Future Journal of Pharmaceutical Sciences, 2021 Background Cocrystallization process involved the understanding of interaction at molecular level between two molecules in context to their crystal packing and designing of new solids having improved physicochemical as well as pharmaceutical properties ...
Braham Dutt +2 more
doaj +1 more source
Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability
Proceedings, 2021 In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach.
Tanmoy Ghosh +3 more
doaj +1 more source
Transformation pathways of cocrystal hydrates when coformer modulates water activity [PDF]
, 2010 An important attribute of cocrystals is that their properties can be tailored to meet required solubility and stability specifications. But before such practical uses can be realized, a better understanding of the factors that dictate co-crystal behavior
Roy, Lilly +5 more
core +1 more source
Cocrystallization approach: Dissolution rate enhancement of carbamazepine with various coformers and virtual screening tools [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cocrystallization is a promising solid-state modification used to enhance the dissolution rate and solubility of poorly water-soluble drugs, such as carbamazepine.
Taofik Rusdiana +3 more
doaj +1 more source
Molecules, 2020 This work aims at unraveling the effects of co-crystallization on the optical properties of an N-salicylideneaniline-derived molecular switch transforming between an enol and a keto form. This is achieved by way of a two-step multi-scale method where (i)
Jean Quertinmont +3 more
doaj +1 more source
STUDI IN SILICO PEMBENTUKAN KOKRISTAL MELOXICAM DENGAN BERBAGAI KOFORMER PERBANDINGAN (1 : 1)
JIIS: Jurnal Ilmiah Ibnu Sina, 2023 Kokristal merupakan salah satu bentuk modifikasi dalam meningkatkan kelarutan dari meloxicam yang termasuk dalam Biopharmaceutics Classifications System (BCS) II. Kokristal adalah sistem multikomponen dengan perbandingan stoikiometeri antara bahan aktif
Yuli Ainun Najih +3 more
doaj +1 more source
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
doaj +1 more source
Prediction of Cocrystal Formation Between Drug and Coformer by Simple Structural Parameters
, 2022 Background: Cocrystal formation between an active pharmaceutical ingredient (API) and coformer is an applicable technique to change the physicochemical and pharmacokinetic properties.
Shayanfar, Shadi, +3 more
core +1 more source
Identification of Photocatalytic Alkaloids from Coptidis Rhizome by an Offline HPLC/CC/SCD Approach
Molecules, 2022 Natural products continue to be a valuable source of active metabolites; however, researchers of natural products are mostly focused on the biological effects, and their chemical utility has been less explored. Furthermore, low throughput is a bottleneck
Shu-Qin Qin +5 more
doaj +1 more source
Impact of the Coformer Carbon-Chain Length on the Properties of Haloperidol Pharmaceutical Salts. [PDF]
Cryst Growth DesHaloperidol (HAL) is a conventional antipsychotic drug with poor aqueous solubility, which is associated with a major risk of side effects. In this context, crystal engineering has provided an efficient approach for tuning the physicochemical properties ...
Acebedo-Martínez FJ +5 more
europepmc +2 more sources