Results 11 to 20 of about 698 (167)

A Review of Coformer Utilization in Multicomponent Crystal Formation

Molecules, 2022
Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness.
Nasrul Wathoni, Wuri Ariestika Sari, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Ine Suharyani   +4 more
doaj   +3 more sources

Oxalic Acid, a Versatile Coformer for Multicomponent Forms with 9-Ethyladenine [PDF]

Crystals, 2022
Six new multicomponent solids of 9-ethyladenine and oxalic acid have been detected and characterized. The salt screening has been performed by mechanochemical and solvent crystallization processes.
Mónica Benito, Miquel Barceló-Oliver, Antonio Frontera, Elies Molins   +3 more
doaj   +3 more sources

In Silico Coformer Screening for Mefenamic Acid Cocrystallization

Jurnal Info Kesehatan
Cocrystallization is a widely used approach to enhance the solubility and dissolution characteristics of poorly soluble drugs. A pharmaceutical cocrystal is a multicomponent system composed of a solid active pharmaceutical ingredient (API) and a coformer,
Aulia Fikri Hidayat, Taufik Muhammad Fakih, Gita Cahya Eka Darma, Ratu Choesrina   +3 more
doaj   +2 more sources

Apremilast Cocrystals with Phenolic Coformers. [PDF]

Molecules
Apremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates the cocrystallization of APR with four phenolic-type coformers: phenol, catechol, pyrogallol, and hydroxyquinol. These coformers
Naumkina Y, Kratochvíl B, Korotkova E, Čejka J.   +3 more
europepmc   +4 more sources

Coformational Switch of Oligonucleotide Induced by Spermine [PDF]

Nucleic Acids Symposium Series, 2005
Conformational change of nucleic acids induced by a small molecule is essential for many biological reactions and useful for biotechnology. To construct a spermine-responsive nucleic acid, we designed DNA sequences which can potentially form a unimolecular hairpin loop structure and a bimolecular duplex by itself.
Toshimasa, Kirihata, Shu-ichi, Nakano, Satoshi, Fujii, Manabu, Matsumoto, Masayasu, Kuwahara, Hiroaki, Sawai, Naoki, Sugimoto   +6 more
openaire   +2 more sources

Cocrystals and Solvates are Not the Same: A Network Perspective. [PDF]

Chemphyschem
Based on network analysis, cocrystals and solvates cannot be treated the same. Cocrystals and solvates are two kinds of multicomponent crystals. Cocrystals consist of solid compounds, while solvates consist of a mixture of solid and liquid compounds. This work addresses the question of whether cocrystals and solvates can be treated the same or need to ...
de Vries TE, Meekes H, Vlieg E, de Gelder R.   +3 more
europepmc   +2 more sources

Enantioselectivity of chiral dihydromyricetin in multicomponent solid solutions regulated by subtle structural mutation

IUCrJ, 2023
Multicomponent crystals of a chiral drug with non-chiral components have attracted increasing attention in the application of enantiomer purification and regulation of the physicochemical properties of crystalline materials.
Jie Sun, Yaoguo Wang, Weiwei Tang, Junbo Gong   +3 more
doaj   +1 more source

Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method

Crystals, 2020
The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano, Megumi Kitahara, Kae Kishi, Eiichi Goto, Tatsuaki Tagami, Toshiro Fukami, Tetsuya Ozeki   +6 more
doaj   +1 more source

Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim

Crystal Growth & Design, 2022
The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C–NH2/N═C/C–NH2 and C–NH2/N═C interaction sites.
Lamis Alaa Eldin Refat, Ciaran O’Malley, John M. Simmie, Patrick McArdle, Andrea Erxleben   +4 more
openaire   +3 more sources

Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals

Pharmaceutics, 2020
Two, well defined binary crystals with 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide (HIMO) as coformer and thiobarbituric acid (TBA) as well barbituric acid (BA) as Active Pharmaceutical Ingredients (APIs) were obtained by cocrystallization (from methanol ...
Aneta Wróblewska, Justyna Śniechowska, Sławomir Kaźmierski, Ewelina Wielgus, Grzegorz D. Bujacz, Grzegorz Mlostoń, Arkadiusz Chworos, Justyna Suwara, Marek J. Potrzebowski   +8 more
doaj   +1 more source