Results 31 to 40 of about 1,272 (143)

Solubility improvement of atorvastatin using deep eutectic solvents. [PDF]

J Adv Pharm Technol Res
Deep eutectic solvents (DESs) in pharmaceutical investigations are still largely unknown in terms of safety, environmental acceptability, and practical use.
Wardhana YW, Kurniawansyah IS, Rusdiana T.   +2 more
europepmc   +2 more sources

Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide

Future Journal of Pharmaceutical Sciences, 2020
Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs.
Shivarani Eesam, Jaswanth S. Bhandaru, Chandana Naliganti, Ravi Kumar Bobbala, Raghuram Rao Akkinepally   +4 more
doaj   +1 more source

Driving Forces in the Formation of Paracetamol Cocrystals and Solvate with Naphthalene, Quinoline and Acridine. [PDF]

Molecules
Paracetamol is an important analgesic and antipyretic drug showing poor tabletability. Among the various approaches used to improve this property, understanding the forces that govern the crystal packing is revealed to be crucial.
Muzioł TM, Bronikowska E.
europepmc   +2 more sources

A Review of Coformer Utilization in Multicomponent Crystal Formation

Molecules, 2022
Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness.
Nasrul Wathoni, Wuri Ariestika Sari, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Ine Suharyani   +4 more
doaj   +1 more source

Formation of a Stable Co-Amorphous System for a Brick Dust Molecule by Utilizing Sodium Taurocholate with High Glass Transition Temperature

Pharmaceutics, 2022
Brick dust molecules are usually poorly soluble in water and lipoidal components, making it difficult to formulate them in dosage forms that provide efficient pharmacological effects. A co-amorphous system is an effective strategy to resolve these issues.
Shohei Aikawa, Hironori Tanaka, Hiroshi Ueda, Masato Maruyama, Kazutaka Higaki   +4 more
doaj   +1 more source

Oxalic Acid, a Versatile Coformer for Multicomponent Forms with 9-Ethyladenine

Crystals, 2022
Six new multicomponent solids of 9-ethyladenine and oxalic acid have been detected and characterized. The salt screening has been performed by mechanochemical and solvent crystallization processes.
Mónica Benito, Miquel Barceló-Oliver, Antonio Frontera, Elies Molins   +3 more
doaj   +1 more source

Exploration of Fulvic Acid as a Co-Former in Crystal Engineering

Separations, 2022
The aim of the project was to investigate Peat-derived Fulvic acid for its propensity to form co-crystals with quercetin and curcumin and characterize it by using different analytical techniques.
Kattamanchi Gnananath, Kolli Prabhanjan Kumar, Yejella Rajendra Prasad, Kalakonda Sri Nataraj, Mohamad Taleuzzaman, Mohammad Javed Ansari, Mohd. Aamir Mirza   +6 more
doaj   +1 more source

Isomorphism: `molecular similarity to crystal structure similarity' in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid

IUCrJ, 2020
The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA.
Subham Ranjan, Ramesh Devarapalli, Sudeshna Kundu, Subhankar Saha, Shubham Deolka, Venu R. Vangala, C. Malla Reddy   +6 more
doaj   +1 more source

Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals

Pharmaceuticals, 2023
Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez, Carolina Alarcón-Payer, Cristóbal Verdugo-Escamilla, Jesús Martín, Antonio Frontera, Alicia Domínguez-Martín, Jaime Gómez-Morales, Duane Choquesillo-Lazarte   +7 more
doaj   +1 more source

Rational Coformer or Solvent Selection for Pharmaceutical Cocrystallization or Desolvation

, 2012
Rational coformer or solvent selection for pharmaceutical co-crystallization or ...
Klamt, Andreas, Abramov, Yuriy A., Loschen, Christoph   +2 more
core   +1 more source