Results 91 to 100 of about 6,443 (221)
ChemMedChem, Volume 21, Issue 12, 26 June 2026.Four isostructural complexes (C1–C4) derived from 2‐(tert‐butoxy)‐6‐(1H‐imidazol‐1‐yl)pyridine with axial halides exhibit octahedral trans M(L)4X2 geometries, confirmed by X‐ray diffraction. They feature a discrete 1,6M7−1 topology, identified using ToposPro analysis.
David Ezenarro‐Salcedo +10 more
wiley +1 more source
European Journal of Inorganic Chemistry, Volume 29, Issue 17, 17 June 2026.Intramolecular (RO)2PO→Halogen interaction versus intermolecular (RO)2PO···HOH hydrogen bonds. Although the O···I distance is shorter than the sum of the van der Waals radii of the atoms involved, there is no covalency involved in this interaction.
David Mross +6 more
wiley +1 more source
A chiral diamine: practical implications of a three-stereoisomer cocrystallization
Acta Crystallographica Section C Structural Chemistry, 2018 A brief comparison of seven straightforward methods for molecular crystal-volume estimation revealed that their precisions are comparable. A chiral diamine, N 2,N 3-bis[2,6-bis(propan-2-yl)phenyl]butane-2,3-diamine, C28H44N2, has been used to illustrate the application of the methods.
Brian S. Dolinar +5 more
openaire +4 more sources
Cocrystallization of nutraceuticals
, 2014 Cocrystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of compounds used as active pharmaceutical ingredients (APIs), complementing more traditional methods such as salt formation.
Lawrence, Simon E. +2 more
core
, 2023 Pharmaceutical cocrystals are crystalline materials composed of at least two molecules, i.e., an active pharmaceutical ingredient (API) and a coformer, assembled by noncovalent forces.
Rubina Novelli (11681443) +17 more
core +1 more source
A Novel Insensitive Cocrystal Explosive Composed of BTF and the Non-Energetic 2-Nitroaniline
CrystalsBenzotrifuroxan (BTF) is a powerful energetic material (EM) with high density that can be used both as a primary and a secondary explosive. However, high mechanical sensitivity limits its application prospects.
Sijia Du +5 more
doaj +1 more source
Computational screens can speed up the discovery of pharmaceutical cocrystals
ADMET and DMPK, 2018 The calculation of Surface Site Interaction Points for cocrystal computational screens in combination with efficient experimental cocrystallization techniques has been applied successfully to several drug compounds.
Rafel Prohens, Christopher A Hunter
doaj +1 more source
Vapochemical cocrystallization of nicotinamide and dicarboxylic acids
, 2016 Nikotīnamīda un dikarbonskābju kokristālu tvaikķīmiskas veidošanās izpēte. Ķeķe A., darba vadītāja vadošā pētniece Dr. chem. Orola L. Bakalaura darbs, 41 lappuses, 27 attēli, 1 tabula, 40 literatūras avoti. Latviešu valodā.
Ķeķe, Anete
core
, 2018 Reducing effectively toxic side effects is a challenging subject in drug development. The reported herein cocrystallization of pyrazinamide with quercetin has complementary advantages, enhancing the in vitro/vivo performance of quercetin and taming the ...
Ling-Yang Wang (5352554) +4 more
core +1 more source
Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2
ChemMedChem, Volume 21, Issue 11, 15 June 2026.A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa +20 more
wiley +1 more source