Results 21 to 30 of about 698 (167)

Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability

Proceedings, 2021
In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach.
Tanmoy Ghosh, Thimmasetty Juturu, Shashank Nayak Nagar, Shwetha Kamath   +3 more
doaj   +1 more source

Cocrystallization approach: Dissolution rate enhancement of carbamazepine with various coformers and virtual screening tools [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Cocrystallization is a promising solid-state modification used to enhance the dissolution rate and solubility of poorly water-soluble drugs, such as carbamazepine.
Taofik Rusdiana, Fitrianti Darusman, Iyan Sopyan, Silvi S. Putri   +3 more
doaj   +1 more source

Preparation, characterization and evaluation of fenofibrate: benzoic acid cocrystals with enhanced pharmaceutical properties

Future Journal of Pharmaceutical Sciences, 2021
Background Cocrystallization process involved the understanding of interaction at molecular level between two molecules in context to their crystal packing and designing of new solids having improved physicochemical as well as pharmaceutical properties ...
Braham Dutt, Manjusha Choudhary, Vikas Budhwar   +2 more
doaj   +1 more source

Double Salts and Racemate in Mefloquine-Ibuprofen and Mefloquine-Ketoprofen Systems. A Structural and Thermochemical Analysis. [PDF]

Chirality
(S)‐ibuprofen or ketoprofen were used to resolve mefloquine, forming double salts structurally similar to the racemic forms. ABSTRACT The formation of salts remains a highly sought‐after yet unpredictable strategy for resolving chiral drugs. Using a drug–drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic ...
Martins JB, Segatto JV, Tenorio JC, Carvalho PS.   +3 more
europepmc   +2 more sources

Unraveling the Effects of Co-Crystallization on the UV/Vis Absorption Spectra of an N-Salicylideneaniline Derivative. A Computational RI-CC2 Investigation

Molecules, 2020
This work aims at unraveling the effects of co-crystallization on the optical properties of an N-salicylideneaniline-derived molecular switch transforming between an enol and a keto form. This is achieved by way of a two-step multi-scale method where (i)
Jean Quertinmont, Tom Leyssens, Johan Wouters, Benoît Champagne   +3 more
doaj   +1 more source

Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi, Yacoub Al-Basarah, Aly Nada   +2 more
doaj   +1 more source

Identification of Photocatalytic Alkaloids from Coptidis Rhizome by an Offline HPLC/CC/SCD Approach

Molecules, 2022
Natural products continue to be a valuable source of active metabolites; however, researchers of natural products are mostly focused on the biological effects, and their chemical utility has been less explored. Furthermore, low throughput is a bottleneck
Shu-Qin Qin, Jun Ma, Qi-Qi Wang, Wei Xu, Wen-Cai Ye, Ren-Wang Jiang   +5 more
doaj   +1 more source

Coformality around fibrations and cofibrations

Homology, Homotopy and Applications, 2023
We show that in a fibration the coformality of the base space implies the coformality of the total space under reasonable conditions, and these conditions can not be weakened. The result is partially dual to the classical work of Lupton \cite{Lup} on the formality within a fibration. Our result has two applications.
openaire   +2 more sources

Rational Coformer or Solvent Selection for Pharmaceutical Cocrystallization or Desolvation [PDF]

Journal of Pharmaceutical Sciences, 2012
It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization.
Abramov, Yuriy A., Loschen, Christoph, Klamt, Andreas   +2 more
openaire   +2 more sources

STUDI IN SILICO PEMBENTUKAN KOKRISTAL MELOXICAM DENGAN BERBAGAI KOFORMER PERBANDINGAN (1 : 1)

JIIS: Jurnal Ilmiah Ibnu Sina, 2023
Kokristal merupakan salah satu bentuk modifikasi dalam meningkatkan kelarutan dari meloxicam yang termasuk dalam Biopharmaceutics Classifications System (BCS) II. Kokristal adalah sistem multikomponen dengan perbandingan stoikiometeri antara bahan aktif
Yuli Ainun Najih, Farizah Izazi, Siswandono Siswandono, Bella Anggraini Putri   +3 more
doaj   +1 more source