Results 61 to 70 of about 698 (167)

Mechanochemically Driven Synthesis of Anticancer Cocrystals: A Case Study of Lenalidomide

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The combination of crystal engineering and mechanochemical approaches is a powerful strategy for the rational screen and development of new solid forms of active pharmaceutical ingredients (API). New supramolecular patterns formed between an API and a coformer allow the adjustment of physicochemical properties of drugs.
Ana C. S. Carvalho, M. Teresa Duarte, Clara S. B. Gomes, Mafalda Sarraguça, Alessia Bacchi, Michele Prencipe, Job Gieling, Natalia Shemchuk, Daniel M. Baier, Koen Robeyns, Hector Polyzois, Lidia Tajber, Christos M. Chatzigiannis, Evelina Colacino, Tom Leyssens, Vânia André   +15 more
wiley   +1 more source

A Two-Stage Approach to the Study of Potato Disease Severity Classification

Agriculture
Early blight and late blight are two of the most prevalent and severe diseases affecting potato crops. Efficient and accurate grading of their severity is crucial for effective disease management.
Yanlei Xu, Zhiyuan Gao, Jingli Wang, Yang Zhou, Jian Li, Xianzhang Meng   +5 more
doaj   +1 more source

Structural Characterization of Co-Crystals of Chlordiazepoxide with p-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-ray Diffraction, FTIR and Raman Spectroscopy

Pharmaceutics, 2020
The low water solubility of benzodiazepines seriously affects their bioavailability and, in consequence, their biological activity. Since co-crystallization has been found to be a promising way to modify undesirable properties in active pharmaceutical ...
Patrycja Garbacz, Dominik Paukszta, Artur Sikorski, Marek Wesolowski   +3 more
doaj   +1 more source

Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer

Pharmaceutics, 2022
Hesperetin (HES) is a key biological active ingredient in citrus peels, and is one of the natural flavonoids that attract the attention of researchers due to its numerous therapeutic bioactivities that have been identified in vitro.
Yanjie Liu, Fan Yang, Xiuhua Zhao, Siying Wang, Qilei Yang, Xiaoxue Zhang   +5 more
doaj   +1 more source

Solubilities of CL‐20 and MDNT in Organic Solvents for Technical Cocrystallization

Propellants, Explosives, Pyrotechnics, Volume 51, Issue 5, Page 761-768, May 2026.
ABSTRACT The 1:1 molar cocrystal of 2,4,6,8,10,12‐hexanitro‐2,4,6,8,10,12‐hexaazaisowurtzitane (CL‐20) and 1‐methyl‐3,5‐dinitro‐1,2,4‐triazole (MDNT) is reported to show a detonation velocity 100 m/s faster than β‐HMX. To establish a scalable synthesis method, the solubility of ε‐CL‐20 and MDNT was investigated.
Eduard Wegert, Peter Schultz, Thomas M. Klapötke   +2 more
wiley   +1 more source

Charge Transport in Ternary Charge‐Transfer Solid Solution Single Crystals

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
This study deconvolutes the roles of indirect (superexchange) and direct electronic coupling on charge transport in single crystals of an organic charge‐transfer molecular semiconductor (OSC). This model system elegantly demonstrates that structural defects introduced by chemical dopants play a significant role in the electronic performance ...
Jonathan C. Novak, Manikanta Makala, Edith L. MacKenzie, Veaceslav Coropceanu, Kimberly Agosto, Abigail A. Moravek, Oana D. Jurchescu, Ren A. Wiscons   +7 more
wiley   +1 more source

Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Non‐covalent interactions (NCIs) drive the formation of organic cocrystals with diverse structures and tunable optoelectronic properties. This review explores the essential factors governing these properties, highlighting how the sequential nucleation of cocrystals leads to the self‐assembly of organic hierarchical structures (OHSs).
Ya‐Nan Zhu, Jin Feng, Ying‐Xin Ma, Hong‐Tao Lin, Li‐Wei Xie, Qi‐Liang Peng, Xue‐Dong Wang   +6 more
wiley   +1 more source

Crystal structure of 2,3,5,6-tetrakis(pyridin-2-yl)pyrazine hydrogen peroxide 4.75-solvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The structure of the title co-crystal, C24H16N6·4.75H2O2, consists of a 2,3,5,6-tetrakis(pyridin-2-yl)pyrazine coformer and hydrogen peroxide solvent molecules in an overall ratio of 1:4.75.
Mger A. Navasardyan, Stanislav I. Bezzubov, Lyudmila G. Kuz'mina, Petr V. Prikhodchenko, Andrei V. Churakov   +4 more
doaj   +1 more source

Improvement of physicochemical parameters of acyclovir using cocrystallization approach

Brazilian Journal of Pharmaceutical Sciences
Acyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%).
Jignasa Ketan Savjani, Chirag Pathak
doaj   +1 more source

Larvicidal Activity of Naringenin: Betaine Cocrystals Against Aedes Aegypti

Crystal Research and Technology, Volume 61, Issue 2, February 2026.
This study demonstrates that naringenin: betaine cocrystals significantly enhance larvicidal activity against Aedes aegypti compared to physical mixtures or pure compounds. Improved dissolution properties contributed to higher mortality rates, supporting the use of cocrystallization as a promising green technology for vector management.
Felipe Zaniol, Patricia Viera de Oliveira, Daniel Albeny‐Simões, Jacir Dal Magro, José Vladimir de Oliveira   +4 more
wiley   +1 more source