Results 1 to 10 of about 698 (167)

Simultaneous quantification of drug and coformer during cocrystal dissolution using in situ UV spectroscopy and multicomponent analysis [PDF]

ADMET and DMPK
Background and purpose: The primary objective of this study was to assess the feasibility of applying in situ UV spectroscopy in combination with multicomponent analysis (MCA) to simultaneously quantify the dissolution of a drug and its coformer from a ...
Shiori Ishida, Samuel Lee, Balint Sinko, Karl Box, Kiyohiko Sugano   +4 more
doaj   +2 more sources

Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems

Pharmaceutics, 2023
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability present a significant challenge during their processing into final dosage forms.
Maan Singh, Harsh Barua, Vaskuri G. S. Sainaga Jyothi, Madhukiran R. Dhondale, Amritha G. Nambiar, Ashish K. Agrawal, Pradeep Kumar, Nalini R. Shastri, Dinesh Kumar   +8 more
doaj   +3 more sources

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

Pharmaceuticals, 2023
In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar, Santanu Chakraborty, Souvik Basak, Paramita Pattanayak, Tanmay Chatterjee, Balaram Ghosh, Mohamed Raafat, Mohammed A. S. Abourehab   +7 more
doaj   +3 more sources

Application of cosolvency and cocrystallization approach to enhance acyclovir solubility [PDF]

BMC Chemistry
Acyclovir (ACY) is a commonly used antiviral drug with limited aqueous solubility and poor permeability. It is administered via oral and intravenous routes.
Elham Azad Khiabani, Abolghasem Jouyban, Anahita Fathi Azarbayjani   +2 more
doaj   +2 more sources

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals

Acta Pharmaceutica Sinica B, 2019
Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic
Shuzhen Ren, Mingyu Liu, Chao Hong, Guowen Li, Jiabin Sun, Jianying Wang, Lei Zhang, Yan Xie   +7 more
doaj   +3 more sources

Driving Forces in the Formation of Paracetamol Cocrystals and Solvate with Naphthalene, Quinoline and Acridine [PDF]

Molecules
Paracetamol is an important analgesic and antipyretic drug showing poor tabletability. Among the various approaches used to improve this property, understanding the forces that govern the crystal packing is revealed to be crucial.
Tadeusz M. Muzioł, Emilia Bronikowska
doaj   +2 more sources

Solubility improvement of atorvastatin using deep eutectic solvents [PDF]

Journal of Advanced Pharmaceutical Technology & Research
Deep eutectic solvents (DESs) in pharmaceutical investigations are still largely unknown in terms of safety, environmental acceptability, and practical use.
Yoga Windhu Wardhana, Insan Sunan Kurniawansyah, Taofik Rusdiana   +2 more
doaj   +2 more sources

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

International Journal of Nanomedicine
Arif Budiman,1 Yoga Windhu Wardhana,1 Ahmad Ainurofiq,2 Yuda Prasetya Nugraha,3 Ridhatul Qaivani,4 Siti Nazila Awaliyyah Lukmanul Hakim,4 Diah Lia Aulifa4 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas ...
Budiman A, Wardhana YW, Ainurofiq A, Nugraha YP, Qaivani R, Lukmanul Hakim SNA, Aulifa DL   +6 more
doaj   +2 more sources

Engineering cocrystals of Paliperidone with enhanced solubility and dissolution characteristics [PDF]

Arhiv za farmaciju, 2021
In the present study, co-crystals (CCs) of Paliperidone (PPD) with coformers like benzoic acid (BA) and P-amino benzoic acid (PABA) were synthesized and characterized to improve the physicochemical properties and dissolution rate.
Radha-Rani Earle, Venkata-Radha Gadela
doaj   +1 more source

Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation

Future Journal of Pharmaceutical Sciences, 2023
Background The objective of the present investigation was to obtain directly compressible agglomerates of ibuprofen with nicotinamide by a quasi-emulsification solvent diffusion technique.
Prerna Hemant Sidwadkar, Nitin Hindurao Salunkhe, Kailas Krishnat Mali, Vijay Bapu Metkari, Durgesh Paresh Bidye   +4 more
doaj   +1 more source