Results 61 to 70 of about 1,272 (143)

FORMULATION AND EVALUATION OF COCRYSTALS OF A BCS CLASS II DRUG USING GLYCINE AS COFORMER

, 2022
Objective: Development of pharmaceutical co-crystals is an interesting area of research as co-crystals are unique because they have the advantages of maintaining drug’s intrinsic properties along with improvement in its physicochemical attributes ...
ANAND, RACHNA, NANDA, ARUN
core  

Crystal structure of 2,3,5,6-tetrakis(pyridin-2-yl)pyrazine hydrogen peroxide 4.75-solvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The structure of the title co-crystal, C24H16N6·4.75H2O2, consists of a 2,3,5,6-tetrakis(pyridin-2-yl)pyrazine coformer and hydrogen peroxide solvent molecules in an overall ratio of 1:4.75.
Mger A. Navasardyan, Stanislav I. Bezzubov, Lyudmila G. Kuz'mina, Petr V. Prikhodchenko, Andrei V. Churakov   +4 more
doaj   +1 more source

On the influence of using a zwitterionic coformer for cocrystallization: Structural focus on naproxen - proline cocrystals

, 2013
Four original cocrystal structures incorporating a zwitterionic amino acid, prolinium, and a therapeutical agent from profen pharmaceutical family, naproxen, are highlighted and characterized in this study.
Wouters, Johan, Tilborg, A., Tilborg, Anaëlle, Norberg, Bernadette, Springuel, Géraldine, Leyssens, Tom, Norberg, B., Wouters, J.; id_orcid, Springuel, G., Leyssens, T.   +9 more
core   +1 more source

An exploration into the amide–pseudo amide hydrogen bonding synthon between a new coformer with two primary amide groups and theophylline

, 2017
Double the FUN! A rare amide–pseudo amide hydrogen bonding synthon has been established for the co-crystal between a new coformer with two primary amide groups and theophylline.
Datta Markad, Sanjay K. Mandal
core   +1 more source

Tracking cocrystallization of active pharmaceutical ingredients with Bbenzoic acid coformer using Broadband Acoustic resonance Dissolution Spectroscopy (BARDS) [PDF]

, 2020
This study investigates the use of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) as a detection method for the formation of cocrystals.
Hanna-Brown, Melissa, Rao Khandavilli, Udaya B. Rao, Krüse, Jacob, Lawrence, Simon E., Kent, Christopher, Alfarsi, Anas, McSweeney, Seán, Fitzpatrick, Dara   +7 more
core   +1 more source

Improvement of physicochemical parameters of acyclovir using cocrystallization approach

Brazilian Journal of Pharmaceutical Sciences
Acyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%).
Jignasa Ketan Savjani, Chirag Pathak
doaj   +1 more source

COFORMER SELECTION: AN IMPORTANT TOOL IN COCRYSTAL FORMATION

, 2014
Cocrystals are multicomponent system in which one component is Active Pharmaceutical Ingredient (API) and another is called coformer. So coformer selection is one of the main challenge in cocrystal development which is compatible with API.
Fukte, Sulbha R., Wagh, Milind P., Rawat, Shilpi   +2 more
core  

A New Multi-Component Solid of Atorvastatin Calcium with a Dipicolinic Acid Coformer for Improving the Water Solubility

, 2023
Atorvastatin calcium is a potent active pharmaceutical ingredient that reduces blood cholesterol levels. However, oral bioavailability is low because it is difficult to dissolve in water. Therefore, further research to increase the solubility of the
Ari Satia Nugraha, Yudi Wicaksono, Eka Deddy Irawan, Sofyan Dimas Nurhansyah, Nadifa Nada   +4 more
core   +1 more source

Synthesis of Two Novel Azilsartan Cocrystals: Preparation, Physicochemical Characterization and Solubility Studies

Crystals, 2020
Azilsartan is a novel angiotension II receptor blocker primarily used to treat high blood pressure. This is not a formulation-friendly molecule largely due to the inherent water-solubility pitfalls.
Lei Gao, Xian-Rui Zhang
doaj   +1 more source

Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim

, 2022
[Image: see text] The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine ...
O’Malley, Ciaran, Andrea Erxleben (1519126), Ciaran O'Malley (12628654), Lamis Alaa Eldin Refat (12379093), Patrick McArdle (1457956), John M. Simmie (1503457), Alaa Eldin Refat, Lamis, Erxleben, Andrea, Simmie, John M., McArdle, Patrick   +9 more
core   +1 more source