Results 31 to 40 of about 698 (167)
Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization
Crystal Growth & Design, 2022 Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs) through cocrystallization is an important part of drug product development. However, it is difficult to know a priori which coformers will form cocrystals with a given API, and the current state-of-the-art for cocrystal discovery involves an expensive, time ...
Isaac J. Sugden +4 more
openaire +2 more sources
Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide
Future Journal of Pharmaceutical Sciences, 2020 Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs.
Shivarani Eesam +4 more
doaj +1 more source
Pharmaceutics, 2022 Brick dust molecules are usually poorly soluble in water and lipoidal components, making it difficult to formulate them in dosage forms that provide efficient pharmacological effects. A co-amorphous system is an effective strategy to resolve these issues.
Shohei Aikawa +4 more
doaj +1 more source
On the rational topological complexity of coformal elliptic spaces
Journal of Pure and Applied Algebra, 2023 We establish some upper and lower bounds of the rational topological complexity for certain classes of elliptic spaces. Our techniques permit us in particular to show that the rational topological complexity coincides with the dimension of the rational homotopy for some special families of coformal elliptic spaces.
Hamoun, Said +2 more
openaire +3 more sources
Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals
Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley +2 more sources
Exploration of Fulvic Acid as a Co-Former in Crystal Engineering
Separations, 2022 The aim of the project was to investigate Peat-derived Fulvic acid for its propensity to form co-crystals with quercetin and curcumin and characterize it by using different analytical techniques.
Kattamanchi Gnananath +6 more
doaj +1 more source
Pharmaceutics, 2023 This study describes the preparation, characterization, and influence of the enantiopure vs. racemic coformer on the physico-chemical properties of a pharmaceutical cocrystal.
Panpan Ma +17 more
doaj +1 more source
Computational Support to Explore Ternary Solid Dispersions of Challenging Drugs Using Coformer and Hydroxypropyl Cellulose [PDF]
Molecular PharmaceuticsAndreas Niederquell +2 more
exaly +2 more sources
Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin
CrystalsThis study explores the co-crystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal.
Camila Caro Garrido +5 more
doaj +1 more source
Indonesian Journal of Chemistry, 2019 Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid ...
Yudi Wicaksono +3 more
doaj +1 more source