Results 11 to 20 of about 1,272 (143)

Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals

Pharmaceutics, 2020
Two, well defined binary crystals with 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide (HIMO) as coformer and thiobarbituric acid (TBA) as well barbituric acid (BA) as Active Pharmaceutical Ingredients (APIs) were obtained by cocrystallization (from methanol ...
Grzegorz D. Bujacz, Ewelina Wielgus, Justyna Suwara, Aneta Wróblewska, Sławomir Kaźmierski, Grzegorz Mlostoń, Justyna Śniechowska, Arkadiusz Chworos, Marek J. Potrzebowski   +8 more
core   +2 more sources

New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties [PDF]

Pharmaceutics, 2023
This study describes the preparation, characterization, and influence of the enantiopure vs. racemic coformer on the physico-chemical properties of a pharmaceutical cocrystal.
ROBERTI, Enrica Angela, CORVIS, Yohann, DUFAT, Hanh, MA, Panpan, NÉGRIER, Philippe, Balthazar Toussaint, Cyrille Richard, GAMBERINI, Maria Cristina, Philippe Négrier, Stéphane Massip, SANTOS SILVA, Axel, BARALDI, Cecilia, Hanh Dufat, CASTILLO HENRÍQUEZ, Luis, Stéphane Veesler, TOUSSAINT, Balthazar, Karim Hammad, Monique Cadasse, Panpan Ma, ESPEAU, Philippe, VEESLER, Stéphane, Cecilia Baraldi, RICHARD, Cyrille, MASSIP, Stéphane, CADASSE, Monique, Yohann Corvis, Maria Cristina Gamberini, SCORNET, Noémie, Luis Castillo Henríquez, HAMMAD, Karim, Enrica Angela Roberti, Noémie Scornet, Axel Santos Silva, LEE, Tu, Tu Lee, Philippe Espeau   +35 more
core   +4 more sources

In Silico Coformer Screening for Mefenamic Acid Cocrystallization

Jurnal Info Kesehatan
Cocrystallization is a widely used approach to enhance the solubility and dissolution characteristics of poorly soluble drugs. A pharmaceutical cocrystal is a multicomponent system composed of a solid active pharmaceutical ingredient (API) and a coformer,
Hidayat, Aulia Fikri, Fakih, Taufik Muhammad, Choesrina, Ratu, Darma, Gita Cahya Eka   +3 more
core   +2 more sources

Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer

Indonesian Journal of Chemistry, 2019
Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid ...
Siswandono Siswandono, Dwi Setyawan, Tri Agus Siswoyo, Yudi Wicaksono   +3 more
core   +3 more sources

Engineering cocrystals of Paliperidone with enhanced solubility and dissolution characteristics [PDF]

Arhiv za farmaciju, 2021
In the present study, co-crystals (CCs) of Paliperidone (PPD) with coformers like benzoic acid (BA) and P-amino benzoic acid (PABA) were synthesized and characterized to improve the physicochemical properties and dissolution rate.
Radha-Rani Earle, Venkata-Radha Gadela
doaj   +1 more source

Application of cosolvency and cocrystallization approach to enhance acyclovir solubility. [PDF]

BMC Chem
Acyclovir (ACY) is a commonly used antiviral drug with limited aqueous solubility and poor permeability. It is administered via oral and intravenous routes.
Azad Khiabani E, Jouyban A, Fathi Azarbayjani A.   +2 more
europepmc   +2 more sources

Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation

Future Journal of Pharmaceutical Sciences, 2023
Background The objective of the present investigation was to obtain directly compressible agglomerates of ibuprofen with nicotinamide by a quasi-emulsification solvent diffusion technique.
Prerna Hemant Sidwadkar, Nitin Hindurao Salunkhe, Kailas Krishnat Mali, Vijay Bapu Metkari, Durgesh Paresh Bidye   +4 more
doaj   +1 more source

Enantioselectivity of chiral dihydromyricetin in multicomponent solid solutions regulated by subtle structural mutation

IUCrJ, 2023
Multicomponent crystals of a chiral drug with non-chiral components have attracted increasing attention in the application of enantiomer purification and regulation of the physicochemical properties of crystalline materials.
Jie Sun, Yaoguo Wang, Weiwei Tang, Junbo Gong   +3 more
doaj   +1 more source

Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method

Crystals, 2020
The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano, Megumi Kitahara, Kae Kishi, Eiichi Goto, Tatsuaki Tagami, Toshiro Fukami, Tetsuya Ozeki   +6 more
doaj   +1 more source

Adducts of N-Heterocyclic Drugs, Niacin, Allopurinol, and Amiloride, with 2,4-Pyridinedicarboxylic Acid Coformer

, 2020
A co-crystallization of three drug molecules, niacin (3-pyridine-carboxylic acid = NIA), allopurinol (pyrazolo(3,4-d)pyrimidin-4-one = ALP), and amiloride (3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine = AMI), with the same coformer, 2,4 ...
Lindline J., Timofeeva T.V., Khrustalev V.N., Averkiev B.B., Fonari M.S., Bejagam S.N.   +5 more
core   +2 more sources