Results 51 to 60 of about 698 (167)
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
Acta Pharmaceutica Sinica B, 2021 Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients.
Minshan Guo +3 more
doaj +1 more source
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
Crystal structure of (Z)-N-benzylidene-1-phenylmethanamine oxide hydrogen peroxide monosolvate
Acta Crystallographica Section E: Crystallographic Communications, 2017 The title adduct, C14H13NO·H2O2, consists of (Z)-N-benzylidene-1-phenylmethanamine oxide and hydrogen peroxide molecules in a 1:1 ratio. The organic coformer adopts a skew geometry with an inter-aryl-ring dihedral angle of 81.9 (2)°.
Andrei V. Churakov +3 more
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Crystal Research and Technology, Volume 61, Issue 7, July 2026.Naringin and naringenin exhibit well‐recognized therapeutic potential; however, they face limitations related to solubility and bioavailability. Micronization increases surface area and enhances absorption. Notably, cocrystallization stands out as a primary strategy for particle optimization, as it refines physicochemical properties, improves ...
Emilia Rodrigues Almeida +4 more
wiley +1 more source
A method for improving the properties of famotidine
Heliyon, 2023 According to crystal engineering, the pharmaceutical intermediate m-nitrobenzoic acid (MNBA), which contains a carboxylic acid group, was selected as a coformer (CCF) for drug cocrystallization with famotidine (FMT), and a new stable FMT salt cocrystal ...
Yongfeng Zhao +6 more
doaj +1 more source
Propellants, Explosives, Pyrotechnics, Volume 51, Issue 7, Page 1044-1057, July 2026.Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source
Molecular Therapy: Nucleic AcidsFollowing the success of COVID-19 vaccines and therapies, mRNA-based therapeutics have attracted significant attention. Codon optimization is crucial for improving translation efficiency and mRNA stability, both of which are necessary for developing ...
Juseong Kim +7 more
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Screening of coformers for quercetin cocrystals through mechanochemical methods
Eclética Química, 2022 Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects.
Fayene Zeferino Ribeiro de Souza +4 more
doaj +1 more source
Systematic coformer contribution to cocrystal stabilization: energy and packing trends
CrystEngComm, 2020 CSD data mining and energy calculations show that coformer self-interactions might significantly contribute to the packing energy stabilization of cocrystals.
Mazzeo P. P. +4 more
openaire +3 more sources
Molecules, 2020 Despite the technological importance of urea perhydrate (percarbamide) and sodium percarbonate, and the growing technological attention to solid forms of peroxide, fewer than 45 peroxosolvates were known by 2000.
Alexander G. Medvedev +4 more
doaj +1 more source