Results 41 to 50 of about 698 (167)

Isomorphism: `molecular similarity to crystal structure similarity' in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid

IUCrJ, 2020
The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA.
Subham Ranjan, Ramesh Devarapalli, Sudeshna Kundu, Subhankar Saha, Shubham Deolka, Venu R. Vangala, C. Malla Reddy   +6 more
doaj   +1 more source

Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals

Pharmaceuticals, 2023
Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez, Carolina Alarcón-Payer, Cristóbal Verdugo-Escamilla, Jesús Martín, Antonio Frontera, Alicia Domínguez-Martín, Jaime Gómez-Morales, Duane Choquesillo-Lazarte   +7 more
doaj   +1 more source

Polymorphism basics and cocrystal technology.

Journal of Excipients and Food Chemicals, 2023
The adoption of cocrystals into oral pharmaceutical formulations is expected to propel this, as yet, moribund field into clinical and monetary prominence.
Shireesh P Apte, Mathew Cherian
doaj  

Properadic coformality of spheres

International Mathematics Research Notices
Abstract We define a properad $\mathcal{Y}^{(n)}_\infty $ that encodes $n$-pre-Calabi–Yau algebras with vanishing copairing. These algebras include chains on the based loop space of any space $X$ endowed with a fundamental class $[X]$ such that $(X,[X])$ satisfies Poincaré duality of degree $n \geqslant 1$ with local system ...
Emprin, Coline, Takeda, Alex
openaire   +2 more sources

Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules, 2021
Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has
Ilma Nugrahani, Maria Anabella Jessica
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Cocrystallization of acetaminophen and glutaric acid with different coformers [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Recently cocrystallization became a popular tool for crystal engineering that allows, for instance, improving properties of pharmaceutical materials, creating new materials for nonlinear optical applications and solar cell technologies. To attract students to crystallographic studies we carried out project that included crystal growth of two series of ...
Tatiana Timofeeva, Sofia Antal, Sergiu Draguta, Karla Ordonez, Raul Castaneda, Evgeniya Leonova   +5 more
openaire   +1 more source

Interaction Analysis using the Cambridge Structural Database – rapid access to intermolecular hydrogen‐bond frequencies and uses for coformer selection

Acta Crystallographica Section B, EarlyView.
We describe a coformer selection tool that uses knowledge of functional group interactions found in the Cambridge Structural Database to quickly identify complementary molecules to the target.A new methodology to perform virtual coformer screening, utilising data gathered on hydrogen‐bonding interactions present in the organic subset of the Cambridge ...
Joanna S. Stevens, Andrew G. P. Maloney, Elna Pidcock   +2 more
wiley   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

Sildenafil–Resorcinol Cocrystal: XRPD Structure and DFT Calculations

Crystals, 2020
Herein, the X-ray powder diffraction (XRPD) crystal structure of a new Sildenafil cocrystal is reported, where resorcinol has been used as the coformer.
Rafael Barbas, Vineet Kumar, Oriol Vallcorba, Rafel Prohens, Antonio Frontera   +4 more
doaj   +1 more source