Results 51 to 60 of about 1,272 (143)

Crystal structure of (Z)-N-benzylidene-1-phenylmethanamine oxide hydrogen peroxide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title adduct, C14H13NO·H2O2, consists of (Z)-N-benzylidene-1-phenylmethanamine oxide and hydrogen peroxide molecules in a 1:1 ratio. The organic coformer adopts a skew geometry with an inter-aryl-ring dihedral angle of 81.9 (2)°.
Andrei V. Churakov, Petr V. Prikhodchenko, Alexander G. Medvedev, Alexey A. Mikhaylov   +3 more
doaj   +1 more source

Cocrystals of Hydrochlorothiazide: Solubility and Diffusion/Permeability Enhancements through Drug-Coformer Interactions

, 2015
Hydrochlorothiazide (HCT) is a diuretic and a BCS class IV drug with low solubility and low permeability, exhibiting poor oral absorption. The present study attempts to improve the physicochemical properties of the drug using a crystal engineering ...
Devi, Kusum V, Desiraju, Gautam R, Clara, Deepa, Malviya, Nidhi, Ganguly, Somnath, Sanphui, Palash   +5 more
core   +2 more sources

A method for improving the properties of famotidine

Heliyon, 2023
According to crystal engineering, the pharmaceutical intermediate m-nitrobenzoic acid (MNBA), which contains a carboxylic acid group, was selected as a coformer (CCF) for drug cocrystallization with famotidine (FMT), and a new stable FMT salt cocrystal ...
Yongfeng Zhao, Ying Fan, Yan Zhang, Hong Xu, Min Li, Yunjie Zhu, Zhao Yang   +6 more
doaj   +1 more source

Coformer Replacement as an Indicator for Thermodynamic Instability of Cocrystals: Competitive Transformation of Caffeine:Dicarboxylic Acid

, 2016
YesThe thermodynamic stability of caffeine (CA) cocrystals with dicarboxylic acids (DAs) as coformers was investigated in the presence of a range of structurally related dicarboxylic acids (SRDs).
John Kendrick (1875505), Paradkar, Anant R, MHD. Bashir Alsirawan (2744674), Anant Paradkar (1472215), Vangala, Venu R., Alsirawan, M.H.D. Bashir, Kendrick, John, Venu R. Vangala (1410670), Frank J. J. Leusen (2026468), Leusen, Frank J.J., Alsirawan, MHD Bashir   +10 more
core   +1 more source

Screening of coformers for quercetin cocrystals through mechanochemical methods

Eclética Química, 2022
Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects.
Fayene Zeferino Ribeiro de Souza, Amanda Cosmo de Almeida, Patrícia Osorio Ferreira, Richard Perosa Fernandes, Flávio Junior Caires   +4 more
doaj   +1 more source

Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions

Molecules, 2020
Despite the technological importance of urea perhydrate (percarbamide) and sodium percarbonate, and the growing technological attention to solid forms of peroxide, fewer than 45 peroxosolvates were known by 2000.
Alexander G. Medvedev, Andrei V. Churakov, Petr V. Prikhodchenko, Ovadia Lev, Mikhail V. Vener   +4 more
doaj   +1 more source

A Two-Stage Approach to the Study of Potato Disease Severity Classification

Agriculture
Early blight and late blight are two of the most prevalent and severe diseases affecting potato crops. Efficient and accurate grading of their severity is crucial for effective disease management.
Yanlei Xu, Zhiyuan Gao, Jingli Wang, Yang Zhou, Jian Li, Xianzhang Meng   +5 more
doaj   +1 more source

Structural Characterization of Co-Crystals of Chlordiazepoxide with p-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-ray Diffraction, FTIR and Raman Spectroscopy

Pharmaceutics, 2020
The low water solubility of benzodiazepines seriously affects their bioavailability and, in consequence, their biological activity. Since co-crystallization has been found to be a promising way to modify undesirable properties in active pharmaceutical ...
Patrycja Garbacz, Dominik Paukszta, Artur Sikorski, Marek Wesolowski   +3 more
doaj   +1 more source

Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer

Pharmaceutics, 2022
Hesperetin (HES) is a key biological active ingredient in citrus peels, and is one of the natural flavonoids that attract the attention of researchers due to its numerous therapeutic bioactivities that have been identified in vitro.
Yanjie Liu, Fan Yang, Xiuhua Zhao, Siying Wang, Qilei Yang, Xiaoxue Zhang   +5 more
doaj   +1 more source

Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal

Brazilian Journal of Pharmaceutical Sciences, 2023
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF ...
Xintong Yang, Yang Chen, Ning Qiao
doaj   +1 more source