Results 41 to 50 of about 1,272 (143)
, 2022 Model-based optimization of cocrystallization processes involves the simultaneous identification of the optimal coformer and solvent types and the process operating conditions, which should suppress the formation of undesirable solid-state forms.
Richard Lakerveld +3 more
core +1 more source
Polymorphism basics and cocrystal technology.
Journal of Excipients and Food Chemicals, 2023 The adoption of cocrystals into oral pharmaceutical formulations is expected to propel this, as yet, moribund field into clinical and monetary prominence.
Shireesh P Apte, Mathew Cherian
doaj
, 2017 A highly soluble cocrystal of a poorly soluble drug has the potential to improve the dissolution rate and bioavailability. Reaping the potential dissolution advantage of soluble cocrystals is challenged by the precipitation of the parent drug during ...
Changquan Calvin Sun (812250) +1 more
core +1 more source
Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin
CrystalsThis study explores the co-crystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal.
Camila Caro Garrido +5 more
doaj +1 more source
Systematic coformer contribution to cocrystal stabilization : energy and packing trends
, 2020 : Polycyclic aromatic compounds such as acridine and phenazine are popular molecular partners used in cocrystal synthesis. The intermolecular interactions occurring between coformers and their molecular partners dominate the cocrystal packing energy, but
Bacchi, Alessia +9 more
core +1 more source
Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review
Molecules, 2021 Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has
Ilma Nugrahani, Maria Anabella Jessica
doaj +1 more source
Synchronization of Cocrystal Dissolution and Drug Precipitation to Sustain Drug Supersaturation
, 2022 A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram.
Tatiane Cogo Machado (13046209) +3 more
core +2 more sources
Sildenafil–Resorcinol Cocrystal: XRPD Structure and DFT Calculations
Crystals, 2020 Herein, the X-ray powder diffraction (XRPD) crystal structure of a new Sildenafil cocrystal is reported, where resorcinol has been used as the coformer.
Rafael Barbas +4 more
doaj +1 more source
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
Acta Pharmaceutica Sinica B, 2021 Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients.
Minshan Guo +3 more
doaj +1 more source
Scientific Coformer Screening, Preparation and Evaluation of Fenofibrate Tartaric Acid Cocrystal
, 2019 Objective: This present study aims to screen pharmaceutical cocrystal of Fenofibrate and coformers. Further the preparation and evaluation of fenofibrate-coformer cocrystal and In-Vitro drug release and Ex-Vivo Permeation study was done.
Pradhan, Sumedh Bandu, Bhalekar, Mangesh
core +1 more source