find use as processing aids in filled compounds and polyethylene‐based masterbatches. In such applications, the thermal and physical property changes they impart to the polymer matrix are important.
Thobile Mhlabeni, Shatish Ramjee, Jorge López, Ana‐María Díaz‐Díaz, Ramón Artiaga, Walter Focke   +5 more
doaj   +1 more source

A hydrogen-bonded channel structure formed by a complex of uracil and melamine

Beilstein Journal of Organic Chemistry, 2007
The structure of a 1:1 complex of uracil and melamine obtained by cocrystallization has been investigated. The structure involves hydrogen bonded layers with apertures stacked along the a and b directions giving rise to channels, unlike the complex of ...
Reji Thomas, G. U. Kulkarni
doaj   +1 more source

Characterization of CL-20/HMX cocrystallization and its effects on GAP-based propellants during thermal aging process

Polymer Testing
The incorporation of HMX and CL-20 as component particles can greatly improve the energy efficiency of composite propellants. Nevertheless, the occurrence of cocrystallization arises when HMX and CL-20 exists together.
Jiangtao Wang, Guanglong Zhang, Xiangyang Liu, Ningfei Wang   +3 more
doaj   +1 more source

Cocrystallization of GABA adducts [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2011
N. Khosavithitkul, K. J. Haller
openaire   +1 more source

Low-temperature cocrystallization [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 1993
D. Mootz, W. Poll
openaire   +1 more source

Cocrystallization of amino acids [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2011
S. A. Raza, I. D. H. Oswald
openaire   +1 more source